Similar experiments were performed demonstrating that
the purified human antibodies also protected immunosuppressed hamsters against lethal disease caused by Sin Nombre virus.
The purified human antibodies had «potent neutralizing activity against both hantaviruses,» according to the paper's first author, Jay W. Hooper, Ph.D, of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID).
Not exact matches
Sharon used molecular biology methods to express and
purify the virus peptide and NMR spectroscopy to analyze its structure as it is bound to neutralizing
human antibodies.
-- Hyperimmune globulin, prepared by
purifying and concentrating plasma of immunized animals or previously infected
humans with high titers (concentrations) of neutralizing
antibody against Ebola virus, which have been shown to be protective in monkeys but are not currently available and would not be expected before mid-2015.
They show that highly
purified NS1 acts as a pathogen - associated molecular pattern (PAMP) that activates mouse macrophages and
human peripheral blood mononuclear cells (PBMCs) in culture via TLR4, resulting in release of inflammatory cytokines — an effect that was blocked by either a TLR4 antagonist or an anti-TLR4
antibody.
The team collected plasma from the cows,
purified the
human IgG
antibodies, and tested the material for its ability to neutralize the two different viruses.