Sentences with word «pyrimethamine»

Daraprim, known generically as pyrimethamine, is used mainly to treat toxoplasmosis, a parasite infection that can cause serious or even life - threatening problems for babies born to women who become infected during pregnancy, and also for people with compromised immune systems, like AIDS patients and certain cancer patients.

Imprimis provides a version of pyrimethamine, the active part of Daraprim, combined with leucovorin, a form of B - vitamin folic acid that's recommended to treat toxoplasmosis.

Sulfadoxine - pyrimethamine went next, in the 1960s.

They'd finally managed to make pyrimethamine, the active ingredient in Daraprim.

For humans, drugs such as pyrimethamine and sulfadiazine, plus folinic acid can be used.

He's hired a crisis PR firm, and run into another pharmaceutical company that has decided to market a competing drug to Turing's pyrimethamine (known on the market as Daraprim) for $ 1 per dose.

Chloroquine was replaced by sulphadoxine - pyrimethamine (SP), but resistance to SP subsequently emerged in western Cambodia and again spread to Africa.

If your baby is also infected or is likely to be, the doctor may recommend sulfadiazine and pyrimethamine, but only after the 16th week of pregnancy.

Former mainstay drugs (chloroquine and sulfadoxine — pyrimethamine) also experienced their first resistance challenges in western Cambodia before spreading to other parts of Asia and on to Africa, where the parasites killed millions.

Preventative treatment of malaria is a useful strategy to protect young children in Africa, but it is unclear which drug and dosing strategy is most effective, especially with the rise of resistance to a class of drug known as antifolates, such as sulfadoxine - pyrimethamine (SP) and trimethoprim - sulfamethoxozole (TS).

For reasons still unclear, resistance to older malaria drugs — including chloroquine and sulfadoxine - pyrimethamine — emerged in Pailin as well and then spread broadly, Plowe points out.

A novel strategy to screen pregnant women for malaria with rapid diagnostic tests and treat the test - positive women with effective antimalarials does not lower the risk of adverse pregnancy outcomes compared with treating all pregnant women with the malaria preventive sulfadoxine - pyrimethamine (SP) in sub-Saharan Africa, according to an open label randomized trial published this week in PLOS Medicine by Feiko ter Kuile, of the Liverpool School of Tropical Medicine, and colleagues.

By the late 1980s, some Asian strains were impervious not only to chloroquine but also to sulfadoxine - pyrimethamine, a low - cost alternative to chloroquine, mefloquine, and quinine.

Cambodia's western border has long been the cradle of antimalarial drug resistance: Chloroquine, sulphadoxine - pyrimethamine, and mefloquine all met their match there before becoming useless elsewhere in the world.

Pregnant women and their unborn children are at a high risk for complications from malaria infection, and finding new treatment options is important because the malaria parasites are becoming increasingly resistant to the existing WHO - recommended drug sulphadoxine - pyrimethamine (SP).

A few tweaks to dhps and dhfr, the genes targeted by sulfadoxine and pyrimethamine, and the drug can no longer stick to its targets.

Resistance to other malaria drugs, namely chloroquine and sulfadoxine / pyrimethamine, first developed in Southeast Asia before spreading to Africa.