Sentences with phrase «proteins signal the cells»

If not removed, special milk proteins signal the cells to make less milk.

Not exact matches

Immunotherapy differs from more traditional cancer treatments, such as surgery (cutting malignant cells out of the body), chemotherapy and radiation (poisoning the deadly mutants), and even the newer, more precise molecular drugs that attempt to jam the protein signals that tell tumor cells to keep dividing and conquering.

Protein is hugely important for our body - it aids in muscle repair, speeds up chemical reactions and plays a role in cell signalling.

When you or your child comes in contact with egg proteins, immune system cells (antibodies) recognize them and signal the immune system to release histamine and other chemicals that cause allergic signs and symptoms.

Previous studies showed that, in depressed patients, lipid rafts sequester a protein involved in cell signaling, called GαS, keeping it from doing its job.

But to coax them down a specific path in the lab requires recreating the precise sequence and timing of environmental cues in the womb — the signals from proteins and hormones that tell cells what kind of tissue to become.

The protein expressed by the gene is thought to bind to serotonin receptor molecules and ferry them to the cell surface, positioning them to receive serotonin's signals from neighboring cells.

Taking a closer look, the team found that the onset of sepsis disrupts the normal activity of specific interferons, signaling proteins used for communication between immune system cells.

Further study revealed that these so - called immune proteins are actually present on the surface of certain nerve cells, but that they functioned differently in the brain than they did in the rest of the body; rather than scouting for germs, they influenced signals sent between neurons.

Further experimentation showed Lagasse that if he injected hepatocytes directly into the lymph nodes, the cells picked up signaling proteins (essentially SOS signals to grow) released into the bloodstream from the dying liver.

In an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replication.

For example, a protein in a cell might start life in the nucleus and then move into the cytoplasm to take part in cell signaling.

Among these was the protein VGLUT1, which is essential for signal transduction in specific nerve cells.

Ixekizumab is a monoclonal antibody - a cloned antibody - which neutralises the inflammatory effects of an interleukin (IL) a protein in the skin which carries signals to cells - known as (IL)-17 A.

Weissman's research in mice had revealed that cancer cells produce large quantities of CD47, a protein that signals immune cells to spare the cancer cells.

Chinnaiyan and colleagues then conducted studies using cancer cells and found that the different FGFR fusion proteins all seemed to drive cancer cell proliferation by activating FGFR signaling.

The exceptional cancer cells that escape the astrocytes do so by producing a protein called Serpin, which acts as a sort of antidote to the death signals fired at them by nearby astrocytes.

Thus, signals coming from a given neuron provide information about odors that activate the specific receptor protein expressed by that cell.

The researchers found that, in response to the maximum tolerated doses of several commonly used chemotherapy drugs, breast cancer - associated fibroblasts secrete large amounts of cell signaling proteins called ELR + chemokines.

In research that has implications for diabetes and other metabolic diseases, an international study based at UT Southwestern Medical Center found that the protein connexin 43 (Cx43) forms cell - to - cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.

A team led by Carnegie's Wolf Frommer has revealed how membrane proteins were networked with each other and with the signaling proteins inside the cell.

The circuit Hasan's group has discovered consists of three types of nerve cells — one set senses and reports the lack of protein in food, a second set integrates this input with metabolic information and the third set controls the hormonal signals necessary to begin pupation.

King hypothesizes that proteins that the single - celled ancestors of animals used to interact with the extracellular environment — to capture bacterial prey by binding to their cell surface and to detect chemical signals — were later repurposed to enable cells to stick to and talk to each other.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

University of Washington researchers have found that a calorie - restricted diet reduces the activity of a cell - signaling protein called TOR - 1 that may speed up cell aging.

By analyzing chemical changes of the IRS - 2 protein in immortalized cultures of human white blood cells, it determined that IRS - 2 appeared in two different forms — «on,» which allows the signal to pass through, and «off,» which stops the signal from activating the cells into M2 macrophages.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

«The protein travels by diffusion through the cells like electrical signals travel through the brain,» Zeng says.

The new research, reported Nov. 25 in the Journal of Biological Chemistry, investigated the role of two proteins, GRB10 and p70S6K, in the control of the signaling pathway that activates M2 cells.

Some transmembrane proteins receive or transmit cell signals.

Inside your cells, proteins allow your body to break down food to power your muscles, send signals through your brain that control the body, and transport nutrients through your blood.

Designed for use in spinal fusion surgery of the lower back, Infuse consists of a titanium cage that houses a collagen sponge soaked in bone morphogenetic protein (BMP), a growth factor that signals bone - forming cells to produce new tissue.

One key player may be a «motor» protein that shuttles molecular signals through a cell's cytoplasm, Yale University pediatric cardiologist Martina Brueckner and colleagues report in the 30 October issue of Nature.

Several target molecules have also been identified in intracellular signalling pathways and in cell survival proteins.

In CML cells, Gab2 amplifies the signal of the protein Bcr - Abl.

Researchers still don't know how this range corresponds to their versatile functions, but being more like a string than like a lump with keyholes means that a protein can make many contacts with other molecules to regulate the network of signals that drives the cell.

Through their signaling prowess, IDPs help regulate the gas and brake pedals for producing proteins from the DNA code, according to evidence that has accumulated over the past decade, as well as the process by which cells divide.

Dr. Katrin Busch from Rodewald's team developed genetically modified mice by introducing a protein into their blood stem cells that sends out a yellow fluorescent signal.

And the cells of the SCN no longer produced six small signaling proteins known to coordinate and reinforce their efforts, a biochemical process known as coupling.

But little is known about how ionizing radiation affects the extracellular matrix (ECM), a patchwork of proteins and other biomolecules that surrounds cells and plays a vital role in their shape, movement and signaling functions.

The result, published January 5 in Science Immunology, suggests that the protein, a receptor involved in immune cell signaling, plays a role in spontaneous abortions and other human pregnancy complications.

In the new study, Bohn's group used cell signaling assays on a library of µ - receptor - activating compounds to find a few with hints of a bias toward G - protein signaling.

A specific genetic marker influences response to therapy in the early stages of RA; a link thought to be due to the gene activating a cell - signalling protein involved in the inflammatory disease process.

In mammals, proteins called ion channels embedded in the cell membrane translate temperature information into electrical signals that activate nerve cells.

«We also found that reduced cohesin led to changes in the expression of genes involved in nerve cell development and the response to an immune signaling protein,» corresponding author Toshihide Yamashita says.

When activated by inflammatory markers in the gut, it sends a signal to the brain, where immune cells produce proteins such as IL - 6, leading to increased metabolism (and hence decreased levels) of the «happiness hormone» serotonin in the brain.

With more than 800 members in the human genome, GPCRs are the largest family of proteins involved in decoding signals as they come into the cell and then adapt the cell's function in response.

Each of the four families had a distinct mutation that affected a different region of the CARD11 protein, but all the mutations had similar effects on T - cell signaling.

One of the four new reported loci is expected to lower the protein expression of UBASH3A, a molecule that regulates T - cell signaling and correlates with lowering the risk of primary sclerosing cholangitis.

Nose hypothesized that the Toll proteins on M13 cells provide a signal that tells the M12 neuron to stay away.