Sentences with phrase «protein variants»

Here's a gene that's central to how nerve cells communicate with each other, so it's curious to us to see a grossly different protein variant.

The combination of 20 different building blocks — amino acids — results in an enormous variety of theoretically possible protein variants; many more than the estimated number of stars in the universe.

These mutations are inserted into batches of yeast or bacterial cells, which express the altered gene and produce millions of random protein variants.

Our proposal represents the kind of research I am interested in, which seeks to modify natural protein variants to be used as therapeutic options for human brain diseases.

If they're all firing at once, suddenly the number of combinations of protein variants in play is really massive.»

«Our group is currently working on determining the high resolution molecular structures of the truncated prion protein variants associated with familial human CAA in order to gain a complete atomistic understanding of the factors underlying their transmission, and the present study is a major stepping stone in this effort,» Jaroniec said.

The regulation is based on a process known as alternative splicing, through which the building blocks of the messenger RNA (mRNA) can be combined in different ways, which can lead to the formation of several protein variants from a single gene.

By combining Cochran's protein engineering know - how with Baer's expertise in laser - based instrumentation, the team created a tool that can test millions of protein variants in a matter of hours.

«There are a few protein variants that are common in New Bedford Harbor killifish, but uncommon elsewhere.

Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland.

This process known as «alternative splicing» and allowing a single gene to generate multiple protein variants is especially prevalent in the mammalian brain.

Thus by studying thousands of protein variants belonging to the same family and identifying the pairs of compensatory mutations, the scientists were able to infer which groups of amino acids were likely in the same structural domain, even if they were far away along the sequence.

Alternative splicing affects most mammalian genes, and effectively enables the production of distinct protein variants (called isoforms) from the same gene.

The researchers created a large library of MphR protein variants and screened them for the ability to switch on production of a fluorescent green protein when they were in the presence of a desired macrolide.

Alternative splicing is a process of generating multiple transcripts and protein variants by joining different combinations of coding segments.

As the epidemic progressed and the virus began rapidly infecting people in Hong Kong, fewer spike protein variants turned up.

Humans have found so many alternative uses for these molecules — as foods, industrial enzymes, anti-cancer drugs — that scientists are eager to better understand how to engineer protein variants designed for specific uses.

Now, they've demonstrated that a single amino acid — known by its number along the protein chain, 139 — is the key to this prion protein variant adopting a «human - like» versus a «hamster - like» structure, while another amino acid, 112, governs the structural differences between the human and mouse versions of the protein.

The scientists were thus able to transfer the genetic information from the known fluorescent protein eqFP615 into the DT40 chicken B cell line in order to produce protein variants of the new infrared marker Amrose with different spectral properties.

The Dorus Gadella lab has recently developed a synthetic red fluorescent protein variant they call mScarlet.

psq is a widely expressed gene that by alternative splicing gives rise to several protein variants that share a PSQ DNA - binding motif (Weber et al. 1995; Horowitz and Berg 1996; Lehmann et al. 1998).

In 2008, Ohio State researchers and their partners at Case Western Reserve University performed the initial solid - state studies of the relevant prion protein variant, and narrowed the list of possibly critical amino acids for its function to about 30.

His lab recently pinpointed a protein variant that can be targeted to prevent the human immunodeficiency virus from harming HIV - positive individuals.

Similarly, the protein variants that are most common at the nearby reference sites are much less common in the New Bedford Harbor killifish.»

The slide bearing these million yeast or bacteria, and the protein variants they produce, is inserted into the µSCALE device.

When genetic material is introduced into these cells, this evolutionary mechanism can be co-opted to create new genetic and protein variants.

Shi and colleagues don't yet know why this protein variant should help the virus kill brain cells, too.

There is simply no such thing as «the best recipe «for this packable delicious meal, but we'll provide you with our favorite one — an easy - to - prepare high - protein variant that will keep you full and happy throughout the day!