Sentences with phrase «protein phosphorylation»

Justin Drake, a postdoctoral researcher in Witte's lab at UCLA (now an assistant professor at Rutgers Cancer Institute of New Jersey), led the phosphoproteomics work, producing a new encyclopedia of protein phosphorylation in prostate cancer cells and tissues.

The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.

The types of stimuli that share this common effect on protein phosphorylation include numerous substances that do not act through cyclic AMP.

In the past 27 years, we have found that this cycling sugar modification of proteins — called O - linked N - acetylglucosamine, or O - GlcNAc — is nearly as common as protein phosphorylation and often competes with it at the same or proximal sites on proteins to regulate nearly every cellular process in response to nutrients and stress.

Because a majority of tumors exhibit phosphorylation changes at some point in their development, his lab looked specifically at protein phosphorylation in vesicles.

«Nearly 60 years of protein phosphorylation research has uncovered many important functions for phosphorylation of proteins inside the cell, so there's no reason to believe these mechanisms will be any different for phosphorylation of proteins outside the cell,» said Sandra Wiley, PhD, staff research associate in Dixon's lab and co-first author of the study.

The presence of a great variety of neuron - specific phosphoproteins in nervous tissue supports the view that protein phosphorylation plays many roles in neuronal function.

Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases

Initial empirical testing for c - ABL was carried out via an in vitro kinase approach with purified recombinant kinases at the MRC Protein Phosphorylation and Ubiquitination Unit in Dundee, Scotland.

Acting via the MyD88 adaptor and STAT1 protein phosphorylation, activated TLR4 results in nuclear translocation of the transcription factor NF - κB and subsequent mRNA expression of proinflammatory cytokines.

Identified and analyzed plant protein phosphorylation events and their role in regulating cellulose biosynthesis.

These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis.

This includes determining the exact signaling mechanisms (protein phosphorylation events) of regulation.

His discovery of protein phosphorylation as a regulatory mechanism (with Edmond Fischer) touched all aspects of biomedical science and profoundly influenced therapeutic approaches now widely used in clinical care.

The data included protein expression, protein phosphorylation, which indicates which signaling pathways are activated, and messenger RNA and microRNA expression.

«This study is a continuum of our almost a decade long efforts to systematically dissect the molecular mechanisms behind the protein phosphorylation.

The regulatory system to control redox balance involves sugar - dependent gene regulation and protein phosphorylation.

Our new study uses transcriptomics of cell fragments of the ciliate Stentor to reveal the importance of protein phosphorylation, microtubule - based processes and genes involved in the cell cycle for cellular regeneration.