Sentences with phrase «radial glia»

Early in his career he discovered that previously enigmatic support cells, known as radial glia, serve as guides for the migration of cortical neurons in the developing brain, and showed how this process is critical for the organisation of the multilayered structure of the cerebral cortex.
Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus.
Fong Kuan Wong (Huttner, MPG)-- «Generation of basal radial glia in the embryonic mouse dorsal telencephalon» (2014)
Until recently, most of what scientists knew about this process came from studies of model organisms such as mice, where nearly all neurons are produced by stem cells called ventricular radial glia (vRGs) that inhabit a fertile layer of tissue deep in the brain called the ventricular zone (VZ).
In 2010, Kriegstein's lab discovered a new type of neural stem cell in the human brain, which they dubbed outer radial glia (oRGs) because these cells reside farther away from the nurturing ventricles, in an outer layer of the subventricular zone (oSVZ).
An image of tissue that's grown in a dish shows radial glia stem cells that are red, neurons in blue and the AXL receptor in green.
And once radial glia are finished helping neurons move around the developing brain, they don't die.
Notch signaling is essential for radial glia stem cell proliferation and a determinant of neuronal number in the mammalian cortex.
Early in his career, he discovered that previously enigmatic support cells, known as radial glia, serve as guides for the migration of cortical neurons in the developing brain, and showed how this process is critical for the organization of the multi-layered structure of the cerebral cortex.
oRG stem cells are extremely rare in mice, but common in primates, and look and behave quite differently from familiar ventricular radial glia.
The gene activity profiles also provided several novel insights into the biology of outer radial glia.
One kind, called radial glia, serve as a scaffolding in the embryonic brain.
One of the team's most exciting new observations suggests a link between autism and a type of neural stem cell called outer - radial glia (oRGs), discovered by the Kriegstein lab in 2010.
The stem cell closely resembles the radial glial cell in structure and behavior and, like the radial glia, has radial fibers which newborn neurons migrate along up to the neocortex.
They identified gene expression profiles typical of different types of neurons, newborn neural progenitors and radial glia, as well as molecular markers differentiating oRGs and vRGs, which allowed the researchers to isolate these cells for further study.
Radial glia are -LSB-...]
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