Sentences with phrase «pyramidal neurons by»

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In GluR - A — deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-- tagged GluR - A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons.

The team, led by CSHL Professor Z. Josh Huang and including researcher Joshua Gordon, M.D., Ph.D., director of the National Institute of Mental Health, focused on dense crowds of excitatory cells called pyramidal neurons — several hundred of which can connect with a single chandelier cell.

Along the way the signal can be amplified by excitatory neurons such as pyramidal cells (PYRs) or dampened by inhibitory neurons such as SST and PV cells.

Finally, these astrocyte - derived neurons typically exhibited morphology reminiscent of pyramidal neurons, displaying synaptic spines that were targeted by pre-synaptic terminals.

At hippocampal excitatory synapses on pyramidal neurons the cannabinoid - induced synaptic suppression was reversed by a CB1 - specific antagonist, N -(piperidin -1-yl)-5 -(4 - iodophenyl)-1 -(2,4 - dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251), and was absent in CB1 knock - out mice.

Similar compelling evidence supporting the existence of bonafide intraneuronal Aβ peptides has been provided by ELISA analysis on laser microdissected pyramidal neurons from sporadic AD cases [63].

At 13 months of age, the intracellular MOAB - 2 immunolabel was hardly detectable in pyramidal neurons adjacent to amyloid plaques, the latter which were strongly labeled by this antibody and not by pab27576 (Additional file3: Figure S2 a-b).

Animal studies have shown that direct glucocorticoid exposure results in a loss of pyramidal neurons and dendritic branching in the hippocampus, meaning that the organic structure of this brain area was affected by this hormone, likely resulting in a decrease neuronal synapses that would facilitate integration.