Sentences with phrase «provide cell lines»

We also provide cell lines for use in the manufacture and testing of vaccines.

Cheng, an assistant professor of medicine in hematology / oncology at Feinberg, provided the cell lines and NanoFlare targets the researchers used to model blood samples taken from breast cancer patients.

Not exact matches

Senator Bernie Sanders (I — VT) has said he believes stem - cell research «represents an exciting and promising line of research that could provide treatments and cures for many debilitating diseases.»

The finding, Shahrara said, provides «strong evidence» that the binding of CCL28 to joint - lining cells carrying its corresponding receptor is a necessary step in angiogenesis.

The 78 stem cell lines in existence would qualify for government - financed research, he said, but no additional money would be provided for additional cell lines.

A study combining tumor cells from patients with breast cancer with a laboratory model of blood vessel lining provides the most compelling evidence so far that a specific trio of cells is required for the spread of breast cancer.

Provide example data from experiments using PD - L1 positive tumors and a cancer cell - line engraftment into a humanized mouse model that was used to test anti-PD1 immune therapy

Human tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human cancers.

The researchers hope their new cell lines will be a useful resource for studying the cellular and molecular intricacies of Huntington's further, and suggest they may provide a model for examining other diseases of the brain that are specific to humans.

The inflammatory processes also activate fibroblast - like synoviocytes (FLS), specialized cells that line the inside of joints providing lubrication and repairing joint injuries.

One of the gene areas identified suggests that cells within the lining of the uterus play a larger - than - expected role in the length of pregnancy, which in turn provides a new target for medications to help prevent preterm birth.

The transplanted stem cells had differentiated into endothelial cells — which form the inner lining of a blood vessel, providing a barrier between blood and spinal cord tissue — and attached to capillaries in the spinal cord.

This environment includes endothelial cells (the cells lining the inside of blood vessels) and extracellular matrix (ECM) components, which provide structural support and signaling to surrounding cells.

Additionally, the latent provirus integrated in the J - Lat cell lines encodes the GFP gene, providing a fluorescent marker of HIV - 1 transcriptional activity.

The immortalized endothelial cell lines established from H - 2Kb - tsA58 mice provide, for the first time, a cell culture system to examine factors regulating angiogenesis and tumor cell arrest in different organ systems.

These cells line the mucosa, where they allow helpful substances to pass through to tissues in the body and also provide a barrier against harmful substances.

a publically available portal for researchers in life sciences and provides access to protein profiling data in 46 normal tissues, 20 cancer tissues, 46 cell lines and on a subcellular level.

These lines would allow scientists to better study conditions ranging from diabetes to Parkinson's disease, and they would provide the basis for potential patient - specific stem cell treatments.

Fluorescent transgenic ES cell lines - PCR assays are provided for the marker transgene.

In effect, the new guidelines provide an incentive to private research entities to obtain so - called «leftover» embryos from fertility clinics and derive stem cell lines from them in order to obtain NIH research dollars to study the derived lines.

Cell lines provides solution for manufacture of therapeutic and diagnostic protein and for applications in drug screening, pharmacological research and toxicological studies

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

These knockout cell lines provide valuable insights into protein functions that may not be obvious due to inefficient knockdown using shRNAs / siRNAs.

• ES cell line purity verification In addition to mouse strain purity verification, the facility provides genetic screening of ES cell lines used for gene targeting experiments.

Thirdly, the current, almost universal dependency of organoid culture on the use of Matrigel as a replacement for the function of the extracellular basement matrix in providing structural support and survival signals to the epithelial cells hampers clinical application, considering its origin from a mouse sarcoma cell line, its poorly defined composition and its mechanical rigidity after plating.

He added: «Truly naive human ES cell lines would not only help answer fundamental questions about how we are made, and be useful for drug screening and tissue therapy, but they would also provide a benchmark against which other types of stem cells could be measured in terms of their effectiveness in stem cell therapy and regenerative medicine.»

Now located at The Centre for Phenogenomics, the CMMR provides fee - for - service access to its range of services and the publicly available mouse lines and ES cells in its repository.

Consequently both effector cells can operate in tandem, with NK cells providing a first line defense killing target cells that escape CTL recognition or show inadequate expression of self - MHC 142.

The Cellartis iPSC CRISPR / Cas9 Gesicle and Single - Cell Cloning System provides an efficient and effective method to generate clonal lines of edited hiPS cells.

It also provides new insights into how the epithelial cells that line the body and its organs stick together.

Eliminating these constraints, hepatocytes differentiated from human induced pluripotent stem (hiPS) cells provide an unlimited supply of functional hepatocytes from each parental cell line, which can be derived noninvasively from a diseased or healthy person.

Persomics now provides CRISPR based screening tools for CAS9 expressing cell lines, and we are currently working to extend this.

Here, we provide evidence that mTOR signaling phosphoproteins, including mTOR, eukaryotic initiation factor 4E — binding protein - 1, p70S6K, and ribosomal protein S6, are highly phosphorylated in ALK + ALCL cell lines and tumors.

Other demonstration found that Cyclin D1 staining could provide significant prognostic information, under the experimental study modulation of MCF - 7 cell line growth rate by regulated overexpression or suppression of endogenous Cyclin D1 or CDK4 levels.

These results provide the validity to the newly developed hypoxia / reoxygenation culture system for examining the regulation of CSCs in breast cancer cell lines by niche factors in the tumor microenvironment and developing differential targeting strategies to eradicate breast CSCs.

We are the home of the UK Stem Cell Bank which provides a world - leading resource of ethically - sourced, quality - controlled human embryonic and other stem cell lines for research applicatiCell Bank which provides a world - leading resource of ethically - sourced, quality - controlled human embryonic and other stem cell lines for research applicaticell lines for research applications.

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard...

The CRUK Accelerator Award is an infrastructure grant that's providing us with five years of funding to help us set up these stem cell lines.

HuH - 7 (human HCC), HepG2 (human hepatocellular blastoma), 293T (human embryonic kidney fibroblast), HeLa (human cervical cancer cells), NIH 3T3 (murine fibroblast), and HCT116 (human colon cancer) and its derived cell line HCT116 p21 − / − (kindly provided by Dr. B. Vogelstein, Howard Hughes Medical Institute, Chevy Chase and the Sydney Kimmel Comprehensive Cancer Center of the Johns Hopkins University School of Medicine, Baltimore, MD; ref.

Registration of cell lines in hPSCreg will provide visibility, confidence in ethical provenance, validation of characterization data and comparability with other registered lines.

Mice derived from requested cell lines via Microinjection services will be pathogen tested prior to delivery of mice and health reports will be provided.

The first line of defence is the innate system, made up of specialised cells that provide a rapid response that is not tailored to the specific microbe that has infiltrated the body.

In this way embryo - derived stem cell lines and ES cell differentiation may be providing access to potential «transition states,» required for lineage specification in vivo.

The Coriell Institute provides information about stem cells and holds a considerable collection of tissue samples, cell lines and pluripotent stem cells.

ATCC is a private organization that provides standard reference microorganisms, cell lines and other materials for research in the life sciences

Combining this with recent advances in genome editing techniques such as the clustered regularly interspaced short palindromic repeat (CRISPR) system has provided an ability to repair putative causative alleles in patient lines, or introduce disease alleles into a healthy «WT» cell line.

The main argument in defence of publishing the HeLa genome was that the cell line was too different from the original cells to provide any information on Henrietta Lack's living relatives.

Analysis of patient - derived iPSC cell lines has revealed the effect of patient mutations on firing patterns of re-programmed neurons and cardiomyocytes, providing indications for clinical intervention.

The LNCaP cell line, in turn, had been likely infected with XMRV from 22Rv1 cells in the same laboratory in which 22Rv1 cells were previously used, or in another laboratory at the Cleveland Clinic that was working with both cell lines and had initially provided the LNCaP cells for analysis.

The European Collection of Cell Cultures (ECACC) provides the research community with a rich collection of cell liCell Cultures (ECACC) provides the research community with a rich collection of cell licell lines.