«We found that, during periods of recurrent network activity, cortical
pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with the inhibitory potentials synchronously controlling the timing of action potentials.»
Altered patterning of dentate granule cell mossy fiber inputs onto CA3
pyramidal cells in limbic epilepsy.
In addition, they hope to take the spatial recognition experiments to the next level using a new microscopy technology that could show simultaneous activity in both subclasses of
pyramidal cells in a freely moving mouse.
For their analyses, the scientists specifically colored the places of origin of axons of so - called
pyramidal cells in the hippocampus.
Pyramidal cells in the isolated CA1 area developed sharp and stable place fields.
Not exact matches
BRAIN CANDY A new database offers a deep look at living human nerve
cells, revealing elaborate branching structures and myriad shapes, such as
in this neuron called a
pyramidal cell (
cell image, left and 3 - D computer reconstruction, right).
Long - term potentiation (LTP) induced by pairing or tetanic stimulation was rescued
in adult GluR - A — / — mice when GFPGluR - A expression was constitutive or induced
in already fully developed
pyramidal cells.
A neuron called a
pyramidal cell, for instance, has a bushy branch of dendrites (orange
in 3 - D computer reconstruction, above) reaching up from its
cell body (white circle).
There is nothing extraneous here
in this painting of two
pyramidal cells, a type of neuron found
in the cerebellum and hippocampus.
The new research reveals how spatially intermixed
pyramidal neurons that were associated with single chandelier
cells in the mouse prelimbic cortex segregated into two groups.
A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities
in the interplay of the main excitatory neurons,
pyramidal neurons, and a specific class of inhibitory nerve
cells, called chandelier
cells,
in the prefrontal cortex.
Neuronal activity is correlated with an influx of calcium ions, which can be tracked with fluorescent dyes or proteins that bind to calcium, as
in these
pyramidal cells.
A significant reduction
in the context - specific modulation of firing rate was observed
in the CA3
pyramidal cells when the mutant mice were transferred from one context to another.
To see what was happening
in the brains of these ankyrin - G mutant mice, the researchers analyzed the
cell components
in inhibitory synapses connecting with
pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels
in the synapses on
pyramidal neurons
in ankyrin - G mutant mice than
in normal mice.
They also found that the disruption of the connectivity of these
cells during brain development causes alterations
in brain oscillatory activity and disturbs the function of place
cells, a type of
pyramidal neuron that becomes active when an animal is located
in a particular place
in its environment.
Cembrowski shared some clues as to what's ahead for him and his colleagues: «We have identified suspect number one
in terms of what's responsible for the electrophysiological differences between subiculum
pyramidal cells and we hope to investigate that, perhaps using gene editing.»
Recently, researchers demonstrated that
pyramidal cells may exhibit heterogeneity within the subiculum;
in other words, subclasses of these
cells may relay different signals to different areas of the brain.
The inverse relationship between the amyloid plaque density and
pyramidal cell density
in the AD brain regions also supports this possibility, as does the close correlation between plaque size and the size of local
pyramidal cells.
Serotonin induces excitatory postsynaptic potentials
in apical dendrites of neocortical
pyramidal cells.
A beta 42 first selectively accumulates
in the perikaryon of
pyramidal cells as discrete, granules that appear to be cathepsin D - positive, suggesting that they may represent lysosomes or lysosome - derived structures.
CONCLUSIONS: Our findings suggest that excessive intracellular accumulation of A beta 42 - positive material
in pyramidal cells can result
in cell lysis, and that
cell lysis is an important source of amyloid plaques and neuronal loss
in AD brains.
For her dissertation, Prerana developed several bacTRAP transgenic mouse lines to characterize molecularly distinct cortical
pyramidal cell types, and focused on layer 2/3
pyramidal cell population
in the prefrontal cortex that moderate stress induced depression related behavior.
Morphologic evidence for spatially clustered spines
in apical dendrites of monkey neocortical
pyramidal cells.
We used extracellular field potential recordings to study BST, short - term plasticity (PTP, post-tetanic potentiation; PPF, paired - pulse facilitation) and long - term potentiation (LTP) at the Schaffer collateral - CA1
pyramidal cell synapses
in young and old rTg4510 (2 - 3 and 6 - 7 month old) and old APP / PS1 mice (8 - 10 month old).
Action potentials
in brain neuron (hippocampal
pyramidal cell) before and after blockade of BK - type (potassium) channels.