Sentences with phrase «provides preclinical»

Biomedcode is a highly innovative Contract Research Organization (CRO) which provides preclinical drug evaluation services to small and large pharmaceutical companies worldwide.

Together, this translational program is developed within the National Cancer and Cognition Platform (CNO / Ligue Nationale contre le cancer), with the aim to collaborate in a structured way with French oncology groups, research teams as well as pharmaceutical industry, by providing preclinical models and guidance on standard operating procedures for ancillary or future studies in identified population at risk.

The Bancroft laboratory was funded by TBVAC2020 to provide preclinical animal models to evaluate new TB vaccine candidates.

Learn how Preclinical Translation Services becomes part of your translational research team by providing preclinical research expertise and services for faculty engaging with industry and other funding agencies.

Not exact matches

These preclinical findings, published online ahead of print in the International Journal of Oncology, provide evidence for a potential therapeutic approach that will restore sensitivity to chemotherapy and improve treatment of inflammatory breast cancer tumors.

«Although this is preclinical work, the strategy warrants further investigation because it holds promise as a simple, economical way to overcome the major limitation of current flu vaccination strategies and may provide broad protection against seasonal and pandemic influenza,» added Elliott.

«These results provide the basis for the potential implementation of 5 - LO - inhibitors as stem cell therapeutic agents for a sustained AML cure, although this must be investigated further in preclinical and clinical studies in humans,» explains Dr. Ruthardt.

Beyond providing important information for SMA trial planning going forward, their results also highlight the importance of carefully validating specific biomarkers in a preclinical trial situation.

The results suggest that worsening anxious - depressive symptoms may be an early predictor of elevated amyloid beta levels — and, in turn AD — and provide support for the hypothesis that emerging neuropsychiatric symptoms represent an early manifestation of preclinical Alzheimer's disease.

New preclinical research provides support to a drug that has been repurposed to possibly treat a rare and extremely disabling genetic bone disease, particularly in children.

Preclinical testing provided evidence that ebselen is safe and tolerable, and it has shown no significant adverse effects in ensuing clinical trials.

The study can be seen in Cell Reports and provides an explanation for why the clinical trials for Alzheimer's disease drugs have failed and gives new light on the discord between preclinical and clinical findings.

Formerly a research leader at CHOP, High pursued groundbreaking preclinical investigations in hemophilia B gene therapy and provided scientific expertise to previous gene therapy trials in hemophilia and other genetic disorders at CHOP before moving to Spark Therapeutics, which was spun off from CHOP in 2013.

Russell Kern, chief scientific officer of the International Stem Cell Corporation in Carlsbad, California, which is providing the cells for and managing the Australian trial, says that in preclinical work, 97 % of them became dopamine - releasing cells.

So similar are the two that researchers at the University of Georgia's Regenerative Bioscience Center have developed the first U.S. pig model for stroke treatments, which will provide essential preclinical data and speed the drug discovery process.

These findings are promising for developing a preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, including altering the course of the disease.

Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care.

The aim of the project is two-fold: to provide evidence about reproducibility in preclinical cancer research, and to identify the factors that influence reproducibility more generally.

Based on these preclinical findings, CRI provides a seed grant for a phase I clinical trial to test the strategy in patients with metastatic renal cell carcinoma.

The HZI will provide expertise and technologies for adjuvants and the preclinical validation of vaccine technologies and candidates in murine systems.

«The preclinical results in our animal models are really exciting and have provided the momentum for me to continue on this project, even after Novartis indicated that it no longer wished to maintain this collaboration.»

Moreover, these preclinical imaging approaches provide the unique opportunity to perform longitudinal studies of the same animal, minimizing experimental variability and number of animals per study.

CRI provides a pilot grant to Jean - Pierre Mach for preclinical studies to test a new cancer immunotherapy strategy using anti-tumor antibody fragments conjugated to antigenic MHC / peptide complexes.

This task will also provide a standard measurement and provide reference data and material for the preclinical evaluation of new vaccines.

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

«We're highly encouraged by these preclinical findings demonstrating the ability of our mRNA vaccine to provide robust prevention of maternal transmission of Zika and protection against congenital defects,» said Giuseppe Ciaramella, Ph.D., Chief Scientific Officer of Moderna's infectious disease - focused venture, Valera, and an author on the paper.

The Wake Forest Institute of Regenerative Medicine (WFIRM) has a unique infrastructure that provides facilities and expertise for translational studies, from basic preclinical findings all the way through Phase 2 clinical trials.

While the long - term safety data for the first generation CXCR4 antagonists are not yet available, several new compounds are under preclinical development in an attempt to provide safer and more efficient treatment options for HIV and cancer patients.

This model offers unique capabilities for preclinical assessment of thrombosis risk in a patient - specific manner, including efficacy testing of anti-thrombotic agents, elucidation of mechanism of action, and, potentially, biomarker identification, all providing a much - needed platform for drug discovery and development.

«Nutrient scavenging by autophagy is a process that tumors hijack to meet their energetic requirements and to provide the necessary cellular building blocks for growth in a stressed tumor micro-environment» said White, «Preclinical models have demonstrated a critical role for autophagy in multiple cancer types.»

«Not only does this research provide compelling evidence for further investigation of immunotherapy for treating stomach cancer, it also provides the first model for preclinical testing of these treatments.»

Biomedcode is a Contract Research Organisation (CRO) providing full preclinical drug evaluation services to the pharmaceutical industry using a unique collection of mouse models of human inflammatory diseases.

The goal of this Center of Excellence is to better define thrombus development in patients with cancer, test the efficacy of novel therapies, develop new preclinical models, and create and expand biorepositories to provide a valuable resource to researchers across Cleveland Clinic.

These new preclinical studies provide support for advancing the Ad26 / MVA prime - boost vaccine candidate into clinical development.

«The findings of this preclinical study contribute significantly to our understanding of SMA and provide further evidence suggesting that our strategy to upregulate SMN with small molecules could be effective,» said Loren Eng, President of the SMA Foundation.

Overall, SR - Tiget represents a multi-disciplinary research environment, which provides a unique blend of scientific expertise in the development of innovative gene and cell therapy strategies, access to relevant preclinical models to evaluate their efficacy and safety, as well as competence in conducting early phase clinical trials.

FUJIFILM VisualSonics, Inc is the undisputed world leader in real - time, in vivo, high - resolution, micro-imaging systems, providing modalities specifically designed for preclinical research.

Material (i.e. vaccine) suitable for preclinical in vivo immunisation studies and vaccine antigen for the assays will be provided by the user.

The study provides compelling, preclinical evidence for using this approach to treat acute HIV infection.

His research group actively collaborates with several pharmaceutical companies to provide valuable preclinical data in animal models for their targeted drugs.

It should also be noted that preclinical and clinical studies provide evidence that six herbal medicines may have beneficial effects for women with polycystic ovarian syndrome symptoms (Arentz 2014), these being:

Work experiences listed on sample resumes of Planning Managers include skills like providing recommendations regarding market potential for new targets including, but not limited to, indication prioritization and fast - to - market strategies, and providing commercial analysis in order to gain partnering opportunities for preclinical stage compounds.

Pain and the Reward Pathway: Preclinical Studies on the Impact of Pain on Opioid - Seeking Behavior Learn about the functional relationship between pain, opioid receptor dysregulation, and motivated and affective behavior, providing new insights into the critical neurochemical and neuroanatomical mechanisms that underlie pain - induced changes in opioid reward and comorbid affective disorders.