Sentences with word «pyridine»

The introduction of a 2,3 - disubstituted pyridine ring with an aminomethyl moiety at the 2 - position led to compound 142 with an IC50 value of 0.021 μM that showed a comparable potency to 131.

«Distant Protonated Pyridine Groups in Water - Soluble Iron Porphyrin Electrocatalysts Promote Selective Oxygen Reduction to Water.»

TPN then becomes negative and at the same time attracts a proton, forming TPNH, the reduced pyridine nucleotide.

Published in Chemical Science, the reaction employs a chiral nickel catalyst and an activating agent at low temperatures to couple nucleophilic arenes, common motifs in bioactive compounds, with a feedstock chemical known as pyridine.

In particular, the effects of sequentially replacing the benzimidazole ring with a substituted pyridine ring, the opening of the tetrahydroquinoline ring, and the combination of both alterations were investigated to optimize potency.

In a ligand that is not preorganized, chemical groups called pyridines face away from each other.

«Field tests have shown that cerium dioxide is an ecologically acceptable alternative to cuprite, a substance that is used as a biocide together with copper thiocyanate and copper pyridine at concentrations of up to 50 percent in anti-fouling coatings,» explained Professor Wolfgang Tremel of JGU's Institute of Inorganic Chemistry and Analytical Chemistry.

«A highlight of the method is being able to use pyridine as a substrate because it's inexpensive and abundant and has rarely been used in transition metal and asymmetric catalysis,» said Abigail Doyle, an associate professor of chemistry at Princeton and corresponding author of the article.

We present a great variety of metasurfaces, from simple metallic hexagonal dots or continuous metallic lines to more complex structures such us raspberry - like bimetallic nanoclusters, all produced using self - assembled thin films of different molecular weight poly (styrene)- b - poly (2 - vinyl pyridine)(PS - b - P2VP) copolymers, synthetized by living anionic polymerization.

Compounds 166 (containing a phenyl moiety) and 167 (containing an exocyclic - pyridine fused group), and the alkyl analog 168, retained activity (EC50 values of 0.040, 0.104 and 0.043 μM, respectively).

Dr. Proctor's Hair Formula Shampoo includes an abundant supply of NANO (3 - carboxylic acid pyridine - N - oxide).

The best result was achieved by attaching a substituted pyridine ring to position 2, according to the previously proposed pharmacophore model [87, 94].

Introducing a nitrogen base preorganizes the system so that pyridines face in the same direction.

Researchers in the Doyle lab at Princeton have developed a direct and selective cross-coupling reaction that employs a chiral nickel catalyst and an activating agent at low temperatures to couple nucleophilic arenes, common motifs in bioactive compounds, with a feedstock chemical known as pyridine.

Analysis of maternal liver at the time of fetal resorption indicates that the observed effects may be mediated through modification of the concentration of the pyridine nucleotide coenzymes.

One of the characteristic features of epibatidine's structure is the chlorine atom which is attached to its pyridine group.

When Daly's team subjected the compound to infrared and nuclear magnetic resonance spectroscopy (NMR), they found that it consists of a pyridine ring with a chlorine atom attached (see Diagram).

Performing transition metal chemistry with pyridine has proven challenging because it can «poison'the nickel catalyst, essentially binding to the nickel such that the reaction can not move forward.

Cooking meat at high temperatures or over an open flame, such as when barbecuing or pan-frying, is known to result in the formation of carcinogens, including 2 - amino -1-methyl-6-phenyl-imidazo (4,5 - b) pyridine (PhIP) and amino -3,8-dimethylimidazo (4,5 - f) quinoxaline (MeIQx).

Finally, the replacement of the pyridine ring with a pyrazine moiety (compound 164) conferred an antiviral potency comparable to that of the benzyl analogue 157.

Furthermore, since AMD070 and related (S)- enantiomers were previously demonstrated to have a significant increase in potency, representative compounds from the pyridine 142, the thiophene 146 and the furan 149 series were synthesized as the (S)- enantiomers, resulting in compounds with an IC50 value of 4.2, 1.0, and 0.3 nM, respectively.

P1 behavior was first investigated by STM at the liquid / solid interface: as an exemple, an arrangement of the molecules on HOPG presenting a quasi-square lattice (a = 2.1 nm, b = 2.2 nm, α = 94 °) self - assembled by hydrogen bonds between the pyridine unit and the methyl groups borne by the p - xylene core will be described, indicating strong intermolecular interactions between the molecules P1 leading to a supramolecular self - assembly independent of the underlying HOPG structure.

In addition, the complexation of P1 with complementary entities (palladium II dichloride, terephtalic acid and 1,4 - diodobenzene) to form supramolecular network was also investigated by infrared spectroscopy in solid state, the coordination with PdII beuing observed by as strong shift of the C - N bond stretching of the pyridine unit compared to the pedestal alone (1591 → 1609 cm - 1).

Among the 14 synthesized compounds (89 - 102), the unsubstituted pyridine analogue 89 was three-fold less potent than the reference compound with an IC50 value of 15.3 nM (versus 5 nM of AMD070), while methyl pyridine derivatives were more active.

The pH - dependent absorption and emission were then studied for P1: the first protonation of the pyridine unit could be easily observed with an isobestic point a 350 and 419 nm, respectively, but the second protonation was just slightly detected and its isobestic point could not be accurately estimated.

Isoxazole substitutions of the pyridine core of sazetidine - A produced a few high - affinity compounds, but generally reduced ligand activity and were abandoned.

From stable NH - triazoles, the one - pot procedure generates carbenes using triflic anhydride, a pyridine base, and a rhodium catalyst (J. Am.

Using sazetidine - A as a template, medicinal chemists developed multiple series of novel ligands with modifications to the pyridine core, azetidine ring, and alkynyl side chain with the objective of designing α4β2 - nAChR partial agonists of high specificity.

Third, GRM5 promoter is less methylated in CPA and Navarro et al. showed that 2 - methyl - 6 -(phenylethylnyl) pyridine (MPEP), a selective antagonist of GRM5, has anti-aggressive effects in mice [93].