Sentences with phrase «providing pharmacodynamic»
They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.
https://www.sciencedaily.com/
These results serve as a rationale for ONC201 single - agent trials in relapsed / refractory acute leukemia, non-Hodgkin's lymphoma, MM and combination trial with dexamethasone in MM, provide pharmacodynamic biomarkers and identify further synergistic combinatorial regimens that can be explored in the clinic.