This work should lead to a better understanding of not only neuropsychiatric diseases associated with autoantibodies but also of more common neurological or
psychiatric diseases in which similar protein dysfunction are reported.
There is just one snag: Many
psychiatric diseases in humans may well result from circuitry found only in humans.
In a series of provocative experiments, he has already cured the symptoms of
psychiatric disease in mice.
The new finding is the latest evidence supporting a growing precision medicine model of
psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.
MONDAY, Oct. 6 (Health.com)-- About 44 % of children diagnosed with bipolar disorder continue to have symptoms of
the psychiatric disease in adulthood, according to the first study to follow such children over time.
A SNP in protein HFe that absorbs iron improves brain function in populations that have dietary iron deficiency but greatly increases the risk of
psychiatric disease in populations in which dietary iron is excessive.
Not exact matches
More than a quarter (27 percent) of the doctors said they would kill an elderly person «with medical grounds for suffering but
in the absence of severe physical or
psychiatric disease.»
Of the thousands of ancestral variants reintroduced into modern humans, only 41 have been linked
in genetic studies to
diseases, such as skin conditions and neurological and
psychiatric disorders, he said.
This is demonstrated
in the studies reviewed
in the special issue, which use computational models to examine brain processes, such as learning, emotion, dopamine signaling and information processing, and how processes interact
in deficits underlying
psychiatric disease.
In an e-mail to Nature a few days later, Kogan said that zebrafish might be a useful model organism for
psychiatric disease after all.
«We have discovered a small molecule compound that shows a profound and prolonged effect on autism - like social deficits without obvious side effects, while many currently used compounds for treating a variety of
psychiatric diseases have failed to exhibit the therapeutic efficacy for this core symptom of autism,» said Zhen Yan, PhD, professor
in the Department of Physiology and Biophysics
in the Jacobs School of Medicine and Biomedical Sciences at UB, and senior author on the paper.
The genetic variants associated with asthma have also effects on autoimmune
diseases and other
diseases with an inflammatory component such as cardiovascular
diseases, cancers, neuro -
psychiatric diseases, which strengthens the importance of pleiotropy
in multifactorial
diseases.
The Columbia University researcher describes his quest for HIV
in San Francisco and SARS
in China, the immune cascades that may cause autism, and the infectious roots of
psychiatric disease.
In the second study, Dr. McCoy and colleagues demonstrated the application of this new method to examine the association between symptom dimensions and common genetic variation in psychiatric diseas
In the second study, Dr. McCoy and colleagues demonstrated the application of this new method to examine the association between symptom dimensions and common genetic variation
in psychiatric diseas
in psychiatric disease.
Just as was commonplace a generation ago
in internal medicine, the broad advances
in psychiatric and neurologic neuroscience are driving the development of fundamentally new and exciting treatments for many brain
diseases.
During the past decade we've learned a lot about the function of these newborn neurons, revealing their possible role
in psychiatric and neurological
diseases such as mood disorders, schizophrenia and epilepsy.
Huntington's
disease is a brain disorder characterized by the emergence of decreased motor, cognitive, and
psychiatric abilities, most commonly appearing
in the mid-30s and 40s.
As she reflects on her illness, Cahalan wonders how many people go misdiagnosed or undiagnosed
in a
psychiatric ward as a result of lesser - known neurological
diseases.
Indeed,
psychiatric and neurological disorders are at least as genetically determined, and
in many cases more so, than common
diseases of other organ systems.
«While many patients with Anti-NMDAR Encephalitis present with isolated
psychiatric symptoms, most of these patients subsequently develop,
in a matter of days, additional neurological symptoms which help to make the diagnosis of the
disease.
«The practice of the Wim Hof Method may lead to tonic changes
in autonomous brain mechanisms, a speculation that has implications for managing medical conditions ranging from
diseases of the immune system to more intriguingly
psychiatric conditions such as mood and anxiety disorders,» said Diwadkar, professor of psychiatry and behavioral neurosciences.
«This study convincingly shows that mild trauma has a role
in increasing the risk of dementia and sheds light on the more complex relationship between medical and
psychiatric diseases with TBI
in the development of the future risk of dementias.
Similar disruptions
in pre-pulse inhibition have been noted
in patients suffering from schizophrenia or other
psychiatric diseases.
But nearly a century ago, it was Alois Alzheimer who first described the
disease and
in so doing became one of the first physicians to offer a biological basis for a
psychiatric condition.
That
in turn makes it possible to highlight the exact neural pathways involved
in the various forms of
psychiatric disease.
Many of those duplicated regions overlap parts of the genome implicated
in many
diseases and
psychiatric disorders such as schizophrenia, Carmona - Mora said.
The newly discovered vessels, which were also identified
in human samples, could explain the long - standing conundrum of how the immune system manages to contribute to neurological and
psychiatric disease.
Our new blinded, case - controlled study, published
in Molecular Psychiatry, finds no association between Borna
disease virus and
psychiatric disease.
Dillin noted that drugs that lower levels of serotonin have long been used to treat depression and other
psychiatric manifestations of neurodegenerative
diseases, but the new findings suggest these medications may have more widespread use
in age - related
disease than was previously thought.
New research led by UC San Francisco scientists has revealed that mutations
in a gene linked with brain development may dispose people to multiple forms of
psychiatric disease by changing the way brain cells communicate.
It is perhaps thus likely that that these damaged genes coding for
psychiatric diseases are overrepresented
in women with fertility problems, and, if transferred to their offspring, this may at least partly explain the increased risk of
psychiatric diseases.»
According to Cheyette, this is some of the strongest evidence to date that WNT signaling could play a key role
in driving
psychiatric disease, and that it works through changes
in synaptic communication between neurons.
Dr. Deisseroth is the D.H. Chen Professor
in the Bioengineering and Psychiatry Departments at Stanford University, and is a practicing inpatient and outpatient psychiatrist, employing medications and interventional brain stimulation techniques (VNS, TMS, and others) to treat patients with
psychiatric disease.
The new study — published October 18, 2016
in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human
psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments
in mutant mice to suggest that mutations
in the gene DIXDC1 may act as a general risk factor for
psychiatric disease by interfering with the way the brain regulates connections between neurons.
New studies — prompted by a renewed interest
in potential applications of psychedelic drugs for understanding the brain or even treating some
psychiatric diseases — suggest that far - reaching changes
in brain connectivity contribute to the altered states of consciousness and other effects of an acid trip.
Among the most debilitating and stigmatized
psychiatric diseases, schizophrenia can rob sufferers of their self and their future, often
in early adulthood.
The research provides hope for a future
in which there will be less guesswork
in treating
psychiatric disease.
Together with research into other immune - related genes
in diseases such as Alzheimer's, the idea that immune processes are involved
in some
psychiatric phenotypes is looking ever more solid.
Deisseroth says the technique will help reveal faulty connectivity
in neurological and
psychiatric diseases like autism by making it easier to study brain wiring.
However, it is known to reside
in brain tissue, and has been linked to several
psychiatric diseases, including schizophrenia, bipolar disorder and suicidal behavior.
«Identifying gene variants that are general risk factors for neurological and
psychiatric disease is important, but understanding exactly which cell types
in the developing brain are compromised and what the consequences are is still extremely challenging,» Pollen added.
«To the extent that
psychiatric or neurological
disease is localized to a specific part of the brain, we should now be considering the potentially specialized type of astrocytes regulating nerve connections
in that region and their contributions to
disease,» he said.
As someone who has unfortunately been involved with numerous close relatives (a daughter, a brother and a wife who were given this diagnosis) and having worked
in state
psychiatric wards and witnessed seriously ill schizophrenics firsthand, I am convinced there is organic impairment of some kind responsible for this very painful
disease.
But new research presented at the American Diabetes Association's 74th Scientific Sessions ® shows that symptoms of depression
in people with type 2 diabetes can be significantly reduced through interventions for «diabetes distress,» suggesting that much of what is being labeled as depression may not be a co-morbid
psychiatric disorder after all, but rather a reaction to living with a stressful, complex
disease that is often difficult to manage.
In this paper, Fox led a team that first conducted a large - scale literature search to identify all neurological and
psychiatric diseases where improvement had been seen with both invasive and noninvasive brain stimulation.
For the last decade, neuroscientists have been using the non-invasive brain - mapping technique functional called magnetic resonance imaging or fMRI to examine activity patterns
in human and animal brains
in the resting state
in order to figure out how different parts of the brain are connected and to identify the changes that occur
in neurological and
psychiatric diseases.
In addition, they envision potential applications beyond infectious
disease, including chronic
diseases such as
psychiatric disease, heart
disease, renal
disease and more.
The findings also suggest that identifying the brain circuits affected by mutated genes linked to
psychiatric disease could help scientists develop more personalized treatments for patients
in the future, Feng says.
«Our findings contribute further understanding of the biology of
psychiatric and neurological
diseases and whether autoantibodies detected
in a subgroup of patients can trigger
psychiatric disorders.
On the negative side, the researchers found that many of the genes whose activity is unique to modern humans are linked to
diseases like Alzheimer's
disease, autism and schizophrenia, suggesting that these recent changes
in our brain may underlie some of the
psychiatric disorders that are so common
in humans today.