Suga, H., Katoh, K. & Miyata, T. Sponge homologs of
vertebrate protein tyrosine kinases and frequent domain shufflings in the early evolution of animals before the parazoan - eumetazoan split.
Dissecting specificity in the Janus kinases: the structures of JAK - specific inhibitors complexed to the JAK1 and
JAK2 protein tyrosine kinase domains
However, like most RIPK2 inhibitors, at 100 nM, > 80 % inhibition of 10 - FYN proto - ocogene, transforming growth factor 2 beta, activin receptor like kinase 2, and lymphocyte
specific protein tyrosine kinase and Lck was also observed.
Transmission of signals in a cell is controlled by the coordinated activity of two families of enzymes:
protein tyrosine kinases, which add a phosphate group to proteins, and protein tyrosine phosphatases, which remove them.
A team of scientists at the National Human Genome Research Institute (NHGRI) sequenced
the protein tyrosine kinase (PTK) gene family in tumor and blood samples from people with metastatic melanoma.