In turn, his commitment has changed the study of
psychiatric disease into a molecular field based on rigorous analysis of the action of specific genes and proteins.
By reprogramming human skin cells and other cells from patients with neurologic and
psychiatric diseases into induced pluripotent stem cells (iPSCs) and induced neurons (iN), his work seeks to decipher the progression and mechanisms that lead to brain cell dysfunction.
Not exact matches
Of the thousands of ancestral variants reintroduced
into modern humans, only 41 have been linked in genetic studies to
diseases, such as skin conditions and neurological and
psychiatric disorders, he said.
Today, the paradigm has widened
into a much bigger idea that expands our understanding of
psychiatric disease: A whole host of infections and other unknown triggers lead to the production of antibodies and immune cells that can cross
into the brain.
The findings provide insight
into the biological pathways that may predispose an individual to
disease and could ultimately lead to the development of new therapeutic avenues to treat the five major
psychiatric illnesses.
Together with research
into other immune - related genes in
diseases such as Alzheimer's, the idea that immune processes are involved in some
psychiatric phenotypes is looking ever more solid.
«This study illustrates the potential of gaining fundamental insights
into brain function while helping patients with debilitating
diseases, and provides us with a powerful way of selecting targets based on their connectivity to other regions that can be widely applied to help guide brain stimulation therapy across multiple neurological and
psychiatric disorders.»
Despite the noble efforts of clinicians and researchers, our limited insight
into the roots of
psychiatric disease hinders the search for cures and contributes to the stigmatization of this enormous problem, the leading cause worldwide of years lost to death or disability.
SAN FRANCISCO, CA — April 29, 2012 — Scientists at the Gladstone Institutes have determined how specific circuitry in the brain controls not only body movement but also motivation and learning, providing new insight
into neurodegenerative disorders such as Parkinson's
disease — and
psychiatric disorders such as addiction and depression.
Jin's lab is characterizing basic rules of how the brain executes actions from multiple levels of analysis and providing insights
into action - related neurological and
psychiatric diseases.
Prime objectives in studying neurologic and
psychiatric disorders are to develop discriminating markers and generate data that can provide insight
into disease pathogenesis.