In high carbohydrate diet - induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase / DLD in striated muscles, as well as that of selected glucose /
pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (PubMed: 26671069).
Not exact matches
«We now know much more about
metabolic reprogramming of cancerous tissues in human patients, particularly that the activation of
pyruvate carboxylase is important to lung cancer cell growth and survival,» said Fan, UK professor of toxicology and faculty member of the Markey Cancer Center and CESB at the University of Kentucky.
Metabolic profiling indicates impaired
pyruvate dehydrogenase function in myalgic encephalopathy / chronic fatigue syndrome.
The «HIF - 1 signaling pathway» also inhibits Tricarboxylic acid cycle through the inhibition of circuits that trigger the effector protein PDHA1 with diverse GO annotations such as tricarboxylic acid cycle, acetyl - CoA biosynthetic process from
pyruvate or carbohydrate
metabolic process
This pathway allows glutamine to be converted into a variety of
metabolic intermediates such as aspartate, asparagine, citrate and oxaloacetate and
pyruvate [103].
Researchers have long been aware of the capacity of
pyruvate — a highly common organic acid present in many
metabolic reactions throughout the body — to provide us with antioxidant support.