Sentences with phrase «quiescent hematopoietic»
To gauge the effect off the loss of imprinting control on the maintenance of the quiescent hematopoietic stem cell pool, Venkatraman analyzed the numbers of quiescent, active and differentiated hematopoietic stem cells in mouse bone marrow.
https://www.sciencedaily.com/
She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.
«A large number of quiescent hematopoietic stem cells was activated simultaneously when the epigenetic control provided by genomic imprinting was removed,» explains Venkatraman.
Not exact matches
Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.
We know, for instance, that even very pure hematopoietic stem cells could have 40 - 90 % of quiescent fraction but engraft differently or in similar rate - different pathways working and different molecular signature.