Researchers in Canada, the United States, France, Austria, Australia, Poland, New Zealand and Estonia conducted a study (FREEDOM) to evaluate changes over time in radius bone mineral density and wrist fracture incidence.
During the original trial, daily calcium and vitamin D alone was associated with a progressive and significant loss of bonemineral density at the 1/3 radius -LRB--1.2 %).
In one of the first studies of its kind to use a special scanning technique, researchers found that people with a history of heart disease had substantially lower cortical volumetric bonemineral density in their wrist bone (the distal radius) than those without.