Sentences with phrase «pylori induces»
Helicobacter pylori induces hyperproliferation in a three - dimensional culture system in conjunction with up - regulation of ß - catenin target genes.
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The scientists from Berlin now found that while DNA damage induced by other means, such as irradiation or genotoxic chemicals, is indeed random, the damage caused by H. pylori is not.
When considering gastric cancer, another H pylori - induced global killer, the necessity for understanding the pathogenesis of the infection and the role of host genetics in susceptibility is even greater.
The researchers induced small stomach lesions in anesthetized mice and observed that H. pylori bacteria can rapidly detect the injury site and navigate toward it.
High - salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL / 6 mice.
High dietary salt intake exacerbates Helicobacter pylori - induced gastric carcinogenesis.
Our current studies therefore, are not only allowing us to investigate discrete interactions that lead to H. pylori - induced neoplasias but also are providing mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.
Our experiments have recently shown that MMP - 7 is detected exclusively in human mucosa colonized by cag + strains, and these same H. pylori strains selectively induce MMP - 7 in vitro through cag - mediated activation of NF - kB and MAPK.
Extending these results into rodent models of H. pylori - induced inflammation and carcinogenesis (Mongolian gerbils and mice), we have shown that inactivation of such genes attenuates the development gastric injury and cancer.
Host and microbial determinants influence Helicobacter pylori - induced gastric carcinogenesis in a murine model of hypergastrinemia.
Gastric adenocarcinoma is the second leading cause of cancer - related death in the world, and Helicobacter pylori, a bacterial species that persistently colonizes the human stomach and induces chronic gastritis, is the strongest known risk factor for this malignancy.
Chronic inflammatory changes related to gastric Helicobacter pylori infection can also induce parietal cell changes.
They were laughed at when they proposed the idea and had to prove it by swallowing a cocktail loaded with H. Pylori and inducing ulcers in themselves.