Sentences with phrase «pyramidal cells»
"Pyramidal cells" refers to a type of nerve cells found in the brain. They have a pyramid-like shape and play a crucial role in various brain functions, such as learning, memory, and decision-making. Full definition
Then, working with the Janelia Vivarium team, Cembrowski temporarily silenced one type of pyramidal cell in the mouse's subiculum.
janelia.org
Cembrowski and his colleagues wanted to understand the extent of the variation of pyramidal cells in subiculum and, if they could identify distinct subclasses, associate them with differences in information processing.
For their analyses, the scientists specifically colored the places of origin of axons of so - called pyramidal cells in the hippocampus.
Fast - spiking interneurons are part of a general class of neurons whose primary role is regulating the activity of the principal cells of the cerebral cortex, known as pyramidal cells.
This is a major output layer with two distinct pyramidal cell types that are comparatively large, sparse, and easily labeled.
«We found that, during periods of recurrent network activity, cortical pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with the inhibitory potentials synchronously controlling the timing of action potentials.»
A Simulation Study on the Effects of Dendritic Morphology on Layer V Prefontal Pyramidal Cell Firing Behavior Psarrou, M., Stefanou, S.S., Papoutsi, A., Tzilivaki, A., Cutsuridis, V., Poirazi, P. Front Cell Neurosci.
Cembrowski shared some clues as to what's ahead for him and his colleagues: «We have identified suspect number one in terms of what's responsible for the electrophysiological differences between subiculum pyramidal cells and we hope to investigate that, perhaps using gene editing.»
Long - term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR - A — / — mice when GFPGluR - A expression was constitutive or induced in already fully developed pyramidal cells.
A significant reduction in the context - specific modulation of firing rate was observed in the CA3 pyramidal cells when the mutant mice were transferred from one context to another.
They investigated pyramidal cells in the dorsal region of the subiculum — an area linked to the processing of information about the animal's environment — using a multi-pronged approach, integrating methods from cell biology, genetics, circuit analysis, and behavioral neuroscience to zero in on the neural roots of spatial recognition.
With only green pyramidal cells functioning, trained mice that previously bee - lined to the platform now swam helter - skelter.
That work showed that pyramidal cells exhibit two distinct firing patterns in the subiculum — some spiked once, while others spiked in bursts.
Title: 5 - HT1A Receptor Agonists Enhance Pyramidal Cell Firing in Prefrontal Cortex Through a Preferential Action on GABA Interneurons Author: L. Llado - Pelfort et al..
Jan Mulder, Tania Aguado, Erik Keimpema, Klaudia Barabás, Carlos J. Ballester Rosado, Laurent Nguyen, Krisztina Monory, Giovanni Marsicano, Vincenzo Di Marzo, Yasmin L. Hurd, Francois Guillemo, Ken Mackie, Beat Lutz, Manuel Guzman, Hui - Chen Lu, Ismael Galve - Roperh, Tibor Harkany (2008) «Endocannabinoid signaling controls pyramidal cell specification and corticothalamic axon patterning», Proc Natl Acad Sci U S A, 105:8760 - 8765.
We used extracellular field potential recordings to study BST, short - term plasticity (PTP, post-tetanic potentiation; PPF, paired - pulse facilitation) and long - term potentiation (LTP) at the Schaffer collateral - CA1 pyramidal cell synapses in young and old rTg4510 (2 - 3 and 6 - 7 month old) and old APP / PS1 mice (8 - 10 month old).
Effects of Neonatal Undernutrition on Development of the Dorsolateral Prefrontal Cortex Pyramidal Cells in the Rat
The subiculum is the primary «output» for the hippocampus — it sends signals to various brain regions via a special class of neurons called pyramidal cells.
Along the way the signal can be amplified by excitatory neurons such as pyramidal cells (PYRs) or dampened by inhibitory neurons such as SST and PV cells.
Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells.
In addition, they hope to take the spatial recognition experiments to the next level using a new microscopy technology that could show simultaneous activity in both subclasses of pyramidal cells in a freely moving mouse.
BRAIN CANDY A new database offers a deep look at living human nerve cells, revealing elaborate branching structures and myriad shapes, such as in this neuron called a pyramidal cell (cell image, left and 3 - D computer reconstruction, right).
In CA3, distinct subsets of pyramidal cells were activated in each room, regardless of the similarity of the testing enclosure.
A neuron called a pyramidal cell, for instance, has a bushy branch of dendrites (orange in 3 - D computer reconstruction, above) reaching up from its cell body (white circle).
There is nothing extraneous here in this painting of two pyramidal cells, a type of neuron found in the cerebellum and hippocampus.
Pyramidal cells in the isolated CA1 area developed sharp and stable place fields.
One ensemble of these pyramidal cells was shown to transmit information to the amygdala, resulting in a fear response; this ensemble can be inhibited by the chandelier cell.
Neuronal activity is correlated with an influx of calcium ions, which can be tracked with fluorescent dyes or proteins that bind to calcium, as in these pyramidal cells.
Neurons communicate with each other through chemical and electrical signals that can be excitatory (activating) or inhibitory (deactivating), depending on their class: Pyramidal cells are excitatory neurons whilst interneurons are inhibitory.
To trace the paths of the pyramidal cells and see if subclasses of cells could be distinguished based on their downstream targets.
Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys.
Recently, researchers demonstrated that pyramidal cells may exhibit heterogeneity within the subiculum; in other words, subclasses of these cells may relay different signals to different areas of the brain.
These cells, in turn, stimulate other nerves but inhibit their firing, including the pyramidal cells
A cross section of the hippocampus with some pyramidal cells depicted with the major incoming fibres (SC - schaffer collaterals, green), TA (temperoammonic pathway, blue), SH (septohippocampal pathway, black) Figure 3.
The gatekeeper (OLM - alpha2; red) counteract signaling coming from the TA pathway (blue), thereby allowing local inputs from the SC pathway (green) on the pyramidal cell (orange) to become stronger.
For her dissertation, Prerana developed several bacTRAP transgenic mouse lines to characterize molecularly distinct cortical pyramidal cell types, and focused on layer 2/3 pyramidal cell population in the prefrontal cortex that moderate stress induced depression related behavior.