The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for
psychiatric disease by interfering with the way the brain regulates connections between neurons.
New research led by UC San Francisco scientists has revealed that mutations in a gene linked with brain development may dispose people to multiple forms of
psychiatric disease by changing the way brain cells communicate.
Not exact matches
A whopping 34 percent could «conceive of» killing a patient as a way to end suffering caused
by «
psychiatric disease.»
Govoni says that when patients are treated for
psychiatric disease, the creative impulses often associated with bipolar disorder, dementia, or even depression may fall
by the wayside.
Huntington's
disease is a brain disorder characterized
by the emergence of decreased motor, cognitive, and
psychiatric abilities, most commonly appearing in the mid-30s and 40s.
Anxiety disorders, which are characterized
by an inability to control feelings of fear and uncertainty, are the most prevalent group of
psychiatric diseases.
Scientific explanations for the rise of CFS cases, a phenomenon dating to the mid-1980s, have mostly focused on viruses, but
psychiatric theories have abounded, too, driven primarily
by the Centers for
Disease Control and Prevention, which promoted the idea that CFS was «hysteria» or hypochondria.
Up to that time, genetic counseling had mainly focused on rare
diseases caused
by a single genetic fault, and
psychiatric disorders were not an obvious fit.
Associations between parental
psychiatric disease and violent offending
by children were stronger for female than male children; suicide attempts
by children were comparable regardless of sex.
And even if such a demand existed, there was no evidence that genetic counseling could help patients with
psychiatric disorders, which — like most of the more common
diseases — are caused
by a complex interplay of multiple genes and variants as well as environmental factors.
New studies — prompted
by a renewed interest in potential applications of psychedelic drugs for understanding the brain or even treating some
psychiatric diseases — suggest that far - reaching changes in brain connectivity contribute to the altered states of consciousness and other effects of an acid trip.
Risks for suicide attempts and violent offending
by children were elevated across virtually the entire spectrum of parental
psychiatric disease.
Less than a decade ago, anti-NMDA receptor encephalitis was first identified, a
disease characterized
by inflammation of the brain that causes acute
psychiatric symptoms including psychosis.
Parkinson's
disease affects approximately 7 - 10 million people worldwide and is characterised
by progressive loss of motor function,
psychiatric symptoms and cognitive impairment.
Deisseroth says the technique will help reveal faulty connectivity in neurological and
psychiatric diseases like autism
by making it easier to study brain wiring.
The findings also suggest that identifying the brain circuits affected
by mutated genes linked to
psychiatric disease could help scientists develop more personalized treatments for patients in the future, Feng says.
The study is the result of several years of work
by the Schizophrenia Working Group of the
Psychiatric Genomics Consortium (PGC, http://pgc.unc.edu), an international, multi-institutional collaboration founded in 2007 to conduct broad - scale analyses of genetic data for
psychiatric disease.
«
By studying the genome, we are getting a better handle on the genetic variations that are making people vulnerable to
psychiatric disease,» said Tom Insel, director of the National Institute of Mental Health, which helped fund the study.
Huntington's
disease (HD) is an autosomal dominant neurodegenerative disorder characterized
by motor, cognitive and
psychiatric alterations.
The progressive neurodegenerative disorder Huntington's
disease (HD), which is caused
by a polyglutamine repeat expansion within the huntingtin protein, is characterized
by movement disorders, cognitive impairment and
psychiatric symptoms.
The
disease is characterized
by an insidious onset, followed
by progressive cognitive decline,
psychiatric disturbances, and motor impairment.
By reprogramming human skin cells and other cells from patients with neurologic and
psychiatric diseases into induced pluripotent stem cells (iPSCs) and induced neurons (iN), his work seeks to decipher the progression and mechanisms that lead to brain cell dysfunction.
Exclusion criteria were insomnia caused
by disease or medication, sleep apnea, regular use of hypnotic or psychotropic medication, current psychotherapy, presence of major depression or other serious
psychiatric conditions, or confirmed cognitive impairment.
In Singapore, cancer is still seen as a terminal
disease with little hope of recovery, and there is also a stigma against psychological counselling and
psychiatric support, facilitated
by the general stigma against mental illness amongt both patients and, paradoxically, healthcare professionals.67 Furthermore, a family - centred model of decision - making tends to be predominant in Asian populations, 68 and in Singapore this is further encouraged
by public policy such as healthcare subsidies that are based on a calculation of the immediate family's total income, rather than individual income.69 Beliefs or expectations of the role that the family caregiver ought to play may thus exist and may influence the way individuals respond to the intervention.
Functional expectations of caregivers are often huge with multiple responsibilities such as household chores, emotional support, providing transportation and symptom management.4 As cancer survivorship grows, from 50 % in the 70s, to 54 % between 1983 and 1985, to 65 % in 2009, the illness may become a chronic
disease, further stressing caregivers with a cumulative and unrelenting burden of care and responsibility.5 Psychological morbidity or
psychiatric symptomatology among cancer caregivers is high.6, 7 Levels of distress have also been shown to be higher than those reported
by patients themselves.8
Other studies have shown that the number of
psychiatric disorders a person has is related to life outcomes in young adulthood, 5 and that co-occurring mental disorders, to a small extent, influenced the consequences of anxiety and depression.3, 4, 23 More general personal traits such as childhood temperament and intellectual abilities are other individual factors that may be of importance, 26, 29 but the effects of intellectual function and
psychiatric disease seem independent of each other.25 Our results indicated an influence of family factors, as indicated
by the attenuation of OR in model 3.
Those whose symptoms were unexplained
by organic
disease were reinterviewed
by one of us (MS) and a full history and
psychiatric diagnostic interview17 completed to determine eligibility for inclusion.