Next up: a larger trial in hundreds of patients to see if lowering mutant Htt
protein slows progression of the disease, then a trial in healthy people who carry the mutant HTT gene to see if antisense treatments could prevent Huntington's altogether.
Not exact matches
Still, researchers are intrigued by the possibility that cells may use these clearance mechanisms to propagate misfolded
proteins throughout the brain — in which case targeting the mechanisms could conceivably
slow disease
progression.
«We do not yet have treatments that can
slow the
progression of Huntington's disease but, when we do, measuring the mutant
protein in CSF could guide clinical decisions such as the best time to start a treatment,» said Dr Douglas Macdonald at CHDI.
The research also indicates that a low
protein, low salt diet may not only
slows the
progression of CKD as an effective adjunct therapy, but it can also be used for the management of uremia, or high levels of urea and other uremic toxins in the blood, in late - stage or advanced CKD and help patients defer the need to initiate dialysis.
However, Dr. Kissler's group discovered that reducing levels of the RGS1
protein did not
slow the
progression of the disease in mouse models, suggesting that it may not offer much potential for human treatment.
«Our results indicate that exercise may
slow the
progression of Parkinson's disease by turning on the protective gene DJ - 1 and thereby preventing abnormal
protein accumulation in brain,» Freed said.
Emphasising their desire to move the drug forward, in a separate announcement made directly to the HD community, Ionis said «Upon study completion, the next step for this program will be to conduct a study to investigate if decreasing mutant huntingtin
protein with IONIS - HTTRx can
slow the
progression of this terrible disease.»
Decreasing the amount of mutant TTR
protein should
slow the
progression of the disease, and decreasing specific
protein levels is what RNAi does for you, as it goes after the relevant messenger RNA.
A
protein in the brain may hold a key to
slowing progression of Alzheimer's disease, a new study suggests.
Direct replacement of the AAT
protein into the blood may be used to
slow the
progression of lung disease.
Reducing the ratio of animal to plant
protein in men's diets may
slow the
progression of prostate cancer.
Studies have found that increasing
protein intake
slows the
progression of sarcopenia and may even reverse it by enhancing muscle
protein anabolism
Patients with high urine
protein loss may also benefi t from the use of angiotensin converting enzyme (ACE) inhibitors drugs, which will help to
slow the
progression of disease.
Restriction of dietary
protein has been demonstrated to
slow the rate of
progression of renal damage.
Research used to indicate low
protein diets
slowed the
progression of renal failure, but that isn't the case anymore.
Low - phosphorous foods are much more effective than low -
protein foods in
slowing down the
progression of renal disease.
Early detection of this
protein allows your holistic veterinarian to help
slow the
progression of the disease.
-
Slows down gastric emptying which assists with the proper digestion of
proteins - Combats diarrhea by regulating the
progression of chyme in the small intestine and fecal matter in the colon.