Sentences with phrase «quantitative trait»
A "quantitative trait" refers to a characteristic or feature of an organism that can be measured and expressed numerically. For example, height, weight, or blood pressure are quantitative traits because they can be easily observed and measured using numbers. Full definition
For quantitative traits such as yield, many genes and many environmental factors collectively determine trait performance.
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This is, in modern - day terms, a modestly powered study of complex quantitative traits.
The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.
Our first striking observation was that over one half of measured genes are affected by common genetic variation in human populations — called expression quantitative trait loci or eQTLs.
They then used a genetic technique called quantitative trait locus analysis to search for the genes involved in generating phenolics in the most promising progeny.
• Describe how protein quantitative trait loci (pQTLs) can provide insights into disease biology and improve the efficiency of drug development
Phylogenetic ANOVA: The Expression Variance and Evolution Model for Quantitative Trait Evolution Rohlfs, R. V. and R. Nielsen.
We also assess performance in real 16S data, where we reanalyze previous genetic association data to show that relative to other widely used quantification methods Karp reveals a larger number of microbiome quantitative trait association signals.
Adaptation in quantitative traits likely often occurs through subtle shifts in allele frequencies at many loci, a process called polygenic adaptation.
Gibbs sampling - based segregation analysis of asthma - associated quantitative traits in a population - based sample of nuclear families.
Simulating the yield impacts of organ - level quantitative trait loci associated with drought response in maize: A «gene - to - phenotype» modeling approach.
As it is well known that hypertension is a complex, multifactorial, quantitative trait under a polygenic control, 30 % to 50 % of the variation in blood pressure between individuals is attributed to genetic factors, and the genes responsible for susceptibility and blood pressure variation are mostly unknown.
In the lab, we created a hybrid cross between two genera that differ in microhabitat in the wild and behavior in the lab, and used a ddRAD - seq linkage - mapping strategy to identify quantitative trait loci (QTL) associated with species - specific behaviors.
Now, as a postdoctoral researcher at the University of California, Davis, I am continuing to investigate the evolutionary forces shaping variation by studying if and how local adaptation contributes to quantitative trait variation in domesticated maize.
- Reviewer 1 for the Proceedings of the Royal Society of London starts with The point is so elementary that it does not require a manuscript of this length to develop it but then goes on to prove he / she doesn't get the point by saying that Although many quantitative traits are indeed normally distributed, there is no fundamental reason why this should be so and in particular why it should be so for lifespan.
Today, many ecological and evolutionary studies depend on a wide range of molecular tools to infer phylogenetic relationships, uncover population structure within species, and track quantitative traits.
We examined 152 SNPs in 71 candidate genes for association with diabetes status and related phenotypes in 2,134 Caucasians in a case - control study and an independent quantitative trait (QT) cohort in the United Kingdom.
«Structural Model Analysis of Multiple Quantitative Traits,» by Renhua Li et al., PLoS Genetics, 2006.
Hip and elbow dysplasia have been reported as quantitative traits occurring in numerous breeds (Leighton et al, 1977, Swenson et al, 1997, Mäki et al, 2002).
They then used a genetic technique called quantitative trait locus analysis to search for the genes involved in generating phenolics in the most promising progeny.
Phylogenetic ANOVA: The Expression Variance and Evolution Model for Quantitative Trait Evolution.
We identified 1209 protein quantitative trait loci (pQTL) with overwhelming majority of local pQTL and only 5.8 % of distal pQTL.
We also assess performance in real 16S data, where we reanalyze previous genetic association data to show our method discovers a larger number of quantitative trait associations than other widely used methods.
His research interests include the molecular underpinnings of cervical cancer (including developing genetic screens), the identification of the genetic determinants of quantitative traits in humans, and the application of massively parallel sequencing technology for understanding the genetics of complex disease.
Melek Kayserili Erkut (Tomancak, MPG)-- «Investigating evolutionary divergence and quantitative traits in population of early Drosophila melanogaster embryos» (2014)
Saturday, Oct. 21, 11:20 - 11:40 a.m., South Hall B, South Building Featured Plenary Abstract: Massively parallel reporter assays combined with cell - type specific expression quantitative trait loci profiling identified a functional melanoma risk variant in HIV - 1 inhibitor gene, MX2 J. Choi, National Cancer Institute, et al
IRRI scientists have identified several key regions of the rice genome — called quantitative trait loci (QTLs)-- that give the rice drought tolerance and improve rice grain yield under such conditions.
Led by a team of world - renowned geneticists, our solutions are applicable for questions focused on single - nucleotide polymorphism discovery and diagnostics, marker - assisted selection, quantitative trait locus mapping, genome - wide association studies, phylogenomics, and more.
Engelhardt's group was responsible for mapping associations between genetic variants and gene expression levels on different chromosomes, a connection known as «trans - expression quantitative trait loci (trans - eQTLS).»
These regions can be clumped into larger areas of the genome called quantitative trait loci, which are known to contain genes that produce a specific physical effect, such as shaggy hair.
The exciting aspect of submergence was that they could bring in what is known as a «quantitative trait locus» — a more genetically complex region that influences measurable changes to the crop.
Number of genes controlling a quantitative trait in a hybrid zone of the aposematic frog Ranitomeya imitator.
Number of genes controlling a quantitative trait in a hybrid zone of the aposematic frog Ranitomeya imitator Vestergaard, J. S., E. Twomey, R. Larsen, K. Summers, and R. Nielsen.
Alpha - haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of beta - thalassaemia.
Bentolila, S., Babina, A. M., Germain, A., and Hanson, M. R. (2013) Quantitative trait locus mapping identifies REME2, a PPR - DYW protein required for editing of specific C targets in Arabidopsis mitochondria.
In the past three years, dozens of genetic variants and Quantitative Trait Loci (QTL) have been identified which influence breed - defining traits including those for skeletal size [2], coat color [3], [4], leg length [5], hairlessness [6], wrinkled skin [7], hair length, curl, and texture [8], and presence of a dorsal fur ridge [9].
Coupled with the dog domestication bottleneck, this likely simplified the genetic architecture of quantitative traits, including complex disease phenotypes that are not fixed within breeds and were not the subject of selection for novelty.
These types of studies yielded thousands of expression quantitative trait loci (eQTLs), along with insights into how genetic variation influences transcription.
In the last decade, genome - wide association studies (GWAS) enabled by cheap, high - throughput SNP genotyping have identified thousands of loci that influence disease susceptibility, quantitative traits, and other complex phenotypes.