Sentences with phrase «randomized research trial»

Not exact matches

Besides randomized controlled clinical trials, there are a number of ways researchers can study how a particular cancer treatment is playing out in the real world: there are retrospective studies, observational studies, and even prospective research done using patient registries.

The research team conducted a randomized blinded trial of intercessory prayer added to normal cancer treatment with participants agreeing to complete quality of life (QOL) and spiritual well - being scales at baseline and 6 months later.

Through a randomized trial of more than 3,000 first - time mothers, the research team out of the University of Birmingham in England studied the effects of two laboring positions.

His primary research interests since 1996 have been in the design and conduct of a number of randomized trials in clinical obstetrics and perinatology.

It certainly is ironic that, while the gold standard of medical research is the randomized controlled trial, which generally looks at the risks and benefits of an intervention on a population level, it is individual women who have to make the decisions — and individual women may not always find these kind of data helpful.

Going a step further, even if the Succinic Acid can be absorbed through your child's skin without causing skin irritation, there is no research to support the claims that it acts as a pain reliever — plenty of internet anecdotes from believing parents, yes, but no randomized controlled trials.

In the evidence pyramid a randomized controlled trial is the highest form of primary research, and a synthesis of studies provides the best evidence.

Be sure to read a more recent post from October 2014 about two randomized controlled trials that clarified several of the issues discussed in the post above: New Research on Gluten Introduction to Infants and Risk of Celiac Disease

Research shows that families typically receive roughly half of the number of home visits expected.16, 17 For example, across three randomized controlled trials conducted of Nurse Family Partnership, average dosage of visits ranged from 45 to 62 percent.18 Research also shows that many, perhaps most, families enrolled in home visiting programs drop out before their eligibility ends.16, 19,20 Some home visiting studies have varied the dosage that families were offered and found that fewer home visits produced outcomes similar to higher levels of exposure.21

Other difficulties when conducting or evaluating research in this area include ensuring the equivalency of the control and experimental groups in randomized controlled trials (RCTs), 10 controlling for participant attrition (which may affect the validity of findings by reducing group equivalence) and missed visits (which may affect validity by reducing program intensity), 11 documenting that the program was fully and accurately implemented, and determining whether the program's theory of change logically connects program activities with intended outcomes.

Although randomized controlled trials are considered the «gold standard» of research, how could one ethically assign women to birth at home or hospital?

In 2011, the Cochrane Collaboration, a nonprofit independent research organization, analyzed the results of 15 randomized clinical trials that had evaluated whether omega - 3 — fortified infant formulas, fed to full - term babies for up to the first year of life, provide developmental benefits compared with nonfortified infant formulas.

While the gold standard of clinical research is the double - blind, placebo - controlled, randomized clinical trial, it is impossible to blind a mother to whether she is giving birth at home or in a hospital, and most mothers are unwilling to be randomized to a home birth or hospital birth.

Another research gap is that there were no published randomized trials evaluating interventions targeting Native Americans or Asians.

To clarify the current evidence, additional research using the rigorous scientific methodology of the randomized clinical trial will be necessary.

Sarah, while it's been a while since I've read that Cochrane review, my remembrance is that you are talking about «randomized» trials... the gold standard in research.

Both papers were randomized control trials (RCTs), the gold standard in political research.

Researchers at St. Michael's Hospital undertook a systematic review and meta - analysis of all of the available evidence from randomized controlled trials, the gold standard of research design.

«In the case of pharmaceuticals, the onus is on the pharmaceutical company to do the research with toxicity testing, randomized control trials and post-exposure observational studies,» Conry said.

The team, working in partnership with the Kenya Medical Research Institute (KEMRI), the U.S. Centers for Disease Control and Prevention (CDC), and other colleagues from around the world, carried out a randomized controlled trial in western Kenya.

The use of registries as an adjunct or alternative to randomized controlled trials in medical research, coinciding with the rapid growth of social networking, has produced a burgeoning phenomenon - online patient - generated health registries.

While randomized clinical trials are the gold standard of clinical research, such trials are not feasible for testing anesthesia technique in joint replacement surgeries, because the low incidence outcomes would require a huge number of patients.

He identified 193 Phase III randomized trials — the gold standard in clinical research — for analysis.

The research, entitled «Adjunctive yoga v. health education for persistent major depression: a randomized controlled trial,» has been published in Psychological Medicine.

«Our main conclusion is that even a totally unbiased, perfectly randomized, reliably blinded, and faithfully executed clinical trial may still generate false and irreproducible results,» he writes in a recent issue of BMC Medical Research Methodology.

Since randomized clinical trials — the gold - standard in research — don't accommodate patients» preferences, Zoellner and her research team used a study design called a «doubly randomized preference trial» to investigate whether giving patients a choice affects their treatment outcomes.

Another problem is that modeling studies, like this one, are inherently less powerful than other kinds of medical research: randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control studies, which compare patients who have a condition with those who do not; or cohort studies, which determine the risk of contracting a disease by studying a group of people with similar demographics.

In a randomized, controlled clinical trial — the first of its kind — a multi-institution research team reports that daptomycin, part of a new class of antibiotics currently approved only for use in adults, is effective and well - tolerated in children.

And the Sanofi Pasteur study was a randomized, controlled, blinded trial — the gold standard in clinical research.

The small trial was not randomized, double - blinded or placebo - controlled — the combination of which is considered the gold standard in clinical research.

«Our research is exciting as it represents the only double - blind, randomized clinical trial with this large of a sample size, and a mid-term follow - up rate of five years,» noted Mohtadi.

To test the potential benefit and safety of targeted hypothermia in donors on delayed organ function rates in the recipients of their kidneys, Niemann and his research team conducted a randomized controlled trial in two large organ donation service areas from March 2012 to October 2013.

The research team used data from the recently published EORTC 22991 trial to study men with intermediate - risk prostate cancer randomized to either radiation therapy or radiation therapy and 6 months hormone therapy.

The paper stresses that more research, especially randomized controlled trials with long - term follow - up, would be needed to reach a definite conclusion on the risk of TRT on cardiovascular outcomes.

Using simple statistics, without data about published research, Ioannidis argued that the results of large, randomized clinical trials — the gold standard of human research — were likely to be wrong 15 percent of the time and smaller, less rigorous studies are likely to fare even worse.

The next research step should be a controlled randomized trial of how bipolar patients taking supplements fare compared with those taking a placebo.

Kelly E. Dunn, Ph.D., of the Johns Hopkins University School of Medicine, Baltimore, and coauthors conducted a randomized clinical trial in a residential research setting with 103 patients, mostly men, with opioid use disorder.

This is the basic outline of a randomized control clinical trial — the gold standard of medical research and the basis of most of the medical facts we hear from doctors and read in magazines like this one.

The study was the first ASD research to use a sequential multiple assignment randomized trial, or SMART, design.

The research team conducted a randomized controlled trial in 14 health centers in New York City, and compared the birth outcomes of women who received CenteringPregnancy Plus group prenatal care to those who received traditional individual care.

«Taking a break from dieting may improve weight loss: Research showed in a randomized controlled trial, that taking a 2 - week break during dieting may improve weight loss.»

In 2002 the Department of Education established the Institute of Education Sciences (IES) to encourage researchers to pursue what was described as «scientifically valid research,» especially randomized controlled trials, which advocates of IES considered the gold standard.

This study was presented at the Featured Clinical Research Session I: Two - year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation: A Randomized Clinical Trial from The Cardiothoracic Surgical Trials Network The Moderate Ischemic Mitral Regurgitation trial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health ReseTrial from The Cardiothoracic Surgical Trials Network The Moderate Ischemic Mitral Regurgitation trial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health Resetrial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health Research.

A large randomized controlled trial of ischemic postconditioning in patients who had experienced the deadliest form of heart attack — ST - segment elevation myocardial infarction (STEMI)-- failed to show that this procedure significantly reduces death from any cause or hospitalization for heart failure, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.

By studying this population over time in a randomized clinical trial, the research team was able to eliminate many confounding variables.

The research, which appears online Aug. 1 in the journal Annals of Neurology, is the first study from a double - blind controlled randomized trial of an exon - skipping agent to provide conclusive proof based on the standard six - minute walk test used to measure muscle function in patients with Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy in children.

The research presented is part of, «A Randomized Trial of Induction Versus Expectant Management,» more commonly referred to as the ARRIVE Trial, which was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

The early findings are so promising that the researchers have been awarded a grant from the Australian Research Council, in partnership with Villa Maria Catholic Homes, to follow up on the study with a large randomized control trial.

«PROBIT, the largest randomized trial ever carried out in the area of human lactation, continues to yield scientifically and clinically important information more than two decades after its inception,» says Dr. Michael Kramer, from McGill's Faculty of Medicine and the Research Institute of the McGill University Health Centre (RI - MUHC), the Principal Investigator on the PROBIT study.

John DeLuca, PhD, VP of Research & Training chairs Workshop 6: Cognitive Rehabilitation in MS. Dr. DeLuca discusses assessment of cognitive problems and introduces common evidence - based techniques for improving cognitive functioning in persons with MS. Nancy Chiaravalloti, PhD, director of Neuropsychology & Neuroscience Research, presents two recent double - blind, placebo - controlled, randomized control trials of behavioral interventions designed to specifically improve learning and memory in persons with MS. Yael Goverover, PhD, OT, focuses on techniques to improve learning and memory, with a specific emphasis on improving everyday functional activity.