Sentences with phrase «protein tyrosine phosphatase»

In particular, they looked at the possible involvement in the HER2 pathway of a class of enzymes called protein tyrosine phosphatases, or PTPs.

The drug works by inhibiting an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which seems to contribute to cells losing their sensitivity to insulin.

When postdoctoral researcher and first author, Karen M. Doody, Ph.D., screened samples from rheumatoid arthritis patients for the expression of phosphatases, she discovered that an enzyme known as RPTPσ, short for receptor protein tyrosine phosphatase sigma, is highly expressed on the surface of FLS.

Research Focus: My research projects are focused on the roles of protein tyrosine phosphatases (PTPs) in diabetes and rheumatoid arthritis.

Researchers have demonstrated that the enzymatic activity of R5 receptor - type protein tyrosine phosphatases is a requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells and could be a promising drug target for treatment.

Conjugated linoleic acid (CLA) up - regulates the estrogen - regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells.

A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2).

The team, led by molecular biologist Brian Kennedy of the Merck Frosst Center for Therapeutic Research in Pointe Claire - Dorval, Quebec, and biochemist Michel Tremblay of McGill University in Montreal, created a line of mice lacking an enzyme called protein tyrosine phosphatase - 1B (PTP - 1B).

Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with HEPES

It is an enzyme — one in a «superfamily» of 105 called protein tyrosine phosphatases (PTPs)-- that perform the essential biochemical task of removing phosphate groups from amino acids called tyrosines in other proteins.

Transmission of signals in a cell is controlled by the coordinated activity of two families of enzymes: protein tyrosine kinases, which add a phosphate group to proteins, and protein tyrosine phosphatases, which remove them.

Previous studies suggested their movements are blocked when the protein tyrosine phosphatase sigma (PTP sigma), an enzyme found in axons, interacts with chondroitin sulfate proteoglycans, a class of sugary proteins that fill the scars.

I am fortunate to investigate a field of enzymes (protein tyrosine phosphatases) that will celebrate its 30th anniversary this year.

Now, there are a number of phosphatases called PTPs, Protein Tyrosine Phosphatase.

The low - molecular - weight protein tyrosine phosphatase (LMP...

Fousteri G, Stamatis - Nick C. Liossis, Battaglia M. Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity.

Published in Molecular Psychiatry, the manuscript describes the identification and validation of a genetic variant within the protein tyrosine phosphatase receptor - type delta (PTPRD) gene.

Foundation funding has had a great impact on Tonks» research, which has been largely focused on the protein tyrosine phosphatase (PTP) family of enzymes.

Protein tyrosine phosphatase — which plays a role in insulin signaling — has led researchers to conclude that the herbs could be useful in preventing and treating diabetes.

Zinc is involved in insulin signaling by inhibiting the enzyme protein tyrosine phosphatase to increase phosphorylation of the insulin receptor.

While research in this area is still in the preliminary stage and remains mixed in terms of results, vanadium may help to increase our body's sensitivity to insulin by inhibiting a group of enzymes called protein tyrosine phosphatases.

The protein tyrosine phosphatase 22 (PTPN22) like CTLA - 4 is an inhibitor of T cell activation.

Currently there are several known genes associated with Hashimoto's thyroiditis: cytotoxic T - lymphocyte associated antigen 4 (CTLA - 4), human leukocyte antigens (HLA), protein tyrosine phosphatase 22 (PTPN22) and thyroglobulin receptor gene.