Sentences with phrase «protein syntaxin»

During synaptic vesicle fusion, the soluble N - ethylmaleimide - sensitive factor — attachment protein receptor (SNARE) protein syntaxin - 1 exhibits two conformations that both bind to Munc18 - 1: a «closed» conformation outside the SNARE complex and an «open» conformation in the SNARE complex.

Not exact matches

Before the fusion of synaptic vesicles with the plasma membrane, a protein complex is thought to form between VAMP — an integral membrane protein of the vesicle — and two proteins associated with the plasma membrane, SNAP - 25 and syntaxin.

Scheller established that synaptotagmin clutches a brain protein that he named syntaxin.

Because the two molecules bound to one another Scheller proposed that VAMP, the synaptic vesicle protein, bridges to syntaxin, the plasma membrane protein — thereby providing a scaffold onto which the molecular machinery that catalyzes membrane fusion can be assembled.

Südhof had discovered a protein, complexin, that strongly adheres to the VAMP / synaptobrevin, syntaxin, and SNAP - 25 bundle.

In particular, he characterized the first synaptic vesicle membrane associated protein, v - SNARE or VAMP, and the first plasma membrane associated target proteins, t - SNAREs or syntaxin and SNAP - 25.

Remarkably he found that these proteins, when exposed to brain extracts, formed a complex with the vesicle protein VAMP and two plasma membrane proteins, syntaxin and SNAP - 25, precisely the proteins that Scheller had identified earlier.

Rothman also proposed that SNAP - 25, VAMP / synaptobrevin and syntaxin represent members of a large family of proteins, different forms of which are involved in membrane fusion in all cells, and in different compartments within cells.

Only three proteins stuck: VAMP / synaptobrevin, syntaxin and a third called SNAP - 25 (which dwells mainly in the plasma membrane).

Scheller, Südhof and other investigators also demonstrated that the bacterial poisons tetanus toxin and botulinum toxin block neurotransmitter release, by cleaving apart the vesicle and membrane associated proteins synaptobrevin, SNAP - 25 and syntaxin.

[14] ARA also activates syntaxin - 3 (STX - 3), a protein involved in the growth and repair of neurons.