One option is an MEK inhibitor, which inhibits the mitogen - activated
protein kinase enzymes used to therapeutically affect the MAPK pathway that is often overactive in cancers.
Not exact matches
New research from the University of Copenhagen's Department of Nutrition, Exercise and Sports reports that the
enzyme AMP - activated
protein kinase (AMPK) plays a crucial role in enhancing the ability of insulin to stimulate glucose uptake in muscles.
The
protein, known as focal adhesion
kinase, or FAK, activates an
enzyme called AKT, which helps islet cells in the pancreas to survive.
Cunningham and her postdoc at the time, Christine Kirvan, found that the antibodies literally bind to human neurons, activating an
enzyme called calcium / calmodulin - dependent
protein (CaM)
kinase II.
This gene is one of many known to be involved in the formation of emotional memories, and encodes an
enzyme called
protein kinase C -.
Now, researchers at University of California San Diego School of Medicine and Harvard Medical School have found that the
enzyme Protein Kinase C (PKC) alpha is necessary for amyloid beta to damage neuronal connections.
One reason may be that DDRs are
protein enzymes known as tyrosine
kinases that act as on and off switches of the cell self - cleaning process known as autophagy.
This particular liver cancer arises from a mutation that produces an abnormal form of the
enzyme that is the topic of this current work,
protein kinase A, and alters the
enzyme's role in cell signaling.
When calcium floods a neuron as a memory is formed, it turns on an
enzyme called CaMKII (calcium / calmodulin - dependent
protein kinase).
«A number of other types of tumors have been shown to be driven by chimeras, but this one is unique — it codes for a
kinase, an
enzyme that modifies other
proteins, that has not been identified in cancers.»
Transmission of signals in a cell is controlled by the coordinated activity of two families of
enzymes:
protein tyrosine
kinases, which add a phosphate group to
proteins, and
protein tyrosine phosphatases, which remove them.
Regorafenib is one of a new generation of anti-cancer therapies that attack tyrosine
kinases —
enzymes that activate other
proteins.
Furthermore, the research revealed the part of the EMSY
protein is changed by an
enzyme called
protein kinase A.
These phosphate groups are attached to
proteins by
enzymes known as
kinases, while phosphatases act as their counterparts by removing them.
«We know dysregulation of a
protein enzyme called multifunctional CaM
kinase II plays a role in disrupting sodium channel function in cardiac disease, but it was a matter of determining how this occurred and whether we could we prevent it for therapeutic benefit,» said Hund, an associate professor of biomedical engineering at The Ohio State University.
As the name suggests,
kinase inhibitors interrupt the function of
kinases — a particular type of
enzyme — and effectively shut down the activity of
proteins that contribute to cancer.
Focusing on a particular group of
enzyme - blocking compounds called
protein kinase inhibitors, they identified 31 compounds that inhibit malaria growth without harming the host.
They gave mice a drug — AICAR, which has been used in clinical trials for various diseases — that upped AMP - activated
protein kinase (AMPK), an
enzyme that becomes activated during a workout.
Duke University assistant professor Emily Derbyshire and colleagues identified more than 30
enzyme - blocking molecules, called
protein kinase inhibitors, that curb malaria before symptoms start.
They found that an
enzyme called DNA - dependent
protein kinase, or DNA - PK, increases in activity with age.
The
enzymes that phosphorylate
proteins are called
kinases, and many new cancer drugs are
kinase inhibitors.
For the new study, the research team focused on activating an
enzyme known as AMP - activated
protein kinase, or AMPK, which — among other roles — stimulates the breakdown of glucose for energy.
The study, published in Nature Communications today, focused on
protein kinases,
enzymes that are key regulators of cellular processes.
As part of their study, Zylka and Yi found that
protein kinase A (PKA) is the
enzyme that tacks the phosphate group onto UBE3A.
In their previous study, the researchers found that drugs that inhibit FGFR3
kinase, an
enzyme that helps the
protein produced by this fusion gene do its work, increased survival when tested in mice with glioblastoma.
AMPK (adenosine monophosphate - activated
protein kinase) is an
enzyme that acts as a metabolic master switch and is activated in response to low cellular energy levels.
Proper transfer of V1 complexes or subunits from the membrane to the cytoplasm and back appears to require not only phosphorylation events, conformational changes in the V1VO holoenzyme, the V1 complex and the V1 subunit C, but also the temporary interaction with
protein kinase A, cytoskeletal elements, the heterotrimeric
protein complex RAVE and the glycolytic
enzyme aldolase.
In another experiment, mice with this form of glioblastoma were given a drug that inhibits FGFR
kinase, an
enzyme essential for the
protein produced by FGRF - TACC to do its work.
In an alternative scenario the same
enzymes —
kinases that attach phosphate groups to
proteins — modify the negative regulators, accelerating their degradation and freeing p53 of their antagonists.
Abbreviations: AGL = glycogen debranching
enzyme; GSK3A / B = glycogen synthase
kinase 3 α / β; GYS2 = glycogen synthase 2; PYGL = glycogen phosphorylase, liver form; PCK1 / 2 = phosphoenolpyruvate carboxykinase 1/2; FBP1 / 2 = fructose -1,6-bisphosphatase 1/2; G6PC = glucose -6-phosphatase; G6PD = glucose -6-phosphate 1 - dehydrogenase; GLUT - 2 = glucose transporter 2; INSR = insulin receptor; IRS1 / 2 = insulin receptor substrate 1/2; PIK3CA / B / D = PI3 -
kinase subunit α / β / δ; and AKT1 =
protein kinase B - α.
The gene produces an
enzyme (diacylglycerol
kinase eta) that functions at a point closer to the root of the lithium - sensitive pathway than does the
protein that lithium is thought to target.
Tyrosine is an amino acid present in
proteins that contains a hydroxyl moiety, and
kinases are
enzymes that catalyze phosphorylation (addition of a phosphate group) of various substrates in the cell.
Researchers have developed a new structural understanding of how the two key subunits of one of the cell's most important
enzymes —
protein kinase A — work together.
Molecular cloning has demonstrated that dunce codes for the
enzyme, cAMP phosphodiesterase; rutabaga codes for adenylyl cyclase; DCO codes for the catalytic subunit of
protein kinase A, and CREB a transcription factor that is phosphorylated and activated by
protein kinase A.
9/20/2007 UCSD Study Reveals the Regulatory Mechanism of Key
Enzyme Protein kinase A (PKA) involved in cardiac disease and breast cancer Research conducted at the University of California, San Diego (UCSD) School of Medicine has shed new light on the structure and function of one of the key
proteins in all mammalia... More...
In addition, caffeine may increase the activity of several signaling
enzymes, including the calcium - dependent
protein kinase and
protein kinase B (also called Akt), which have roles in muscle glucose uptake during and after exercise.
Kinases are
enzymes that use chemicals called phosphate groups to regulate other
proteins.
The Lexicon efforts are focused on gene families that are pharmaceutically important, such as transporters, G -
protein coupled receptors (GPCRs), ion channels,
kinases and other key
enzymes, membrane
proteins (e.g., receptors), and secreted
proteins.
The first task was to identify several specific amino acid sites in the region FUS uses to bind with other
proteins where the natural
enzyme DNA - dependent
protein kinase (DNA - PK) causes phosphorylation.
Kinases are important
enzymes that activate other
proteins by adding a phosphate group to them.
In the study, functional Ikaros
protein produced from the one remaining normal Ikaros gene was restored with a novel class of drugs that target a specific
enzyme called casein
kinase 2 or CK2.
104 Several hormetic response pathways have been identified involving
enzymes (
kinases and deacetylases including Sirtuins), transcription factor - regulation the expression of several major categories of
proteins including chaperones, antioxidant
enzymes and growth factors.
In several clinical trials, berberine effectively stabilized blood sugar by activating a regluatory
enzyme known as adenosine monophosphate - activated
protein kinase, or AMPK.
This
protein synthesis relies on all sorts of
enzymes to work, from helicases that open up the DNA strand to be read, to RNA polymerases that create RNA - based on the original DNA sequence, to
protein kinases.
ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for
proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase
enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band cell — type of white blood cell Baso basophil — type of white blood cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho]
kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil — type of white blood cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by
protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood cells Hb, Hgb hemoglobin — iron rich protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppr
protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood cells Hb, Hgb hemoglobin — iron rich
protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppr
protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase
enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total
protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppr
protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine
Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppr
Protein - Crea Ratio urine
protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppr
protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppression)
• S. Dey, Development of
Enzyme - Based Screening Methodology for Combinatorial catalysis — Identification of Novel Chiral Salens for the Hydrolytic Kinetic Resolution of Epoxides, Dissertation, 2007, University of Nebraska • B. J. Morgan, S. Dey, S. W. Johnson, and M. C. Kozlowski, Design, Synthesis and Investigation of
Protein Kinase C Inhibitors: Total Syntheses of (+)- Calphostin D, (+)- Phleichrome, Cercosporin and Novel Perylenequinones, J. Am.