Sulforaphane seems to work by interrupting the tiny microtubules that normally
pull pairs of chromosomes apart when cells divide.
Not exact matches
Perhaps most crucially, when cells divide, microtubules form the spindle structure that first aligns the
chromosomes in the middle
of the cell then
pulls them apart, so that each new cell gets one
chromosome from each
pair.
They anchor strands
of protein that attach to replicated
chromosomes and help
pull the
paired chromosomes apart, so that each new cell gets just one copy
of each
chromosome.
Despite this hard work from dynein, in roughly one - quarter
of the cells observed, the spindle was misaligned, even after the
paired chromosomes were
pulled to opposite sides
of the cell in late anaphase.
Before dividing,
pairs of identical
chromosomes line up in the middle
of the elongated cell, and the microtubules, emanating out from the centrioles on either side, help
pull the
chromosomes in opposite directions so that each new cell receives one member
of each
chromosome pair.
As mitosis progresses, the microtubules align the
chromosomes along the mid-line
of the cell, then shorten and
pull the
chromosome pairs at their centromeres to opposite sides
of the cell.