Sentences with phrase «raft domains»

That's why no one could observe raft domains in real cells before.

Gangliosides are lipid molecules that were proposed to play key roles in numerous biological processes, including the formation of raft domains, the entry of toxins into cells and chemical signal reception.

«The existence of special membrane domains, called raft domains, has been assumed for over 25 years, but was never found to actually occur in living cells,» said Dr. Naoko Komura of Gifu University, the first author of the paper.

Scientists from Japan, India and the U.S. have observed raft domains — active sections of the cell membrane with special groups of molecules — in live cells for the first time.

«Our findings established the concept of dynamic raft domains: their constituent molecules assemble to form raft domains, do their jobs within several tens of milliseconds, and then move away for the next assembly to perform the next task.»

Now, researchers can begin to investigate further how toxins, bacteria and viruses invade cells through these raft domains.

However, it was not clear how SMs interacted with other molecules of raft domains, mainly because of the lack of a suitable synthetic probe of SM.

Further analysis revealed the dynamic behavior of SMs as they rapidly associated and dissociated from raft domains involving different formations of CD59 and with the plasma membrane.

Top: Typical image sequences (every 33 milliseconds) of a raft domain undergoing signaling (green) and a sphingomyelin analog (red).

The sphingomyelin analog molecule was associated with a signaling raft domain from frame 4 to 9 (orange arrows).

Not exact matches

Transmembrane domains 1 and 2 of the latent membrane protein 1 of Epstein - Barr virus contain a lipid raft targeting signal and play a critical role in cytostasis.

Accumulation of raft lipids in T - cell plasma membrane domains engaged in TCR signalling.

The contribution of extracellular determinants to the construction of endocytic pits has received much less attention, depite the fact that (glyco) sphingolipids are exoplasmic leaflet fabric of membrane domains, termed rafts, whose contributions to predominantly clathrin - independent internalization processes is well recognized.