Sentences with phrase «proteins someone encode»

By restoring protein encoded by PARD3 levels, both, cell lines and animal models of mice, we observed that regulating de novo polarization of cells, significantly reduced the risk of metastasis.

In humans and other animals, RNA editing creates diversity in certain classes of proteins encoded by the nuclear genome.

Identification of physicochemical selective pressure on protein encoding nucleotide sequences.

During their growth the modified cells produce protein encoded by the introduced genetic information.

This does not target the actual mutated protein encoded by the FOP mutation, a receptor in the BMP signaling pathway, but another molecule interacting with its signaling pathway.

Identification of physicochemical selective pressure on protein encoding nucleotide sequences Wong, W. S. W., R. Sainudiin, and R. Nielsen.

With the support of the Wellcome Trust to address this prospect, we have assembled a diverse team of researchers to explore the ultrastructure, biophysics, biochemical activities and cell biology context of cytoskeletal proteins encoded in «Asgard» genomes.

Once inside cells, they are taken up by cellular protein - making machinery and induce the production, over weeks, of the viral proteins they encode.

They found that the mutations individually appeared to have no effect: The P - gp proteins encoded by each gene variant were just as proficient at pumping drugs out of cells.

Functional perilipins (PLIN proteins encoded by the PLIN genes)(Lu et al., 2001) have been identified in very diverse organisms such as Drosophila (Teixeira et al., 2003), Dictyostelium (Du et al., 2013) and fungi (Wang & St Leger, 2007) and protein databases list clear orthologues in diverse, non-plant eukaryota, including the simplest metazoan Trichoplax adherens, sponges, crustaceans, and choanoflagelates (UniProt proteins B3RRM2, I1GA14, G5DCP6, F2UJD9, respectively).

Larsen used 3D modeling to show that Alu insertions within the TOMM40 gene could make the channel protein it encodes fold into the wrong shape, causing the mitochondria's import machinery to clog and stop working.

From an extensive search of information about the unique proteins encoded in the genome of P. fluorescens UM270, a list of 17 genes (among many other) emerges form the genome comparison with the other strains, with activities that may be relevant in the rhizosphere, biocontrol and other plant - bacteria interactions.

This type of «killer» T cell responds to previously encountered cell - surface molecules — including the fragments of SIV proteins encoded by the genes in the CMV / SIV vaccine — and destroys SIV - infected cells.

Although antimicrobial peptides are not the only functional class to be overrepresented among short, secreted proteins encoded by members of multi-gene families, the prevalence of these properties among induced genes strongly suggests the possibly that at least some of these genes encode novel immune effectors.

In addition, we have also used here proteins encoded by alternative sequences at the GNCA node (common ancestor of Gram - negative bacteria).

While useful methods exist for the prediction of functional variants within protein encoding exons (covering only 2 % of the human genome), the prediction of cis - regulatory variants (CRVs) remains an ongoing challenge.

Similar regulation of the synthesis of adenovirus fiber and of simian virus 40 - specific proteins encoded by the helper - defective Ad2 + SV40 hybrid viruses Ad2 + ND5 and Ad2 + ND4del

CARM 1 promotes nuclear export of special class of RNAs (3/15/15) Assistant Professor Donghang Cheng, Ph.D. in Dr. Mark Bedford's group was the co-corresponding author on a study demonstrating that in the absence of the arginine methyltransferase CARM1, a certain class of protein encoding RNAs remain in the nucleus.

She believes that if we understand how a virus's proteins encode information about how to enter and hijack specific cells, we will identify its Achilles heel and be able to stop viral infections.

Many of the new proteins encoded by pseudogenes could also be traced in other cancer cell lines, and the next objective on the researchers» agenda is to investigate if these genes in the» junkyard» of the genome play a role in cancer or other diseases.

At yet, there is a well - kept secret: for thousands of the roughly 20,000 — 30,000 proteins encoded in the genome it is not clear what they do in the body, which function they have.

This does not target the actual mutated protein encoded by the FOP mutation, a receptor in the BMP signaling pathway, but other molecules interacting with its signaling pathway.

EggNOG functional classification of proteins encoded on the three sequenced genomes.

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.

Both gene products have conserved roles in mitochondrial assembly (mitochondria are made up of 2,000 proteins encoded by the nuclear genome and 13 encoded by the mitochondrial genome), mitochondrial integrity and DNA metabolism.

In theory, blocking the production of proteins encoded by these genes could delay or prevent people becoming ill.

Identifying the genes allows us to determine the proteins they encode — proteins that might serve as targets for therapies for a wide range of disorders, from sleep disturbances to seasonal depression.

The system had come full circle: in flies, whose clocks are the best understood, the CLOCK protein — in combination with a protein encoded by a gene called cycle — binds to and activates the per and tim genes, but only if no PER and TIM proteins are present in the nucleus.

Within individual SCN cells, specialized clock genes are switched on and off by the proteins they encode in a feedback loop that has a 24 - hour rhythm.

The new method, which places the proteins encoded by the reprogramming genes directly into the target cells, should be safer.

The discovery was important, Roses says, because the protein encoded by TOMM40, called Tom40, is crucial to healthy mitochondria.

Other teams are trying to introduce the proteins encoded by the genes directly into cells, while Yamanaka is experimenting with «microRNAs» — snippets of RNA that help regulate gene activity.

Some of these genes are involved in making the proteins encoded by the viral DNA and may make it easier for Mimivirus to co-opt host cell replication systems.

But research published in this month's issue of the Journal of Clinical Investigation shows that newborn mice, instead of being immunized to the protein encoded by a DNA vaccine, actually learn to tolerate it.

The mammalian counterparts of Glo, known as heterogeneous nuclear ribonucleoprotein (hnRNP) F / H proteins, bind to RNAs containing stretches of guanine nucleotides known as G - tracts, and, rather than repressing translation, mammalian hnRNP F / H proteins regulate processes such as RNA splicing, in which RNAs are rearranged to produce alternative versions of the proteins they encode.

The cell produces the protein encoded by the vaccine, then shuttles it to the cell surface, where the host's immune system recognizes it as foreign and mounts an immune response.

They don't know the purpose of the protein it encodes.

Previously, the predominant theory has been that the spotty leaves occur due to an imbalance between the amount of particular chloroplastic proteins encoded in the nucleus and chloroplastic proteins encoded in the chloroplast.

Researchers had already unearthed evidence that plasminogen activator inhibitor type 1 (PAI - 1), the protein encoded by the gene, influences aging - related illnesses.

Researchers would then have to pore through four or five databases for each one, trying to discern which genes (or the proteins they encode) have features most likely to affect the biology of the disorder — a painstaking task.

Researchers have figured out important connections between genes and the proteins they encode and have scoured the genome for associations between particular genetic mutations and diseases.

RNA is much more than the mundane messenger between DNA and the protein it encodes.

Working in a tiny mustard plant called Arabidopsis, which is used as a genetic model and shares many of the same genes as other plants and crops, he and his team of biologists discovered that the proteins encoded by the four genes they discovered repress the development of stomata at elevated CO2 levels.

What's more, only a very small percentage (6 %) of proteins encoded by Pandoravirus salinus are similar to those already identified in other viruses or cellular organisms.

A rare and improbable mutation in a protein encoded by an influenza virus renders the virus defenseless against the body's immune system.

L2 plays an important role in cells by activating mRNA decay, a system cells use to turn off gene expression when the proteins encoded by the mRNAs are no longer needed.

Along with evidence that the protein encoded by fru is present in only 500 of the fly's 10,000 central nervous system cells and that it is a transcription factor — a protein that turns other genes on or off — the finding suggests that fru is a high - level regulatory gene that somehow gets specific brain centers to coordinate male courtship behavior, the scientists say.

«During the early evolution of insects, this gene and the protein it encoded changed so that they now turned off those genes required to make legs, essentially removing those legs from what would be the abdomen in insects.»

«We have developed a bioinformatics approach that suggests that such changes might alternatively occur through changes in the interactions of proteins encoded by the gene.»