Treating patients with high - dose
radiotherapy after chemotherapy and surgery for malignant pleural mesothelioma does not achieve improvements in local relapse and overall survival, according to data from a prospective randomized phase II trial presented at ESMO 2014 Congress in Madrid.
Not exact matches
The targeted
radiotherapy shrank tumors for 71 % of patients who had already failed standard
chemotherapy, but these results came from a small trial that started with 30 patients and then added another 20
after positive data started rolling in.
Approximately one year
after successful treatment with cytotoxic
chemotherapy and
radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further
chemotherapy.
Cancer stem cells, a type of self - renewing cell found in tumors, are of particular interest because they are the main cell type responsible for tumor progression and for resistance to
chemotherapy and
radiotherapy, and therefore a major cause of tumor recurrence
after treatment.
At Colchester General Hospital, the researchers looked at MR scans taken both before treatment and six weeks
after the patients had completed
chemotherapy and
radiotherapy, and found that the patients whose tumors were less heterogeneous — ie more uniform — in terms of texture parameters six weeks
after treatment were more likely to survive longer.
Appearing in Lancet Oncology, long term results of EORTC trial 22921 with 10.4 years median follow - up show that 5 - FU (fluorouracil) based adjuvant
chemotherapy after preoperative (chemo)-
radiotherapy for patients with cT3 - resectable T4 M0 rectal cancer does not improve survival or disease - free survival.
After the neo-adjuvant
chemotherapy, the patients were then given accelerated
radiotherapy.
The team at Barts Cancer Institute, part of Queen Mary University of London, have found that a molecule, called focal adhesion kinase (FAK), signals the body to repair itself
after chemotherapy or
radiotherapy, which kill cancer cells by damaging DNA.
«Mesothelioma remains a difficult disease to find better treatment options for, so we asked whether high - dose hemithoracic
radiotherapy would decrease the rate or delay the time of local recurrence
after chemotherapy and radical surgery,» says lead author Prof Rolf A. Stahel, from the Clinic and Policlinic for Oncology, at the University Hospital Zurich, Switzerland, and current President of the European Society for Medical Oncology.
At Colchester General Hospital, the researchers looked at MR scans taken both before treatment and six weeks
after the patients had completed
chemotherapy and
radiotherapy, and found that the patients whose tumours were less heterogeneous — ie more uniform - in terms of texture parameters six weeks
after treatment were more likely to survive longer.
Olaparib is a PARP inhibitor, which is already used to treat certain ovarian cancer patients and prevents damaged cancer cells from repairing themselves
after chemotherapy or
radiotherapy.
After a year of treatment, which involved a partial mastectomy to remove a malignant tumor, followed by eight months of
radiotherapy and
chemotherapy, the pop star was given the all clear in November 2006.