Sentences with word «radiotracer»

A pioneer in the diagnostic uses of radiation and the development and testing of radiotracers in the early days of nuclear medicine, Robert N. Beck, professor emeritus in the Department of Radiology at the University of Chicago, died at the University of Chicago Medical Center on August 6, 2008, from myelodysplasia, a form of leukemia.

The team then used a simple radiation detector to track the movement of radiotracers into the plant's shoots and leaves.

Now, using a novel PET radiotracer called Neuroflux, a team of researchers from the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) and the MassGeneral Institute of Neurodegenerative Disease has found a way to quantify olfactory sensory neurons and thus improve measurements of olfactory health.

Now, in a first - in - human study, British researchers have provided a possible solution using Cerenkov luminescence imaging (CLI), which combines optical and molecular imaging by detecting light emitted by the PET radiotracer F -18-fluorodeoxyglucose (F -18-FDG).

«Novel radiotracer measures olfactory neurons in animal models: Tracking deterioration in sense of smell could provide early diagnosis of neurodegenerative disease.»

Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites.»

«New radiotracer helps avoid neck dissection in patients with early head and neck cancer.»

«Neuroflux is the first radiotracer to specifically target the adult - regenerative olfactory sensory neurons that reside within the nasal cavity,» said Genevieve Van de Bittner, PhD, an investigator in the Martinos Center and lead author of the Journal of Clinical Investigation paper.

Dr. Kuo - Shyan Lin's laboratory is developing radiotracers for applications in oncology and neuroscience.

For this research, a total of 28 subjects were imaged with a variety of imaging modalities, including standard imaging with computed tomography, magnetic resonance imaging and molecular bone scan (SI); PET with a common radiotracer called fluorodeoxyglucose (FDG - PET); and PET with computed tomography and the agent Zr - 89 IAB2M (IAB2M PET / CT) assessed in escalated doses.

The study shows the first direct evidence of BNF by tracking the presence of a nitrogen radiotracer as it was absorbed first by the bacteria and then moved through the plant.

Measuring tau deposits using the novel radiotracer F -18-AV-1451 (F -18-T807), in conjunction with C -11-PiB to measure amyloid plaques and F -18-FDG to measure regional neurodegeneration, offers new insight into the neurodegenerative characteristics of Alzheimer's disease and shows that tau pathology may be an instrumental target for disease - modifying strategies.

«Brookhaven's radiotracer tools offer a singular window into plant metabolism and plant - microbe interactions.»

The PET radiotracer C - 11 PBR28 was administered to eight healthy men around the age of 25, give or take six years, followed by two separate PET scans on the same day for each subject before and after injection with LPS.

Dr James Rudd, a cardiologist and researcher from the Department of Cardiovascular Medicine at the University of Cambridge adds: «Sodium fluoride is a simple and inexpensive radiotracer that should revolutionise our ability to detect dangerous calcium in the arteries of the heart and brain.

3 and GRPR targeting PET radiotracer 68Ga - BBN - RGD» include Jingjing Zhang, Fang Li, Shaobo Yan, Li Huo, Libo Chen, Xinrong Fan, Weigang Yan, Zhiyuan Li and Zhaohui Zhu, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Gang Niu, Lixin Lang, Xuefeng Yan, and Xiaoyuan Chen, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, Maryland.

The development of radiotracers like this could radically change drug development, especially for neurological disorders, which are notoriously difficult to study in animal models.

Measuring tau deposits using the novel radiotracer 18F - AV - 1451 (18F - T807), in conjunction with 11C - PiB to measure amyloid plaques and 18F - FDG to measure regional neurodegeneration, offers new insight into the neurodegenerative characteristics of Alzheimer's disease and shows that tau pathology may be an instrumental target for disease - modifying strategies.

San Diego, Calif. (Embargoed until 1:15 PM on Wednesday, June 15)-- Positron emission tomography (PET) with three different radiotracers can now measure amyloid plaques, tau tangles and metabolic activity in the brains of living Alzheimer's patients.

«This technology allows us to obtain in - depth knowledge of molecular imaging techniques, how to optimize them, and how to leverage data with statistical analysis while advancing new radiotracers and contrast agents for the imaging and treatment of a range of diseases,» said Zhen Liu, PhD candidate and lead author of the study from the department of nuclear medicine at Technical University Munich, in Munich, Germany.

The researchers now plan to start a study in the EU in which patients will undergo SN mapping (lymphoscintigraphy) after injection of both types of radiotracers.

«This result is better than bone scanning with MDP,» Chen notes, referring to the most common radiotracer used today.

The scientists used Brookhaven's Cyclotron — a small accelerator dedicated to isotope production — to produce the nitrogen radiotracer, which was then introduced to the soil in a stream of air.

He explains, «To our knowledge, this is the first radiotracer to interrogate the activity of PATs, which play a role as multi-purpose carriers with distinct roles in different cells.

The study indicates that the new agent — a PET radiotracer — is both safe and effective.

The novel radiotracer, called Zr - 89 Df - IAB2M (IAB2M), is imaged faster than the full antibody (J591) that targets PSMA and has been shown to be safe for patients.

Xiaoyuan Chen, Ph.D., Chief of the Laboratory of Molecular Imaging and Nanomedicine at NIBIB, and his team attempted to solve this problem by developing a radiotracer that could identify prostate cancer at all stages.

The current method of identifying bone lesions is to use the radiotracer MDP with a SPECT scanner.

«New radiotracer could make diagnosing prostate cancer faster and easier.»

Researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have developed a new radiotracer to diagnose prostate cancer and conducted a successful Phase I clinical trial.

Radiotracers are made up of carrier molecules that are bonded tightly to a radioactive atom.

Our current multi-centre pivotal study has shown that in many patients, by using a radiotracer with a novel receptor - based mechanism, the SN can be reliably identified and removed for biopsy without having to undertake more extensive surgery.

«With further validation, this radiotracer could also potentially be used to perform targeted biopsies for precise tissue analysis, which could lead to earlier, more appropriate treatment for prostate cancer patients.»

The radiotracer combines a small amount of the radioactive material zirconium - 89 with a fragment of an antibody called a minibody.

This illustration shows the absorption of the Nitrogen - 13 radiotracer, which is later detected inside the shoots and leaves.

«This radiotracer only has a half - life of 10 minutes, meaning it becomes inactive and undetectable very quickly,» Ferrieri said.

LPS stimulates the immune system and is accompanied by a radiotracer called carbon - 11 PBR28 (C - 11 PBR28).

For this study, a tumor cell line was transplanted into a rat and imaged with each of the following: conventional MRI, the radiotracer carbon - 13 (C - 13) pyruvate and hyperpolarized MRI at a resolution of 2.5 mm, Medipix positron detector, luminescence sensor and a fluorescence microscope.

MBI uses small, semiconductor - based gamma cameras to image the breast following injection of a radiotracer that tumors absorb avidly.

For the JCI study, the team applied the radiotracer to monitor olfactory sensory neuron population dynamics in a rodent model, using PET to measure its uptake across the animals» lifespan, including during age - related neurodegeneration.

The researchers have obtained FDA approval to begin testing the radiotracer in humans and scanned about a dozen volunteers thus far.

This confirmed that the radiotracer accumulates in areas of active, unstable calcification whilst avoiding surrounding tissue.

For this study, 10 subjects with Alzheimer's underwent PET following the injection of three radiotracers: fluorine - 18 fluorodeoxyglucose (F - 18 FDG), which images regional metabolic activity; carbon - 11 Pittsburgh compound B (C - 11 PiB), which has an affinity for amyloid plaques; and F - 18 AV - 1451, an emerging imaging agent that binds to tau in the brain.

In a recent test of the system, the researchers evaluated the spatial resolution and contrast - to - noise ratio in images of a «breast phantom,» a plastic mockup of a breast with four beads inside simulating cancer tumors of varying diameter that are marked with a radiotracer.