Sentences with phrase «protein trafficking in»

His graduate work focused on the molecular mechanisms of DNA replication and protein trafficking in mitochondria, and the translational control of novel mitochondrial protein isoforms.

Pathways and mechanisms of protein trafficking in polarized epithelia; Wilson and Menkes Diseases; copper ATPases

Selective imaging by correlated optical and electron microscopy of protein molecules of known ages will clarify fundamental processes of protein trafficking in situ.

Not exact matches

The meal options I came up with had to be: # 1 things that would be fairly easy to prepare (I wasn't about to take an extra hour on Sunday to make something elaborate), # 2 had to be foods I could easily manipulate the nutritional profile for (ensuring a balance of protein, carbs, and fat), # 3 the food had to store well in the fridge or freezer, # 4 they had to reheat well in either the toaster or microwave OR be eaten cold right from the fridge, and # 5 ideally, they needed to be things she could easily eat in the car on the way to school (remember, it takes us at least 20 minutes with no traffic to get to school so eating in the car gives us even MORE time to sleep lol).

There is significant opportunity in improving protein quality on - premise in terms of increasing traffic, brand equity, purchase intent and willingness to pay more per item, as well as reversing restaurant avoidance due to negative protein quality perceptions

The observation that loss - of - function mutations in DENND5A causes epileptic encephalopathy suggests that DENND5A protein controls membrane trafficking pathways critical for normal neuronal development and strengthens the argument that protein trafficking processes in cells are critical for normal neuronal development and function.

Other genes activated by the guide RNA encode mitochondrial proteins that help cells regulate their energy metabolism, and trafficking proteins that are involved in packaging and transporting other proteins.

The huntingtin gene encodes a large scaffold protein, with many interaction partners, which is thought to be involved in intracellular trafficking.

Previous research conducted at Mount Sinai found that the trafficking of protein molecules between the nucleus (the cellular compartment containing the genetic information of the cell) and the cytoplasm is altered in neurodegenerative disease.

The new study revealed the Ebola VP40 protein assumes different structures to perform multiple roles in the virus's life cycle — membrane trafficking, virus assembly and control of replication.

He hopes to pursue projects such as developing therapeutics with chemists, working with biophysicists to study protein conformational changes relevant to viral entry into the cell, and investigating cellular trafficking pathways relevant to the viral life cycle in collaboration with cell biologists.

A protein that transports the simple chemical choline plays a major role in vesicle trafficking, ion homeostasis, and growth and development in plants, according to two new studies publishing 28 December in the open - access journal PLOS Biology, by Dai - Yin Chao of the Shanghai Institutes for Biological Sciences, China, and Sheng Luan of the University of California, Berkeley, USA, and co-workers.

CTL1 is also found in animal cells, Chao noted, and thus the study concluded that «characterizing CTL1 as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but vesicle trafficking in general.»

It was first described by Francis Crick in 1956 as one - way traffic: as: «DNA makes RNA and RNA makes protein.»

Additionally, Bardet - Biedl syndrome is a metabolic disease in which trafficking of proteins within the cilium is blocked.

That might seem like a run - of - the - mill molecular traffic violation, but it results in an entirely different protein than the one encoded by DNA — a clear violation of the central dogma.

Then, the research group examined the molecular mechanism behind the impaired synaptic functions and behaviors in ARHGAP33 KO mice and found that ARHGAP33 is localized to the Golgi apparatus to regulate intracellular protein trafficking of the Tropomyosin receptor kinase B (TrkB) receptor, a neurotrophin receptor, to synaptic sites.

In a paper published in the Journal of Neuroscience, the OIST Cell Signal Unit, led by Professor Tadashi Yamamoto, reported that mice lacking an intracellular trafficking protein called LMTK3, are hyperactivIn a paper published in the Journal of Neuroscience, the OIST Cell Signal Unit, led by Professor Tadashi Yamamoto, reported that mice lacking an intracellular trafficking protein called LMTK3, are hyperactivin the Journal of Neuroscience, the OIST Cell Signal Unit, led by Professor Tadashi Yamamoto, reported that mice lacking an intracellular trafficking protein called LMTK3, are hyperactive.

The proteins pile up, and these traffic jams produce the swellings in the axons that Smith sees in his experiments.

They also provide new information on the biogenesis and trafficking of membrane transport proteins, which in time may improve the industrial productivity of yeast.

By addressing CaaX processing of Chs4 we try to increase our current understanding on maturation and trafficking of proteins involved in chitin biosynthesis, but also aim to shed light on the still enigmatic biological function of the post-prenylation steps of CaaX processing.

In the last few years, our group has shown that the ZAP70 kinase and its substrate LAT control the polarization of T cells toward the APC and that LAT trafficking to the IS depends on the SNARE protein VAMP7.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

Biallelic mutation of UNC50, encoding a protein involved in AChR trafficking, is responsible for arthrogryposis.

In Chlamydomonas, we can initiate cilia formation experimentally, which allows us to see cilia during construction and analyze protein traffic while they are made.»

«Lila is a rigorous biophysical chemist, but unlike most chemists who avoid complexity and prefer reductionist type studies, Lila's whole career has been focused on applying chemistry and biophysical methods to the study of peptides and their role in biology as well as protein folding and trafficking in vivo,» says Jeffrey W. Kelly at The Scripps Research Institute.

Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif.

Anterograde trafficking of G protein - coupled receptors: function of the C - terminal F (X) 6LL motif in export from the endoplasmic reticulum.

Transmembrane protein OSTA - 1 shapes sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans.

She moved to the USA and continued to work as a postdoctoral researcher at NICHD / NIH in the laboratory of Dr. Juan S. Bonifacino, where she addressed retrograde trafficking of transmembrane cargoes by retromer protein complexes.

A number of downregulated pathways in the regular meditator group versus the other groups defined the meditation effect, including regulation of protein synthesis and trafficking, viral expression and viral infectious cycle.

G Protein - Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo

Enabled by the chemistry provided by Nate Jui in the Buchwald lab at MIT, Tardiff found that the compound was working by restoring functions mediated by a cellular protein critical for trafficking that was previously thought to be «undruggable.»

To study the effects of LRO - related gene mutations, Dr. Huizing is performing fluorescent protein expression studies using patients» cells in order to examine defective intracellular trafficking.

Raised on the knee of science — her father taught her and her two brothers from a young age about geology, physics, and natural history — Alice Ting now stands firmly on her own two feet among the faculty at MIT's Chemistry Department, where her objective is to «simultaneously harness the power of genetics and the power of chemistry» using new technologies developed in her lab for imaging protein trafficking, protein - protein interactions, and enzymatic activity.

Homer 1, an actin binding protein that is induced by BDNF [72], belongs to a family of scaffolding proteins that localize at the postsynaptic density (PSD)[73, 74] and is believed to play a critical role in signal transduction, synaptogenesis and receptor trafficking at synapses [75].

In this course, trainees will perform experiments involving both classical physiological models, as well as modern reductionist approaches and confocal microscopy to follow trafficking of transporter proteins in cultured cellIn this course, trainees will perform experiments involving both classical physiological models, as well as modern reductionist approaches and confocal microscopy to follow trafficking of transporter proteins in cultured cellin cultured cells.

Once at Yale, Reinisch began to investigate the protein complexes involved in various aspects of membrane trafficking.

In 2014, Anna earned her Ph.D. in Cell & Molecular Biology at Drexel University where she focused on characterizing Sonic Hedgehog signaling pathway and its role in Amyloid Precursor Protein (APP) processing, Amyloid - beta clearance, and trafficking to primary ciliIn 2014, Anna earned her Ph.D. in Cell & Molecular Biology at Drexel University where she focused on characterizing Sonic Hedgehog signaling pathway and its role in Amyloid Precursor Protein (APP) processing, Amyloid - beta clearance, and trafficking to primary ciliin Cell & Molecular Biology at Drexel University where she focused on characterizing Sonic Hedgehog signaling pathway and its role in Amyloid Precursor Protein (APP) processing, Amyloid - beta clearance, and trafficking to primary ciliin Amyloid Precursor Protein (APP) processing, Amyloid - beta clearance, and trafficking to primary cilia.

Vesicle Traffic Late in the Secretory Pathway Little is known about the mechanism of sorting and packaging of secretory proteins that transit from the Golgi complex to the cell surface.

To determine whether huntingtin is involved in trafficking a specific subset of proteins, we measured changes in global transcription levels in embryonic stem cells and neurons lacking huntingtin.

Others including Randy Schekman had discovered NSF to be important for vesicle trafficking and secretion in yeast, leading Rothman to argue that these proteins are involved in vesicle fusion in every cell of the animal kingdom — a universal mechanism for secretion.

Together, these findings support a role for huntingtin in the intracellular trafficking of proteins required for the construction of the extracellular matrix.

The gene is also involved in protein trafficking — the routing of proteins to their proper destination within cells.

Wild - type huntingtin participates in protein trafficking between the Golgi and the extracellular space.

Fragile X mental retardation protein (FMRP), linked to the most common inherited form of mental retardation, appears to orchestrate RNA traffic in neurons.

Identify genes and gene products involved in trafficking of proteins to the lysosome of Baker's yeast; study their conservation in humans and their connection to human diseases such as Alzheimer's and cancer.

In a general sense, FP timers can be used in any situation where one wants to understand the relationship between the age of a cell, protein, or cellular structure and a particular biological event (trafficking to a subcellular location, start of gene expression, development of a cell structure, etcIn a general sense, FP timers can be used in any situation where one wants to understand the relationship between the age of a cell, protein, or cellular structure and a particular biological event (trafficking to a subcellular location, start of gene expression, development of a cell structure, etcin any situation where one wants to understand the relationship between the age of a cell, protein, or cellular structure and a particular biological event (trafficking to a subcellular location, start of gene expression, development of a cell structure, etc).

The Johannes group has made two major contributions in this context: the discovery of a membrane trafficking interface between early endosomes and the Golgi apparatus, and the demonstration that dynamic protein - induced glycosphingolipid reorganization acts as a driving force for membrane invagination in clathrin - independent endocytosis.