Sentences with phrase «randomised trials study»

Use of heparins in patients with cancer: individual participant data meta - analysis of randomised trials study protocol

Not exact matches

The sample size was small, and the researchers stated that the research findings indicate the need for a randomised control trial (RCT) as RCT's are widely recognised as the best study design.

The 12 week clinical study from the US of 303 participants is the first prospective, randomised clinical trial to directly compare the effects of water and diet beverages on weight loss within a behavioural weight loss program.

Meta - analyses of cohort studies for the association between dairy and milk intake in relation to mortality11 and fractures12 13 have displayed no clear pattern of risk, and evidence from randomised trials are lacking.

Dietary sugars and body weight: systematic review and meta - analyses of randomised controlled trials and cohort studies

He established and leads the innovative China Salt Substitute and Stroke Study (SSaSS), a 21,000 - person cluster randomised trial in rural China investigating whether salt reduction reduces the risk of stroke.

And Dr Jonathan Scourfield at the Cardiff School of Social Sciences is undertaking a feasibility study for a randomised controlled trial of a training intervention to improve the engagement of fathers in the child protection system.

As it has been shown that conducting a randomised controlled trial is not possible, the best evidence about the safety of home birth can only come from good quality, routine registrations such as the one we used in our study.

A randomised controlled trial would be the best way to tackle selection bias of mothers who plan a home birth, but a randomised controlled trial in North America is unfeasible given that even in Britain, where home birth has been an incorporated part of the healthcare system for some time, and where cooperation is more feasible, a pilot study failed.31 Prospective cohort studies remain the most comprehensive instruments available.

The DAME study was the first randomised controlled trial to test the practice of antenatal hand expression of colostrum.

The study was a multicentre, randomised control trial which involved six hospitals in Victoria, Australia.

The Diabetes and Antenatal Milk Expressing (DAME) study is a randomised controlled trial carried out by a team of researchers in Australia.

COMET Study Group UK, «Effect of Low - Dose Mobile versus Traditional Epidural Techniques on Mode of Delivery: A Randomised Controlled Trial,» Lancet 358, no. 9275 (2001): 19 — 23.

This updated review includes 100 trials involving more than 83,246 mother - infant pairs of which 73 studies contribute data (58 individually - randomised trials and 15 cluster - randomised trials).

In the absence of a randomised trial, observational studies are welcome, and this week's BMJ...

The objective of the current study was to systematically review randomised controlled trials of parenting programmes for the treatment of children with conduct problems.

Randomised and non-randomised trials; and observational studies evaluating the provision of skilled birth attendance and emergency obstetric care

Out of the 10 included studies (a total of 5787 women, including 512 women interviewed as part of a cluster randomised trial), only two studies gathered data for multiples separately and were able to provide us with the data (Paul 2012; Reeder 2014, a total of 42 women with multiples).

This study was a feasibility study for a proposed randomised trial.

Trials recruited 5787 women (this included 512 women interviewed as part of a cluster randomised trial); of these, data were available from two studies for 42 women with twins or higher order multiples.

We searched for randomised controlled trials on 30 June 2016 and 1 July 2016 and found 10 studies (23 reports) to include in our review.

Given the heterogeneity in the choice of outcome measures routinely collected and reported in randomised evaluations of models of maternity care, a core (minimum) data set, such as that by Devane 2007, and a validated measure of maternal quality of life and well being would be useful not only within multi-centre trials and for comparisons between trials, but might also be a significant step in facilitating useful meta - analyses of similar studies.

24 randomised and 2 non-randomised trials of intervention packages, including mainly: building community - support or women's groups (9 studies), community mobilisation and antenatal and postnatal home visitation (7 studies), community mobilisation and home - based neonatal treatment (1 study), training traditional birth attendants who made antenatal and intrapartum home visits (2 studies), home - based neonatal care and treatment (2 studies), and education of mothers and antenatal and postnatal visitation (2 studies)

The updated Cochrane Review concludes that there is no strong evidence from experimental studies (randomised trials) to favour either planned hospital birth or planned home birth for low - risk pregnant women.

Although professional lactation support can improve the duration of overall breast feeding, its effect in improving exclusive breast feeding is unclear.11 18 22 Thus far, studies that report improvement of rates of exclusive breastfeeding have involved mainly community based peer counselling strategies.23 24 25 Even then, a randomised trial in the UK recently cast doubt on the efficacy of this approach.26 There are current recommendations from NICE for the UK - wide implementation of the baby friendly initiative.4 5 6 The 2006 NICE costing report on routine postnatal care of women and their babies estimates that efforts to improve rates of breast feeding will result in substantial cost savings for the NHS.6

A randomised trial in Brazil that compared a hospital based protocol (similar to the baby friendly hospital initiative) with another incorporating intensive home visits, however, found that while the protocol achieved high rates of exclusive breast feeding in hospital, the rates fell rapidly thereafter.27 These findings were confirmed in the UK by the millennium cohort study, 5 and the authors recommended that the baby friendly hospital initiative as a strategy for promotion of breast feeding should be reassessed and that other strategies are required to support mothers in the UK to breast feed for the recommended duration.5 27 Although combined antenatal education and postnatal support is ideal, this may be limited by economic or time resources.

Ghana's Ensure Mothers and Babies Regular Access to Care (EMBRACE) programme: study protocol for a cluster - randomised controlled trial

Given the heterogeneity in the choice of outcome measures routinely collected and reported in randomised evaluations of models of maternity care, a core (minimum) dataset, such as that by Devane 2007, and a validated measure of maternal quality of life and wellbeing would be useful not only within multi-centre trials and for comparisons between trials, but might also be a significant step in facilitating useful meta - analyses of similar studies.

The M@NGO Study (Midwives at New Group practice Options): A randomised controlled trial of caseload midwifery care.

The study presents a randomised trial of nurse - midwifery prenatal care to reduce low birthweight: intrapartum and postpartum care are not part of the intervention.

A formative study using participatory action research design will first be conducted, followed by a cluster - randomised trial utilising both qualitative and quantitative data collection methods.

Only 10 (23 %) of these additional recommendations were based on evidence from randomised controlled trials, and seven (16 %) were based on evidence from phase III studies.

However, these studies are not randomised controlled trials — the gold standard — in which people are randomly assigned placebos or drugs.

Previous studies have suggested that various forms of meditation can improve attention and reduce stress, but there have been few randomised controlled trials — the best way of testing a treatment's effectiveness.

The author studied the effect of vitamin E on the risk of pneumonia in a large randomised trial (Alpha - Tocopherol Beta - Carotene Cancer Prevention Study — ATBC) conducted in Finland between 1985 and 1993.

CT - P13 has previously demonstrated pharmacokinetic (PK) equivalence to INX in the PLANETAS trial, a randomised double - blind, parallel group study of 250 patients with AS, and was recently approved by the European Medicines Agency.

Commenting on the trial, Dr Alice Shaw, director of thoracic oncology at the Massachusetts General Hospital Cancer Centre in Boston, US, said: «This is the first randomised study to examine how a second generation ALK inhibitor compares to standard second line chemotherapy in ALK positive patients who failed the standard first line therapy, which currently is crizotinib.»

A comparison of the surgical removal of rectal tumours by a laparoscopically - assisted procedure and open surgery reveals that the case for routine use of laparoscopic procedures has not yet been established, according to a randomised control - trial study published in the Journal of the American Medical Association (JAMA).

We intend to build on this work with larger studies, and ultimately test this idea in a randomised trial».

For this study, Kable and his colleagues recruited 128 young healthy adults for a randomised controlled trial.

The new study, funded by the National Institute for Health Research, and published in The Lancet Respiratory Medicine, collated and analysed the individual data from 955 participants in seven randomised controlled trials, which tested the use of vitamin D supplements.

So researchers in the UK and US analysed the results of over 90 studies (a mix of randomised trials and cohort studies) of prenatal iron use and prenatal anemia, involving nearly two million women.

The Maternal Vitamin D Osteoporosis Study (MAVIDOS) is the first randomised, placebo - controlled trial designed to measure the impact of pregnancy vitamin D supplementation on the bone health of babies using bone density scanning.

Investigator Dr Noor Danhof from the AMC Centre for Reproductive Medicine in Amsterdam says the results of the study, a large randomised trial performed in the Netherlands, now make this «least expensive and least invasive stimulation agent» the drug of choice in IUI.

The gold standard in clinical trials is a randomised, placebo - controlled study.

The IVV study is the first long - term, prospective randomised trial comparing the effect of red and white wine on markers of atherosclerosis.

The study was prompted by conjecture about the causative relationship between periodontal (gum) disease and atherosclerotic vascular disease and is among the first using a randomised trial to investigate a periodontal intervention on atherosclerotic disease.

Adjunctive dexamethasone for the treatment of HIV - infected adults with tuberculous meningitis (ACT HIV): Study protocol for a randomised controlled trial

The latest data, the result of the largest long - term follow - up study of autism treatment yet undertaken, is from a randomised controlled trial by three UK research groups and published in The Lancet.

We also performed subgroup meta - analyses by type of prevention (primary v secondary: in this study, trials involving healthy populations or patients with any specific disease except for cardiovascular disease were classified as primary prevention trials, and trials involving patients with cardiovascular disease were classified as secondary prevention trials), type of supplement by quality and dose (each supplement, vitamins only, antioxidants only, or antioxidants excluding vitamins), type of outcome (cardiovascular death, angina, fatal or non-fatal myocardial infarction, stroke, or transient ischaemic attack), type of outcome in each supplement, type of study design (randomised, double blind, placebo controlled trial v open label, randomised controlled trial), methodological quality (high v low), duration of treatment (< 5 years v ≥ 5 years), funding source (pharmaceutical industry v independent organisation), provider of supplements (pharmaceutical industry v not pharmaceutical industry), type of control (placebo v no placebo), number of participants (≥ 10000 v < 10000), and supplements given singly or in combination with other vitamin or antioxidant supplements by quality.