Wilson's strain, known as J99, was the second H.
pylori genome sequence published in the late 1990s.
Not exact matches
In December 1994,
Genome Therapeutics Corp. in Waltham, Massachusetts, announced that it had sequenced a different strain of H.
pylori.
In 12 biopsies of his remarkably well - preserved gut tissue (and stomach contents), they were able to isolate enough bacterial DNA to sequence the
genome of H.
pylori to relatively high resolution, as they report online today in Science.
His Harvard Ph.D. included the first methods for direct
genome sequencing, molecular multiplexing and barcoding, which led to the first commercial
genome sequence — a pathogen called Helicobacter
pylori.
Their results show that H.
pylori affects both mitochondrial transport systems (used to transfer proteins into mitochondria) and the machinery for the replication and maintenance of the mitochondrial
genome.
Already during her PhD work (1992 - 1996), Nelson was involved in
genome sequencing, among others of Helicobacter
pylori, a bacterium that is considered to be a trigger for gastric ulcers.