Fifth, in collaboration with Dr. Julia Babcock (a former graduate student, now professor at the University of Houston), an initial
randomized clinical trial study was performed with very difficult characterologically violent married men.
We performed
a randomized clinical trial study with long - term follow up.
They performed
a randomized clinical trial study with long - term follow up.
Not exact matches
Last year The Ohio State University Wexner Medical Center began
clinical trials on the efficacy of SuperBetter to treat traumatic brain injuries, and the University of Pennsylvania Positive Psychology Center greenlighted a
randomized controlled user
study of the game to treat depression.
Besides
randomized controlled
clinical trials, there are a number of ways researchers can
study how a particular cancer treatment is playing out in the real world: there are retrospective
studies, observational
studies, and even prospective research done using patient registries.
First, the topline numbers: The
study was an observational one rather than a
randomized control
trial, the latter of which is considered to be the «gold standard» of
clinical studies.
At The Fertility Center of Las Vegas, each
clinical trial is designed as a prospective,
randomized study.
The PhD course focuses on various aspects of human (donor) milk, with as main
study a randomized clinical trial towards the effects of human donor milk in very low birth weight infants (the Early Nutrition St
study a
randomized clinical trial towards the effects of human donor milk in very low birth weight infants (the Early Nutrition
StudyStudy).
This
study is a
randomized clinical trial of 125 mother / infant pairs.
This
study is a
randomized clinical trial (RCT) with 50 mother / infant pairs in the intervention arm, 50 in one control group and 25 in a third control group.
In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from
clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational
studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter,
randomized controlled
trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.
Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed
randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1
study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.
The neuroprotective effects of nicotine were
studied in a
randomized clinical trial involving 67 subjects in the early stages of Alzheimer's disease, where memory was slightly impaired but decision - making and other cognitive abilities remained intact.
The REACT (
Randomized Evaluation of an Algorithm for Crohn's Treatment)
study, led by Robarts
Clinical Trials at Western University (London, Canada) provides valuable new insights for community gastroenterologists which should benefit patients.
Since
randomized clinical trials — the gold - standard in research — don't accommodate patients» preferences, Zoellner and her research team used a
study design called a «doubly
randomized preference
trial» to investigate whether giving patients a choice affects their treatment outcomes.
Another problem is that modeling
studies, like this one, are inherently less powerful than other kinds of medical research:
randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control
studies, which compare patients who have a condition with those who do not; or cohort
studies, which determine the risk of contracting a disease by
studying a group of people with similar demographics.
The epidemiological evidence was strong enough that it led to a whole series of
clinical studies and
randomized control
trials with fish oil, says nutritionist Penny M. Kris - Etherton of Pennsylvania State University.
And the Sanofi Pasteur
study was a
randomized, controlled, blinded
trial — the gold standard in
clinical research.
The new
study is a meta - analysis of three
randomized controlled
trials conducted by the Alliance for Clinical Trials in Oncology (formerly Cancer and Leukemia Group B)(CALGB) with support from the NCI, Intergroupe Francophone du Myélome (IFM), and the Gruppo Italiano Malattie Ematologiche dell «Adulto (GI
trials conducted by the Alliance for
Clinical Trials in Oncology (formerly Cancer and Leukemia Group B)(CALGB) with support from the NCI, Intergroupe Francophone du Myélome (IFM), and the Gruppo Italiano Malattie Ematologiche dell «Adulto (GI
Trials in Oncology (formerly Cancer and Leukemia Group B)(CALGB) with support from the NCI, Intergroupe Francophone du Myélome (IFM), and the Gruppo Italiano Malattie Ematologiche dell «Adulto (GIMEMA).
«While
randomized clinical trials are needed to test whether this is a causal relationship, these findings indicate doctors should consider using or re-starting ACEIs and ARBs as first - line blood pressure medications for patients undergoing peritoneal dialysis,» said Jenny I. Shen, MD, an LA BioMed researcher and corresponding author of the
study.
«But as a clinician, if there are
randomized data that would allow us to go from a pilot
study to a phase 3
clinical trial, and if the results are good, then we would have to come back to Francis Collins, and say, «This needs to be exported to other communities and ramped up.»
The determination of each efficacy level was also based on the rigor and quantity of published
studies on the drug class: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I»
studies — well - designed, double - blind,
randomized, placebo - controlled
clinical trials.
«Not only do we believe that high - quality,
randomized clinical trials are necessary to determine the safety of the Lariat device for off - label procedures, but our analysis raises broader issues with the FDA 510 (k) clearance protocol for medical devices,» said
study senior author Jay Giri, MD, MPH, assistant professor in the Cardiovascular Medicine Division at Penn. «We believe there needs to be a method for reassessing the safety of a device that has been cleared for one use but is being frequently used for a different purpose in real - world practice.»
The QUARISMA (QUAlity of Care, Obstetrics RISk MAnagement and Mode of Delivery in Quebec)
study is a cluster -
randomized clinical trial that took place in 32 hospitals in Quebec between 2008 and 2012.
The new six - year
study, «Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18 - month
randomized clinical trial,» involved 54 adults and was led by Shaun Eack, Ph.D., M.S.W., Pitt's David E. Epperson Professor of Social Work and Psychiatry, and Nancy Minshew, M.D., Pitt professor of psychiatry and neurology.
Using simple statistics, without data about published research, Ioannidis argued that the results of large,
randomized clinical trials — the gold standard of human research — were likely to be wrong 15 percent of the time and smaller, less rigorous
studies are likely to fare even worse.
Motivated by their previous finding of the presence of P - glycoprotein overexpression in the nasal lining of patients with CRS with nasal polyps, the
study authors conducted a
randomized, double - blind, placebo - controlled
clinical trial studying the use of low - dose Verapamil in 18 patients with CRS with nasal polyps.
Our
study is not a definitive
randomized clinical trial, but it does suggest that we are over-testing and over-treating these patients.»
Julia Lewis, MD (Vanderbilt University School of Medicine) and her colleagues in the Collaborative
Study Group conducted a 441 - patient
randomized clinical trial to test the potential of a compound called ferric citrate to bind phosphorus, increase iron stores, and reduce the usage of IV iron and ESAs.
One 2008
study, for instance, analyzed 16 papers investigating publication bias in
randomized clinical trials and found clear indications of selective publication.
«The finding from this observational
study that women who underwent menopause at a later age and used oral hormone therapy had greater hearing loss was unexpected but should lead to more testing in a
randomized,
clinical trial,» says Dr. JoAnn Pinkerton, NAMS executive director.
Randomized clinical trials have shown, for instance, that screening for breast cancer saves lives, but similar
studies for the PSA test haven't been completed.
The resveratrol
clinical trial was a
randomized, phase II, placebo - controlled, double blind
study in patients with mild to moderate dementia due to Alzheimer's disease.
The
study analyzed data from three
randomized, controlled
clinical trials conducted between 2001 and 2015 called INFANT, PEAK and MIST that included 736 children.
The
study, published in the July issue of the journal Epidemiology, offers benefits over typically used
randomized clinical trials, as such
studies are often too small to identify rare side effects or may be performed in a group of patients who do not take other types of medications or have other conditions that could skew the drug's effect in a broader group following approval.
This
study was presented as the Late - Breaking
Clinical Trial (Abstract 49403): The Surgical Treatment of Moderate Ischemic Mitral Regurgitation: A
Randomized Clinical Trial From The Cardiothoracic Surgical
Trials Network.
This
study was presented at the Featured
Clinical Research Session I: Two - year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation: A
Randomized Clinical Trial from The Cardiothoracic Surgical Trials Network The Moderate Ischemic Mitral Regurgitation trial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health Rese
Trial from The Cardiothoracic Surgical
Trials Network The Moderate Ischemic Mitral Regurgitation
trial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health Rese
trial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health Research.
Called the high - dimensional propensity score algorithm (hd - PS), it is a tool for improving not
randomized clinical trials but broader observational
studies, in which researchers watch a large pool of participants and look for correlations — like the fact that wine drinkers live longer than other drinkers.
By
studying this population over time in a
randomized clinical trial, the research team was able to eliminate many confounding variables.
A search of the medical literature identified 122
randomized clinical trials (RCTs) and 1 cohort
study (totaling 22,803 participants) that met criteria for inclusion in the analysis.
The
study, a retrospective survival analysis, included 229 patients who participated in two
randomized, controlled
clinical trials focused on relief of constipation for patients receiving palliative care for various types of late - stage cancer and other terminal diseases.
Our results suggest the need for future
studies involving long - term ambulatory cardiac monitoring to better delineate the risk associated with transient vs persistent perioperative AF, as well as
randomized clinical trials to determine optimal strategies for antithrombotic therapy in patients with perioperative AF and a significant burden of other risk factors for stroke,» the authors write.
Earlier observational
studies had shown a similar impact of ARVs reducing sexual transmission in heterosexual couples, but this was the first to demonstrate the prevention power of the drugs in a
randomized, controlled
clinical trial.
Study participants (n = 146; 101 males, 45 females) were enrolled in a 16 - week
randomized clinical trial comparing naltrexone with placebo treatment.
Limitations of the
study include losing about half of the participants to long - term follow - up during the transition from a
randomized clinical trial to a cohort
study.
In this
study, to our knowledge the largest
randomized clinical trial of robotic - assisted laparoscopic surgery for patients with rectal adenocarcinoma suitable for curative resection, there were no statistically significant differences in the rates of conversion to open laparotomy for robotic - assisted laparoscopic surgery compared with conventional laparoscopic surgery (8.1 % vs 12.2 %, respectively), and there were no statistically significant differences in CRM +, complication rates, or quality of life at 6 months.
This
study has been published in the Neuroimage journal and is part of the ActiveBrains project, which is a
randomized clinical trial involving more than 100 overweight / obese children led by Francisco B. Ortega.
In the $ 1.47 million, four - year grant called â $ œBiomarkers of Ischemic Outcomes in Intracranial Stenosisâ $ (BIOSIS), Emory researchers are analyzing blood samples from 451 patients from around the country who were enrolled in a
study known as SAMMPRIS (Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis), the first
randomized, multicenter
clinical trial designed to test whether stenting intracranial arteries would prevent recurrent stroke.
The authors of the current
study conducted a
randomized, multicenter,
clinical trial that included 1,000 Chinese women with PCOS at 21 sites in China.
One of the most comprehensive reviews on the effects of mindfulness meditation on immune parameters was recently conducted across 20
randomized clinical trials.23 Three of these
studies found decreased NF - KB and no strong evidence for changes in interleukin inflammatory markers (interleukin - 6) or TNF - α, but some evidence for a decrease in CRP and increases in telomerase.