Dendritic morphology of
pyramidal neurons in the chimpanzee neocortex: Regional specializations and comparison to humans.
Hand R *, Bortone D *, Mattar P, N'Guyen L, Heng JI - T, Guerrier S, Boutt E, Peters E, Barnes, AP, Parras C, Schuurmans C, Guillemot F and Polleux F. (2005) Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of
pyramidal neurons in the neocortex.
Molecular profiles of
pyramidal neurons in schizophrenia.
To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on
pyramidal neurons in ankyrin - G mutant mice than in normal mice.
Not exact matches
In GluR - A — deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-- tagged GluR - A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neuron
In GluR - A — deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-- tagged GluR - A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors
in CA1 pyramidal neuron
in CA1
pyramidal neurons.
BRAIN CANDY A new database offers a deep look at living human nerve cells, revealing elaborate branching structures and myriad shapes, such as
in this
neuron called a
pyramidal cell (cell image, left and 3 - D computer reconstruction, right).
A
neuron called a
pyramidal cell, for instance, has a bushy branch of dendrites (orange
in 3 - D computer reconstruction, above) reaching up from its cell body (white circle).
There is nothing extraneous here
in this painting of two
pyramidal cells, a type of
neuron found
in the cerebellum and hippocampus.
It receives information via the so - called mossy fibres (MF), which originate
in dentate gyrus
neurons and, together with
pyramidal neurons, form synapses
in CA3;
in this case MF - CA3 - synapses.
The new research reveals how spatially intermixed
pyramidal neurons that were associated with single chandelier cells
in the mouse prelimbic cortex segregated into two groups.
Studies of glutamate receptor channels expressed
in cultured hippocampal
pyramidal neurons reveal that these channels are subject to neuromodulatory regulation through the adenylate cyclase cascade.
A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities
in the interplay of the main excitatory
neurons,
pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells,
in the prefrontal cortex.
When they mutated neuregulin 3
in neurons that help activate the brain — called
pyramidal neurons — the genetically modified mice displayed behavior consistent with schizophrenia.
«What we found at the cellular level correlates with the behaviors we saw
in the less - anxious, hyper - active mice, which means having overactive
pyramidal neurons with their brakes removed could be contributing to these behaviors,» says Zhu.
They also found that the disruption of the connectivity of these cells during brain development causes alterations
in brain oscillatory activity and disturbs the function of place cells, a type of
pyramidal neuron that becomes active when an animal is located
in a particular place
in its environment.
Endocannabinoids differentially modulate synaptic plasticity
in rat hippocampal CA1
pyramidal neurons.
At hippocampal excitatory synapses on
pyramidal neurons the cannabinoid - induced synaptic suppression was reversed by a CB1 - specific antagonist, N -(piperidin -1-yl)-5 -(4 - iodophenyl)-1 -(2,4 - dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251), and was absent
in CB1 knock - out mice.
At 13 months of age, the intracellular MOAB - 2 immunolabel was hardly detectable
in pyramidal neurons adjacent to amyloid plaques, the latter which were strongly labeled by this antibody and not by pab27576 (Additional file3: Figure S2 a-b).
Ex vivo cortical electroporation (E15 mouse embryos) coupled with organotypic culture for 5 days results
in radial migration of EGFP +
pyramidal neurons to the cortical plate (CP) and the projection of their axon
in the intermediate zone (IZ).
Isolated excitatory spines annotated from a single cortical
pyramidal neuron with Vaa3D Synapse Detector program developed
in collaboration with the Allen Institute for Brain Science (Unpublished, Dan Iascone)
In particular, what are the molecular mechanisms underlying the ability of long - range projecting
pyramidal neurons and locally - projecting interneurons to form an axon, for these axons to grow and branch and finally find their appropriate synaptic targets?
Synaptic reconstruction of all excitatory inputs made onto a single cortical
pyramidal neuron labeled with sparse
in utero electroporation (Unpublished, Dan Iascone)
Synaptic reconstruction of all excitatory and inhibitory inputs made onto a single cortical
pyramidal neuron labeled with sparse
in utero electroporation.
Effects of sub-threshold activated ion channels on signal integration
in hippocampal
pyramidal neurons
Synaptogenesis and development of
pyramidal neuron dendritic norphology
in the chimpanzee neocortex resembles humans.
Synaptogenesis and development of
pyramidal neuron dendritic morphology
in the chimpanzee neocortex resembles humans.
The electrotonic structure of
pyramidal neurons contributing to prefrontal cortical circuits
in macaque monkeys is significantly altered
in aging..
Behavioral relevance helps untangle natural vocal categories
in a specific subset of core auditory cortical
pyramidal neurons.
Involved
in cannabinoid - dependent depolarization - induced suppression of inhibition (DSI), a process
in which depolarization of CA1 postsynaptic
pyramidal neurons mobilizes eCBs, which retrogradely activate presynaptic CB1 receptors, transiently decreasing GABAergic inhibitory neurotransmission (PubMed: 22388959).
Progressive degeneration of nonphosphorylated neurofilament protein - enriched
pyramidal neurons predicts cognitive impairment
in Alzheimer's disease: a stereologic analysis of prefrontal cortex area 9.
Decreased
pyramidal neuron size
in Brodmann areas 44 and 45
in patients with autism.
Chia - Shan Wu, Jie Zhu, Jim Wager - Miller, Shan Wang, Dennis O'Leary, Krisztina Monory, Beat Lutz, Ken Mackie, and Hui - Chen Lu (2010) «Requirement of cannabinoid CB1 receptor
in cortical
pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections», European J. Neuroscience, 32:693 - 706.
Discovered that Kv7 / M / KCNQ - type K + channels are present
in the perisomatic region but not
in the apical dendrites of hippocampal
pyramidal neurons (Hu et al., J. Neuroscience, 2007).
Action potentials
in brain
neuron (hippocampal
pyramidal cell) before and after blockade of BK - type (potassium) channels.
Immunohistochemical examination of postmortem AD brains revealed that cytoplasmic accumulation of 8 - oxoG is evident
in hippocampal CA1 and CA3
pyramidal neurons, and
in neurons in the temporal cortex, where Aβ is also highly accumulated.
Animal studies have shown that direct glucocorticoid exposure results
in a loss of
pyramidal neurons and dendritic branching
in the hippocampus, meaning that the organic structure of this brain area was affected by this hormone, likely resulting
in a decrease neuronal synapses that would facilitate integration.