While it is generally accepted that MSC are mostly
quiescent during postnatal life, MSCs in different niches can presumably differentiate into the specific
cells of closely related niches during physiological turnover, injury or disease, as shown for other
stem cell types (e.g.,
muscle satellite
cells).
Using mouse skeletal
muscle stem cells as a model, we show that accumulating transcripts specifying the myogenic program are not translated in
quiescent satellite
cells, but are repressed by the action of microRNAs and RNA binding proteins.
Title: An adult tissue - specific
stem cell in its niche: A gene profiling analysis of in vivo quiescent and activated muscle satellite cells Authors: Pallafacchina G, François S, Regnault B, Czarny B, Dive V, Cumano A, Montarras D, Buckingham ME Date: 2009 Publication Details: Stem Cell Resea
stem cell in its niche: A gene profiling analysis of in vivo quiescent and activated muscle satellite cells Authors: Pallafacchina G, François S, Regnault B, Czarny B, Dive V, Cumano A, Montarras D, Buckingham ME Date: 2009 Publication Details: Stem Cell Resea
cell in its niche: A gene profiling analysis of in vivo
quiescent and activated
muscle satellite
cells Authors: Pallafacchina G, François S, Regnault B, Czarny B, Dive V, Cumano A, Montarras D, Buckingham ME Date: 2009 Publication Details:
Stem Cell Resea
Stem Cell Resea
Cell Research.