Notch signaling is essential for
radial glia stem cell proliferation and a determinant of neuronal number in the mammalian cortex.
An image of tissue that's grown in a dish shows
radial glia stem cells that are red, neurons in blue and the AXL receptor in green.
Not exact matches
One of the team's most exciting new observations suggests a link between autism and a type of neural
stem cell called outer -
radial glia (oRGs), discovered by the Kriegstein lab in 2010.
oRG
stem cells are extremely rare in mice, but common in primates, and look and behave quite differently from familiar ventricular
radial glia.
The
stem cell closely resembles the
radial glial cell in structure and behavior and, like the
radial glia, has
radial fibers which newborn neurons migrate along up to the neocortex.
In 2010, Kriegstein's lab discovered a new type of neural
stem cell in the human brain, which they dubbed outer
radial glia (oRGs) because these cells reside farther away from the nurturing ventricles, in an outer layer of the subventricular zone (oSVZ).