A recent
psilocybin study found that this compound from magic mushrooms can help people with life - threatening cancer face death.
Roland Griffiths of Johns Hopkins, for example, who has been doing pharmacological research for more than three decades, never had a project scrutinized as thoroughly by his institution's review board and the FDA as his 2006
psilocybin study was.
They conducted
a psilocybin study into depression which found some measurable improvement after just two doses of the substance.
Not exact matches
The idea failed to gain traction then, but now a number of prestigious researchers are
studying the potential therapeutic uses of LSD,
psilocybin and MDMA.
A subject in a
study of the effects of hallucinogens on brain chemistry recounts her mystical, life - changing experiences under the influence of
psilocybin
Psilocybin has been
studied for the treatment of a variety of mental disorders, including treatment - resistant depression, addiction and end - of - life anxiety.
A dozen human
studies of MDMA, LSD, a powerful African drug called ibogaine and
psilocybin, from so - called «magic mushrooms,» are now under way, testing the once - stigmatized drugs as treatments for not only PTSD, but also cluster headaches and addiction, as well as anxiety and depression in cancer patients.
In animal
studies, repeated dosages of
psilocybin diminish the number of 2A serotonin receptors, which dampens their expression.
In each of the nine patients in the
study,
psilocybin drastically diminished or melted away their compulsions for up to 24 hours, and several remained symptom - free for days.
Brain - imaging
studies have shown that
psilocybin targets areas of the brain overactive in depression.
Griffiths has spent more than 15 years conducting
studies of
psilocybin's capacity to produce profound, mystical - type experiences, treat psychological anxiety and depression and to aid in smoking cessation.
«The counterintuitive finding that extremely difficult experiences can sometimes also be very meaningful experiences is consistent with what we see in our
studies with
psilocybin — that resolution of a difficult experience, sometimes described as catharsis, often results in positive personal meaning or spiritual significance,» Griffiths says.
However, six people reported that their suicidal thoughts disappeared after their experience on their worst bad trip — the latter result coinciding with a recent
study published by Griffiths showing the antidepressive properties of
psilocybin in cancer patients.
Psilocybin seems to influence these particular brain areas,» says Katrin Preller, first author of the
study.
Accompanied by the monitors, volunteers entered «an aesthetic living - room - like environment designed specifically for the
study» with a couch, Persian rug, abstract art on the walls, classical music, and eyeshades and took an unidentified blue capsule that contained either
psilocybin or Ritalin.
The
study was co-authored by University of Alabama Assoc. Prof. Peter Hendricks, who predicts that
psilocybin and related compounds could revolutionize the mental health field.
The UBC Okanagan
study found that 42 per cent of U.S. adult male inmates who did not take psychedelic drugs were arrested within six years for domestic battery after their release, compared to a rate of 27 per cent for those who had taken drugs such as LSD,
psilocybin (commonly known as magic mushrooms) and MDMA (ecstasy).
They have also done a pilot
study on
psilocybin as a therapeutic option in individuals with treatment - resistant depression, and are interested in possible roles for psychedelics in combating mental illnesses or addiction.
The
study found that under
psilocybin, activity in the more primitive brain network linked to emotional thinking became more pronounced, with several different areas in this network — such as the hippocampus and anterior cingulate cortex — active at the same time.
However, while
psilocybin has been shown to affect the brains of mammals including mice, there is little evidence that it affects insects or other invertebrates — barring a famous 1962
study showing that it changes the way spiders build webs.
We are currently
studying the effect of LSD on creative thinking and we will also be looking at the possibility that
psilocybin may help alleviate symptoms of depression by allowing patients to change their rigidly pessimistic patterns of thinking.
Psilocybin — a hallucinogenic compound derived from magic mushrooms — may offer a possible new avenue for antidepressant research, according to a new
study published in The Lancet Psychiatry today.
New treatments are urgently needed, and our
study shows that
psilocybin is a promising area of future research.
The results are encouraging and we now need larger trials to understand whether the effects we saw in this
study translate into long - term benefits, and to
study how
psilocybin compares to other current treatments.»
In the second
study, at New York University (NYU) in New York City, 29 cancer patients randomly received either
psilocybin or niacin, a compound that mimics some side effects of
psilocybin — including a flushed, hot feeling — but without the hallucinogenic properties.
In the Johns Hopkins
study, participants and therapists were told that patients would receive
psilocybin on both occasions and that the dose could vary.
Two long - awaited
studies suggest that the hallucinogenic compound in magic mushrooms,
psilocybin, could do just that.
A new
study, published in Scientific Reports, finds that patients taking
psilocybin to treat depression show reduced symptoms weeks after treatment following a «reset» of their brain activity.
On two separate occasions during the nine - month
study, which is being funded by the Heffter Research Institute, patients are given a silver chalice containing either a
psilocybin pill or a placebo.
«It can be like psychotherapy sped up,» says psychiatrist Stephen Ross, MD, an addiction expert at New York University who is leading a
study on
psilocybin treatment in cancer patients with severe anxiety.
The new wave of research on psychedelics — «version 2.0,» as Dr. Ross calls it — began in the early 1990s, when the Food and Drug Administration (FDA) sanctioned a few preliminary
studies on
psilocybin and MDMA.
«Previous animal and human brain imaging
studies have suggested that
psilocybin may have effects similar to other antidepressant treatments,» explained
study senior author David Nutt, also of Imperial College London.
A
study in which patients were treated for depression with
psilocybin (magic mushroom psychedelic compound) revealed reduced symptoms weeks after the
psilocybin treatment.
For the
study, 20 treatment resistant depression patients received a 10 mg dose of the
psilocybin and a second 25 mg dose a week later.
Two small
studies in this special issue of the Journal of Psychopharmacology looked at the effects of
psilocybin, the active compound in what are commonly called magic mushrooms, on patients with advanced cancer who were experiencing depression and anxiety.
The
studies, from New York University (29 patients) and Johns Hopkins University (51 patients), found that treatment with a single dose of
psilocybin, in combination with psychotherapy, led to an substantial reduction in depression and anxiety symptoms compared to a placebo (a very low dose of
psilocybin.