Sentences with phrase «proven in clinical trials»

That's how efficacy is proven in clinical trials with continuous use of the diffuser (24 hours a day) allowing the dog to constantly perceive the «comforting messages».

Efficacy is proven in clinical trials with continuous use of the collar (24 hours a day) allowing the puppy to constantly perceive the «comforting messages».

That's how efficacy is proven in clinical trials with continuous use of the collar (24 hours a day) allowing the dog to constantly perceive the «comforting messages».

That's how efficacy is proven in clinical trials with continuous use of the diffuser (24 hours a day) allowing the cat to constantly perceive the reassuring messages.

Not only is the efficacy of Vetsulin proven in clinical trials, Vetsulin also offers veterinary practitioners the added security and confidence that comes from over 20 years of successful use by veterinarians worldwide (under the brand names Vetsulin ® and Caninsulin ®).

All of today's approved cancer treatments were first proven in clinical trials.

They say that low - fat weight - loss diets have proved in clinical trials and real life to be dismal failures, and that on top of it all, the percentage of fat in the American diet has been decreasing for two decades.

Not exact matches

The drug, with the unwieldy name ceftolozane / tazobactam, has completed Phase 3 clinical trials and could prove particularly effective in dealing with pseudomonas — bacteria usually acquired in hospitals that cause serious interabdominal and urinary tract infections, ultimately resulting in death in some cases.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

The combo proved non-inferior to competing HIV medicines in a slew of late - stage clinical trials, and Gilead is expected to file a new drug application with the FDA soon.

So in 2016, HVMN — known as Nootrobox at the time — set out to prove itself by testing one of its supplements, a «cognitive enhancement» called SPRINT, against caffeine in a landmark clinical trial.

As we explained in our ASCO primer, pharma giants like Merck (mrk) and Bristol - Myers Squibb (bmy) and biotechs like Juno (juno) and Kite Pharma (kite) had a lot to prove through their clinical trial updates on experimental immunotherapies.

However a lesser known berry — the gooseberry — has now been used in clinical trials to prove its reduction in cardiovascular diseases.

(Culver City, CA April 8, 2014)-- On the heels of a 2013 double - blind clinical trial which proved Axiom Food's Oryzatein ® plant - based brown rice protein equals animal - based whey in building and repairing muscles, Oryzatein has now become the very first brown rice protein to be granted GRAS approval.

Many experts throughout history, including Hippocrates, considered and prescribed phytochemicals as medications and clinical trials have proven the effectiveness of many in enhancing health states.

In recent years, medical researchers have proven its efficacy in clinical trialIn recent years, medical researchers have proven its efficacy in clinical trialin clinical trials.

While they were able to block DOT1L directly using an inhibitor substance currently being tested in a clinical trial for a different type of leukemia, a direct drug - based inhibition of MLL proved impossible.

The compound, already proven safe for humans, is undergoing further animal testing in preparation for possible clinical trials in cocaine addicts, the researchers say.

The method is relatively new, but far bacteria - based vaccines have proven effective: A seasonal flu vaccine produced by VaxInnate successfully protected humans in clinical trials, and the company's recently tested swine flu vaccine immunized mice against the virus.

«UDCA has been in clinical use for decades and thus could be advanced to the clinic rapidly if it proves beneficial in clinical trials.»

An experimental drug for treating the syndrome has proven ineffective in clinical trials.

One clinical trial involves the drug CGF166, a one - time gene therapy, which, if proven successful in humans, could regenerate new hair cells within the cochlea that can signal the part of the brain that processes sound.

Several compounds that boost glutamate signalling in the brain have reached early clinical trials, although it is too soon to say if they will pass the larger trials needed to prove their worth.

But vaccines that only contained HIV's surface protein looked lackluster in animal and test tube studies, and then proved worthless in large - scale clinical trials.

The team is optimistic about CGP3466B because it has already been shown to be nontoxic and nonaddictive in phase I clinical trials that explored its use for Lou Gehrig's and Parkinson's diseases — though it did not prove effective in treating those conditions.

On its own, DON has shrunk tumors in clinical trials of people with a variety of advanced cancers, but its damage to the gastrointestinal system, a glutton for glutamine, ultimately proved too toxic for humans, say the scientists.

A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).

The supplement they took has yet to be proved in large clinical trials, while scientists who have studied it have been caught in the cross fire between converts, willing to take the supplement on faith and anecdotal evidence alone, and skeptics who look askance at all alternative medicine.

Dr Elliott, who is part - funded by Parkinson's UK, said: «If this kind of drug proves to be successful in clinical trials, it would have the potential to bring long - lasting relief from PD symptoms and fewer side effects than existing levadopa therapy.»

Inosine has also been administered in human clinical trials for multiple sclerosis and Parkinson's disease and has been proven to be safe in doses up 3000 mg / day.

While a postdoctoral fellow at the Naval Medical Research Institute in Bethesda, he developed a system for large - scale efficient culture of lymphocytes that has proved to be the foundation for over 35 early phase clinical trials of adoptive immunotherapy.

The clinical trial will attempt to prove that the surgery is safe in young children and allow researchers to study how the brain develops over time and how it learns to hear sound and develop speech.

It was also the first drug to prove that lowering cholesterol could prevent recurrent heart attacks compared to a placebo in a randomized clinical outcomes trial.

If the drugs prove safe and effective in those clinical trials, they could then become available for general use by physicians.

If the chemical proves successful in clinical trials, it will provide doctors with a much - needed drug to fight this form of cancer.

Dr Nakano said: «Many randomised clinical trials, such as Treating to New Targets (TNT) and PROVE IT - TIMI, have shown that aggressive cholesterol lowering with statins improves clinical outcomes in patients with CAD and high LDL - C levels.1, 2 But until now it was not known whether aggressive lipid lowering with statins would also benefit CAD patients with very low LDL - C levels.»

Roughly 20 percent of patients with age - related macular degeneration suffer from abnormal blood vessel growth and vascular leakage, says Campochiaro, and so may be helped by this new therapy, if it proves to work in clinical trials.

The improvement in accuracy could prove very powerful in a large clinical trial, he says, but it's not reliable enough to provide a prognosis for a single patient.

Despite encouraging evidence from animal studies that it clears amyloid from the brain, when it came to clinical improvements in human patients the drug proved no better than placebo in two phase III clinical trials.

Clinton said figuring out which combinations of proven prevention strategies will work best in a given locale will require more research, noting that the U.S. government recently has invested $ 50 million on clinical trials to address these questions.

Promising outcomes of preliminary studies in patients in Southeast Asia and parts of Western and Central Africa led the World Health Organization to make the recommendation, but safety and efficacy have not yet been proven in large - scale clinical trials.

Then they'd have to conduct clinical trials to prove zinc chelation in the retina is safe and effective in people with other conditions, such as glaucoma.

Topamax, an epilepsy drug from Ortho - McNeil Pharmaceutical, has proven extremely effective on migraines in clinical trials: Half of all patients have reported a 50 percent reduction in the frequency of migraines, and more than a quarter have a reported 75 percent reduction.

This prospective, single - arm, phase II clinical trial was conducted to evaluate the safety, feasibility, and efficacy of induction chemotherapy followed by SABR in 34 patients who had biopsy - proven PDA.

Janda said clinical trials to prove efficacy can not be done in humans due to botulinum neurotoxicity dangers.

In a new commentary, scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, argue that the results of three large clinical trials definitively prove that the benefits of starting ART early in infection outweigh any theoretical risIn a new commentary, scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, argue that the results of three large clinical trials definitively prove that the benefits of starting ART early in infection outweigh any theoretical risin infection outweigh any theoretical risk.

Innovative clinical trial approaches that have proven successful in other disease areas such as oncology (e.g., platform trials, umbrella and basket designs) might be employed with stratification of subjects by AT (N) profile, enabling a data - driven approach to identify the biological stage of disease in which an intervention has maximal treatment effects.

PHILADELPHIA --(April 19, 2018)-- The Wistar Institute and partners at the Perelman School of Medicine at the University of Pennsylvania, Inovio Pharmaceuticals, and GeneOne Life Science were recognized among the Top 10 Clinical Research Achievement Awards by the Clinical Research Forum for their ground - breaking phase 1 DNA - based Zika vaccine research — the first trial of a Zika vaccine in humans, which proved safe and effective.

A therapy only reaches the point where it can be evaluated in a clinical trial after it proves successful in animals and the laboratory.

In the course of a twenty - year clinical trial this substance, which is a Vitamin A derivative, has already proven its efficacy in triggering the reduction of breast cancer in women below 40 (50 % reduction) and in non-menopausal women (40 % reductionIn the course of a twenty - year clinical trial this substance, which is a Vitamin A derivative, has already proven its efficacy in triggering the reduction of breast cancer in women below 40 (50 % reduction) and in non-menopausal women (40 % reductionin triggering the reduction of breast cancer in women below 40 (50 % reduction) and in non-menopausal women (40 % reductionin women below 40 (50 % reduction) and in non-menopausal women (40 % reductionin non-menopausal women (40 % reduction).