Sentences with phrase «protein on the cancer cell»

Erbitux binds to and inhibits a growth - promoting protein on cancer cells.

Triple negative breast cancers are those that do not have estrogen or progesterone receptors, and do not have an excess of the HER2 protein on the cancer cell surfaces.

They are equipped with special receptors called chimeric antigen receptors (CARs) that recognize specific proteins on cancer cells and eliminate those cells.

Not exact matches

The treatment is a type of so - called CAR T - cell therapy — taking a patient's own immune cells, called T cells, genetically manipulating them to attack specific proteins on cancer, and infusing them back into the patient.

The findings, published in Proceedings of the National Academy of Sciences (PNAS), define a mechanism in which the oncogenes turn on a protein called RSK2 that is required for cancer cells to move.

One way cancer cells do this is by expressing a protein ligand that binds to a receptor on the T cells to prevent the T cell from recognizing and attacking the cancer cell.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

The scientists hope their findings on cell migration in zebrafish will open up new perspectives for research on proteins that control metastasis and thus the malignancy of cancer.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

PARP inhibitors target and block proteins which cancer cells depend on to repair DNA for their survival.

Instead of displaying the full complement of incriminating proteins on the tumor cell's surface, the dog cancer displays just a few, obfuscating the invasion underway.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

«We also know that this RhoB pathway, once turned on, can stimulate the expression of two proteins: p21, which prevents cells from replicating, and BIM, which induces cell death — both of which can help stop cancer growth.»

Moderna is also doing animal safety tests of a personalized cancer vaccine that would code for immune - activating proteins unique to a person's cancer cells, based on genetic sequencing of their tumor.

But when PD - 1 binds to proteins called PD - L1 and PD - L2 on the surface of certain cancer cells, the T cells essentially become paralyzed: the immune attack on cancer is called off.

siRNAs are very small molecules that carry genetic information to cells, but unlike DNA that can turn genes on, siRNA interferes with the production of particular proteins and can turn cancer genes off.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

In kidney cancer, the over-expressed NPTX2 protein is secreted from the cell and then attaches itself to GluR4 on the kidney cancer cell membrane.

Regulating and removing proteins is vital for all cells, but cancer cells are highly dependent on their protein production machinery to fuel their proliferation.

Building on this concept, Sushant Patkar of the University of Maryland and colleagues hypothesized that alterations in protein interaction networks in breast cancer cells may change the function of individual genes.

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

The team is also planning further research to find out more about why pancreatic cancer cells rely on PAK4 and what other proteins and pathways PAK4 is interacting with to drive cell growth and migration.

Triple - negative breast cancers are those whose cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces.

Further research could test these cancer stem cell gene expression at the RNA and protein level in circulating tumor cells and biopsies from patients on trial.

When the team turned the gene on in a set of colon cancer cells and injected them into mouse spleens, the cells spread into the animals» livers; cells that didn't make the L1CAM protein stayed put.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

In the new study, Burrows and colleagues focused on the protein HIC1, or «Hypermethylated in cancer 1, «so named because it was first identified in cancer cells; however, it also helps regulate gene expression in normal cells.

In an effort to unravel that mystery, Rodriguez and his colleagues focused on the ways those cancer cells regulate the expression of genes or whether they make their constituent proteins.

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

«When a cancer cell comes into contact with it, a protein on the cell's surface, known as APP, activates DR6.

To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.

The disabled gene codes for the protein PD - 1, which normally puts the brakes on a cell's immune response: cancers take advantage of that function to proliferate.

The researchers performed lab experiments on cells derived from a cervical cancer and found that when DOHH is blocked, a protein known as eIF5A fails to mature.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

One of the immunotherapeutic approaches that has been explored thus far relies on the use of monoclonal antibodies that specifically target a protein present on the surface of prostate cancer cells called prostate specific membrane antigen (PSMA) to elicit an anti-tumor immune response and control the cancer.

They work by sticking to specific proteins found on the surface of cancer cells, flagging them up to be killed by the immune system.

In earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer cases.

The cancer cell marker that Johnson and her team identified was a specific change in protein glycosylation, that is, a unique pattern of sugars decorating a protein found on the cell surface.

Blocking a protein found on the surface of ovarian cancer cells could prevent or reduce the spread of the disease to other organs, according to new research at the University of Illinois at Chicago.

Working in mouse models of breast cancer and breast tumor samples from patients, Longmore and his colleagues showed that a protein that sits on the surface of tumor cells, called DDR2, binds to collagen and activates a multistep pathway that encourages tumor cells to spread.

First, the P - Selectin proteins on the platelet membrane bind to the CD44 proteins on the surface of the cancer cell, locking it into place.

By engineering red blood cells to have «sticky» proteins on their surface, a team of researchers has given the cells the ability to carry anything from drugs to treat immune disorders or cancer to radioactive molecules used in imaging of blood vessels.

The sulforaphane induced both types of cells to increase their levels of a protein that turns on genes that promote detoxification of carcinogens, like those found in cigarettes, and protect cells from cancer.

The nanoparticle has interleukin 2 on its surface, so when the protein is around it acts as a switch, a contact with the cancer cell to bind to the receptor and to carry out its biological action.

These carry some of the same proteins on their surface as many cancer cells, says Wu.

A report in the 15 February issue of the Proceedings of the National Academy of Sciences suggests that a lotion containing an algal protein can ward off sunburns — often the first step on the road to skin cancer — by repairing part of the damage to skin cells» chromosomes.

Cancers would be caught at their earliest stage and other stages of development, and doctors would have the necessary protein or genetic information from these captured cells to customize your treatment based on the specific markers for your cancer.

While this current study primarily focused on the role of Myc and TXNIP in triple negative cancer nutrient uptake and utilization, Ayer said the proteins also appear to play a role in metastasis, the process by which cancer cells spread to other parts of the body.

Both genes code for proteins that function as growth factor receptors, meaning they sit on the surface of cells and, when activated, can spur the rapid cell growth that is a hallmark of cancer.