Sentences with phrase «proteins cadherin»

These findings suggest that the therapeutic protein was able to interact normally with its binding partners among the USH1 molecular complex (the proteins cadherin 23, protocadherin 15, myosin VIIA and harmonin), as required for the mechanoelectrical transduction apparatus of the hair bundle to function correctly.

Not exact matches

Researchers genetically engineered mice to produce cadherin, a protein involved in learning that helps strengthen the brain's neural connections.

Dr. Menko, together with first author Caitlin Logan, MD, PhD, and second author Caitlin Bowen, was looking at a mouse that had been engineered to stop producing a key developmental protein called N - cadherin just as the lens was beginning to form.

The groundbreaking study identified a protein, known as cadherin - 22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

The culprit in the condition, called aortic valve stenosis, is cadherin - 11, a binding protein necessary for normal wound healing.

The U of G researchers found that it is precisely under conditions of low oxygen that cancer cells trigger the production of cadherin - 22, putting in motion a kind of protein boost that helps bind cells together, enhancing cellular movement, invasion and likely metastasis.

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

Through further testing, they figured out that when Notch1 is activated and its intracellular domain is released, its TMD assembles a complex in the membrane with the proteins VE - cadherin, Rac1, LAR, and Trio, which collectively assemble and maintain the adherens junctions between cells and distribute actin fibers against the cell membrane to support those junctions.

The researchers learned that the astonishing diversity of cadherin in pink bollworm from India is caused by alternative splicing, a novel mechanism of resistance that allows a single DNA sequence to code for many variants of a protein.

In the lab strains, the scientists had identified mutations in a gene encoding a protein called cadherin.

Further experiments revealed that cadherins, proteins that keep cells joined to each other, are required for entosis.

Researchers at the Mechanobiology Institute have comprehensively described the network of proteins involved in cell - cell adhesions, or the cadherin interactome.

Central to adherens junctions is a protein known as E-cadherin, or epithelial cadherin.

Up - regulated expression of zonula occludens protein - 1 in human melanoma associates with N - cadherin and contributes to invasion and adhesion.

While learning how to culture rhinovirus C, Palmenberg's research team discovered the virus only infects certain lung cells that express a particular genetic form of a cell - surface molecule called cadherin - related protein 3 (CDHR3).

ICAM - 2 regulates vascular permeability and N - cadherin localization through ezrin - radixin - moesin (ERM) proteins and Rac - 1 signalling.

Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells.

CNRQ values were calculated by classic delta - delta - Ct method and normalized to the multiple housekeeping genes, cadherin - associated protein, beta 1 (CTNNB1) and GAPDH using the qBasePlus 1.3 analysis software.

Amphimedon cadherins differ from those of Monosiga in having proteins with domain architectures diagnostic for the metazoan - specific classical cadherin and seven pass transmembrane cadherin subfamilies31, 35.

To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal - associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13).