► The Broad Institute received a huge donation — $ 650 million, the largest ever made for psychiatric research — from philanthropist and businessman Ted Stanley, to study the biological basis of
psychiatric diseases such as schizophrenia and bipolar disorder, Emily Underwood wrote at ScienceInsider.
I had access to my relative risks of
psychiatric diseases such as bipolar disorder and schizophrenia.
Not exact matches
Of the thousands of ancestral variants reintroduced into modern humans, only 41 have been linked in genetic studies to
diseases,
such as skin conditions and neurological and
psychiatric disorders, he said.
This is demonstrated in the studies reviewed in the special issue, which use computational models to examine brain processes,
such as learning, emotion, dopamine signaling and information processing, and how processes interact in deficits underlying
psychiatric disease.
The genetic variants associated with asthma have also effects on autoimmune
diseases and other
diseases with an inflammatory component
such as cardiovascular
diseases, cancers, neuro -
psychiatric diseases, which strengthens the importance of pleiotropy in multifactorial
diseases.
During the past decade we've learned a lot about the function of these newborn neurons, revealing their possible role in
psychiatric and neurological
diseases such as mood disorders, schizophrenia and epilepsy.
These changes affect normal brain processes,
such as development or memory, and abnormal brain processes,
such as depression, drug dependence, and other
psychiatric disease — and can pass down to subsequent generations.
«The practice of the Wim Hof Method may lead to tonic changes in autonomous brain mechanisms, a speculation that has implications for managing medical conditions ranging from
diseases of the immune system to more intriguingly
psychiatric conditions
such as mood and anxiety disorders,» said Diwadkar, professor of psychiatry and behavioral neurosciences.
Many of those duplicated regions overlap parts of the genome implicated in many
diseases and
psychiatric disorders
such as schizophrenia, Carmona - Mora said.
The effects of PTSD on heart
disease remained strong even after researchers accounted for lifestyle factors
such as smoking, physical activity level, and drinking; and major depression and other
psychiatric diagnoses.
And even if
such a demand existed, there was no evidence that genetic counseling could help patients with
psychiatric disorders, which — like most of the more common
diseases — are caused by a complex interplay of multiple genes and variants as well as environmental factors.
Together with research into other immune - related genes in
diseases such as Alzheimer's, the idea that immune processes are involved in some
psychiatric phenotypes is looking ever more solid.
In addition, they envision potential applications beyond infectious
disease, including chronic
diseases such as
psychiatric disease, heart
disease, renal
disease and more.
«Many Huntington's
disease patients experience
psychiatric - related problems,
such as depression and anxiety,» added Supriya Swarnkar, the first author of the study and a member of Subramaniam's lab.
Since then we have tried to generate various types of neurological or
psychiatric disease models
such as a transgenic marmoset model of Alzheimer's
disease.
«Although our goal is to develop systems that can treat infectious
diseases such as malaria, HIV or tuberculosis in sub-Saharan Africa or Southeast Asia, there are many applications here in the U.S. for treating chronic conditions
such as heart
disease, diabetes or
psychiatric illness.
Such discoveries will ultimately point toward rational treatments that address the causes of serious
psychiatric disease, rather than just alleviate the symptoms.
SAN FRANCISCO, CA — April 29, 2012 — Scientists at the Gladstone Institutes have determined how specific circuitry in the brain controls not only body movement but also motivation and learning, providing new insight into neurodegenerative disorders
such as Parkinson's
disease — and
psychiatric disorders
such as addiction and depression.
Such changes in neuronal function are likely to play important roles in all normal physiological processes in the brain and are critical for development of a variety of brain
diseases, including Alzheimer's
disease, Parkinson's
disease, schizophrenia, epilepsy, drug dependence and other neurological and
psychiatric disorders.
Scientists working in computational psychiatry at Brown are thinking about how they can use their work modeling the brain to address
psychiatric disease,
such as depression.
Merzenich is now applying his basic research findings to the development and testing of new tools for improving brain function in people with a range of neurological and
psychiatric conditions,
such as Alzheimer's
disease or schizophrenia, or following brain injury.
Within the fields of microbiology and immunology, neurologic
diseases, neuropharmacology, behavioral, cognitive and developmental neuroscience, and
psychiatric disorders, the center's research programs are seeking ways to: develop vaccines for infectious and noninfectious
diseases; understand the basic neurobiology and genetics of social behavior and develop new treatment strategies for improving social functioning in social disorders
such as autism; interpret brain activity through imaging; increase understanding of progressive illnesses
such as Alzheimer's and Parkinson's
diseases; unlock the secrets of memory; treat drug addiction; determine how the interaction between genetics and society shape who we are; and advance knowledge about the evolutionary links between biology and behavior.
Based on their effect on neurons, as well as their locations in the genome, the researchers think that many of the HARs guide genes involved in brain development, as well as
psychiatric diseases that are uniquely human,
such as autism and schizophrenia.
MONDAY, Oct. 6 (Health.com)-- About 44 % of children diagnosed with bipolar disorder continue to have symptoms of the
psychiatric disease in adulthood, according to the first study to follow
such children over time.
Other neurological and
psychiatric disorders associated with mercury include narcolepsy, obsessive - compulsive disorder, schizophrenia, bipolar disorder, Tourette syndrome and borderline personality disorder, as well as neurodegenerative disorders
such as Alzheimer's
disease, Parkinson's
disease and multiple sclerosis.
It's no mystery, then, why so many people with autoimmune
disease experience comorbid
psychiatric illnesses
such as anxiety and depression, which are inextricably linked to brain inflammation.
Inflammatory molecules stimulate microglia activation, which is commonly found in brains of those with
psychiatric diseases,
such as those of children with autism.
In Singapore, cancer is still seen as a terminal
disease with little hope of recovery, and there is also a stigma against psychological counselling and
psychiatric support, facilitated by the general stigma against mental illness amongt both patients and, paradoxically, healthcare professionals.67 Furthermore, a family - centred model of decision - making tends to be predominant in Asian populations, 68 and in Singapore this is further encouraged by public policy
such as healthcare subsidies that are based on a calculation of the immediate family's total income, rather than individual income.69 Beliefs or expectations of the role that the family caregiver ought to play may thus exist and may influence the way individuals respond to the intervention.
Functional expectations of caregivers are often huge with multiple responsibilities
such as household chores, emotional support, providing transportation and symptom management.4 As cancer survivorship grows, from 50 % in the 70s, to 54 % between 1983 and 1985, to 65 % in 2009, the illness may become a chronic
disease, further stressing caregivers with a cumulative and unrelenting burden of care and responsibility.5 Psychological morbidity or
psychiatric symptomatology among cancer caregivers is high.6, 7 Levels of distress have also been shown to be higher than those reported by patients themselves.8
Other studies have shown that the number of
psychiatric disorders a person has is related to life outcomes in young adulthood, 5 and that co-occurring mental disorders, to a small extent, influenced the consequences of anxiety and depression.3, 4, 23 More general personal traits
such as childhood temperament and intellectual abilities are other individual factors that may be of importance, 26, 29 but the effects of intellectual function and
psychiatric disease seem independent of each other.25 Our results indicated an influence of family factors, as indicated by the attenuation of OR in model 3.
These include physical conditions
such as asthma, diabetes, leukemia and sickle cell
disease as well as
psychiatric and developmental disabilities
such as ADHD and autism spectrum disorders.
More general personal traits
such as childhood temperament and intellectual abilities are other potentially important factors, 15, 52 but the effects of intellectual function and
psychiatric disease seem to be independent of each other.14