Sentences with phrase «protein trafficking between»
Wild - type huntingtin participates in protein trafficking between the Golgi and the extracellular space.
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Previous research conducted at Mount Sinai found that the trafficking of protein molecules between the nucleus (the cellular compartment containing the genetic information of the cell) and the cytoplasm is altered in neurodegenerative disease.
Pores, composed of many different proteins, the nucleoporins, cross the nuclear envelope and monitor the heavy traffic of the molecules, which takes place between the nucleus and the cytoplasm of the cell.
The trafficking of proteins between the ER and Golgi must be tightly modulated to maintain the health of the cell and prevent diseases like cancer from taking hold.
In a general sense, FP timers can be used in any situation where one wants to understand the relationship between the age of a cell, protein, or cellular structure and a particular biological event (trafficking to a subcellular location, start of gene expression, development of a cell structure, etc).
The Johannes group has made two major contributions in this context: the discovery of a membrane trafficking interface between early endosomes and the Golgi apparatus, and the demonstration that dynamic protein - induced glycosphingolipid reorganization acts as a driving force for membrane invagination in clathrin - independent endocytosis.
Distinguish between models for trafficking to the lysosome by fusing Medium - FT to LAMP - 2A, a lysosome - associated membrane protein, and following its subcellular localization overtime (Subach et al..)