Sentences with phrase «providing therapeutic targets»
«This protein is one explanation of why women are relatively protected from type two diabetes, despite having more body fat content compared to men at a given weight,» said Samaan, adding that this is important as it provides a therapeutic target to improve muscle responses to insulin to treat and prevent diabetes.
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«Each step in this complicated process provides a therapeutic target,» Greene said.
Not exact matches
This small blood vessel change may provide a new therapeutic target to alter the progression of the disease.
This study provides evidence of a direct effect of AMPK on nicotine withdrawal symptoms and suggests that activating AMPK in the brain could be a therapeutic target for smoking cessation.
This study «provides the first fairly targeted therapeutic opportunity for these patients,» says Susan Shurin, a hematologist and acting director of the Division of Blood Diseases and Resources at the National Heart, Lung and Blood Institute (NHLBI) in Bethesda, Md., noting that it paves the way for new treatments.
«It provides exciting new insights into the complications of spinal cord trauma and gives us the possibility of identifying both imaging biomarkers and therapeutic targets.»
The larger scale Cancer Genome Atlas study provided the information needed to alter proteins or RNA sequences that may act as «drivers» for prognostic biomarkers or therapeutic targets.
«This provides strong evidence that Müller glia are important therapeutic targets for treating degenerative eye diseases,» said Sehwon Koh, Ph.D., who is the lead author of this paper and a postdoctoral fellow in the laboratory of Cagla Eroglu, Ph.D., an associate professor of cell biology and neurobiology at the Duke University Medical Center.
«Overlooked cell key player in preventing age - related vision loss: Tree - shaped retinal cells called Müller glia may provide a new therapeutic target for treating degenerative eye diseases.»
These neurons and the synapses between them are supported by long, tree - shaped cells called Müller glia (in green), which may provide a new therapeutic target for treating degenerative eye diseases.
«Our findings suggest that PRMT5 is a possible prognostic factor and therapeutic target for glioblastoma, and they provide a rationale for developing agents that target PRMT5 in this deadly disease,» says co-corresponding author Robert A. Baiocchi, MD, PhD, associate professor of medicine and a hematologist at the OSUCCC — James who is also collaborating on an Ohio State effort to develop a PMRT5 inhibitor.
«This finding suggests a novel therapeutic target to decrease invasion of tumor cells in patients and may also provide a novel biomarker that could help predict survival of patients with glioblastoma,» explained Israel.
«The major known cancer driver genes are often mutated in the primary tumor and all metastases, and successfully targeting them in therapy could provide widespread therapeutic benefit,» said Townsend.
«This study opens an entirely new area of discovery for many aspects of cell biology and biomedical research — how cancer cells metastasize, for example — and provides many new therapeutic targets,» said senior author Jack Dixon, PhD, professor in the UC San Diego School of Medicine and associate vice chancellor of Scientific Affairs.
The new study, led by Daniel Kelly, M.D., scientific director of SBP's Lake Nona campus, provides fresh molecular insight into heart failure and may eventually lead to new therapeutic targets to prevent or slow progression of the disease.
This discovery provides a new potential therapeutic target.
Findings from this study provide a potential therapeutic target and offer the possibility for developing a treatment.
Determining the individual contributions of each protein will help provide strategic therapeutic targets to change the course of a patient's psoriasis or, at the very least, provide a better understanding of how a change in the regulation of these proteins contributes to skin inflammation and psoriatic disease.
«We believe that the reestablishment of proper cell transport could provide a promising therapeutic target for Huntington's disease, and potentially other neurodegenerative disorders.»
«This improved understanding of the host response to HCV infection, and the HCV entry process, will provide new direction for the development of therapeutic treatments to either heighten this natural response, or generate mimics to target the virus specifically.»
Targeting this «wound response» of cancer stem cells can potentially provide a novel approach for therapeutic invention, said researchers from the National Cancer Institute - designated Dan L. Duncan Cancer Center at Baylor College of Medicine.
In a new study, published online June 6 in Nature, researchers at University of California San Diego School of Medicine and Moores Cancer Center, together with colleagues at Keio University, the University of Nebraska and Ionis Pharmaceuticals describe an innovative new model that not only allowed them to track drug resistance in vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growth.
«These events predict a worse outcome in TNBC patients suggesting that the LINK - A pathway plays a critical role in this disease and may provide wide - ranging therapeutic treatment targets.»
New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
Dr. Qimin Zhan, Principal Investigator of this project and the Director of State Key Laboratory of Molecular Oncology, Chinese Academy of Medical Sciences Cancer Hospital, said, «For sure, the findings of this project provide novel insights into understanding of underlying mechanism for this malignant ESCC, and enable us to explore potential diagnostic biomarkers and drug targets, and to develop useful clinical therapeutic approaches.
«This provides an important proof of principal that drugs that target the stem cells could be therapeutic.»
Second, these regulatory determinants may not always be obvious from reductionist principles, and, thus, the analysis provides unique insight into disease mechanism and potential therapeutic targets.
Thus, CA2 may provide a new target for therapeutic approaches to the treatment of social disorders.
«This genomic information will provide the research community with a powerful tool for uncovering new therapeutic targets and developing better strategies for diagnosing, treating and preventing cancer.»
The identification of genes that are synthetically lethal in β - catenin - activated cancer cells would provide new targets for therapeutic drug design.
This study may provide a potential biomarker and therapeutic targets for glaucoma.
Future investigations on the postsynaptic role of p - tau will be necessary to understand its toxic effects and provide insights into new therapeutic targets for maintaining spine integrity, highlighting the importance of tau toxicity as well as the impact of sex on tau - pathology.
The advancement of the Cas9 - based platform for screening and validation will help further the development of new therapeutic products, and Caribou's CRISPR - Cas9 technology can utilize guide RNAs specific for unique sequences and target a gene at numerous sites and therefore provide enhanced specificity.
Penn Medicine's Hematologic Malignancies Translational Center of Excellence seeks to redefine the diagnostic and therapeutic approach to blood cancers in order to provide more effective targeted therapies.
Martin Carroll, MD and Edward Stadtmauer, MD are leading efforts at this TCE to redefine the diagnostic and therapeutic approaches to blood cancers — including leukemia, lymphoma and myeloma — and provide more effective targeted therapies.
Our aim is to highlight the genetic networks that can impact on DM1 biomarkers to provide new therapeutic targets for treatments by chemical compounds.
The Hematologic Malignancies Translational Center of Excellence (TCE) is a multidisciplinary center that seeks to redefine the diagnostic and therapeutic approaches to blood cancers, including leukemia, lymphoma and myeloma, and provide more effective targeted therapies.
The work provides insights into the future use of TNFR2 as a therapeutic target.
These promised to provide a new therapeutic target for treating obesity, with the researchers finding that they share the fat - burning abilities of brown cells, though they do decrease in number as we approach middle age.
These findings suggest that activation of mTOR signaling contributes to tumor cell survival in ALK + ALCL, thus providing a potential therapeutic target in this lymphoma type.
We believe that leveraging human intuition through creation of a scientific game for drug discovery can not only provide a new avenue to discover therapeutic drugs for protein targets, but can also contribute to the development of new sophisticated algorithms to use in computer aided drug design.
Herein, we describe the Cancer Stem Cells Therapeutic Target Database (CSCTT), the first online database to provide a rich bioinformatics resource for the display, search, and analysis of structure, function, and related annotation for therapeutic targets of cancer Therapeutic Target Database (CSCTT), the first online database to provide a rich bioinformatics resource for the display, search, and analysis of structure, function, and related annotation for therapeutic targets of cancer therapeutic targets of cancer stem cells.
Ipsen will provide funding for targeted research programs carried out at the Salk Institute by researchers on novel therapeutic concepts for the treatment of pituitary adenomas, cancer and neurodegenerative diseases.
The Vanderbilt findings provide «proof - of - concept that targeting an antitumor agent to an intracellular protein may increase antitumor selectivity and improve the therapeutic window for treating naturally occurring cancers,» said first author Jashim Uddin, Ph.D., research associate professor of Biochemistry.
«As more of the pieces are assembled, they provide potential new targets for therapeutic agents.»
These findings establish Frizzled family receptors as disease - relevant receptors for toxin B in the colonic epithelium and provide novel therapeutic targets for treating C. difficile infections.
This 3D proteomics brain data can be integrated with parallel 3D transcriptomic studies to possibly provide insights to interesting targets for either therapeutic intervention or further mechanistic studies.
Targeted therapy will be the way to provide personalised treatment, by selecting therapeutic agents according to a target that has been identified on the patient's own tumour.
Bromodomains have long been a target of cancer therapuetic development, and the YEATS domain may now provide a new avenue for the development of future therapeutic targets.
From a therapeutic standpoint, using biomarkers would help doctors provide targeted care to patients who most closely fit the recommended treatment profile.