A randomized study by MDRC found that students in academies were less likely to drop out, had significantly better attendance, and had a 20 percent higher college - application rate than their peers not in academies.
A recent
randomized study by Duke University researchers in 2010 involving 144 overweight, unmedicated patients showed that the diet alone could reduce systolic blood pressure (the top blood pressure number) by 11 points and diastolic blood pressure by 7 points.
Not exact matches
For the same reason, it is not easy to prove treatment efficacy
by means of controlled,
randomized studies, the «gold standard» for evaluating new therapies.
He points to research
by a Stanford University researcher, Allan K. Mishra, who has
studied PRP for years, whose in his most recent published research includes a large multicenter
study [8] involving a host of well - respected orthopedic surgeons around the country who followed 230 patients in a double - blind
randomized control
study [the gold standard for medical research].
Comparing the Kangaroo care method with standard incubator care, a
randomized control
study published in the magazine «Annals of Tropical Pediatrics» found that the former is
by far superior.
Our
study illustrates that a
randomized intervention trial with good socioeconomic information can help assess interventions designed to improve population health not only
by examining the intervention effects on primary outcomes but also
by evaluating the intervention's impact on socioeconomic inequalities.
Regarding the science criticism, it's impossible to scientifically prove
by a placebo - controlled, double - blind,
randomized study (the gold standard in science) that AP works better than a more distant style of parenting.
We hypothesized that: (a) detection of HR
by auscultation or palpation will vary
by more than 15 BPM from actual HR; and (b) the inability to accurately determine HR will be associated with errors in management of the neonate during simulated resuscitation.Using a prospective,
randomized, controlled
study design, 64 subjects participated in three simulated neonatal resuscitation scenarios.
The aim of this
study was to evaluate adherence to the Neonatal Resuscitation Program algorithm
by subjects working from memory as compared to subjects using a decision support tool that provides auditory and visual prompts to guide implementation of the Neonatal Resuscitation Program algorithm during simulated neonatal resuscitation.Healthcare professionals (physicians, nurse practitioners, obstetrical / neonatal nurses) with a current NRP card were
randomized to the control or intervention group and performed three simulated neonatal resuscitations.
To be included in this critical review,
studies had to be U.S. - based
randomized trials evaluating a breastfeeding promotion intervention, reporting breastfeeding outcome data, enrolling primarily minority participants, and conducting analyses
by intention to treat.
By the 1990s, it was recognized that the method by which causality is typically shown in scientific studies — the randomized control trial — had limited application for studying the physical punishment of childre
By the 1990s, it was recognized that the method
by which causality is typically shown in scientific studies — the randomized control trial — had limited application for studying the physical punishment of childre
by which causality is typically shown in scientific
studies — the
randomized control trial — had limited application for
studying the physical punishment of children.
Group designation was given from a randomisation list, generated using a permuted
randomized block design, with permutation block sizes of 3, 6, and 9 units, prior to
study initiation
by an external statistician.
Participants were
randomized using sequentially numbered opaque sealed envelopes, generated
by the
study's biostatistician.
Most
studies attempt to circumvent this
by using
randomized experimentation, usually comparing reactions, preferences with identical fictional candidates, varying only race / ethnicity / gender.
In three
randomized trials, treatment of chronic low back pain with radiofrequency denervation, a procedure that can be performed with different techniques including the application of an electric current to the pain - conducting nerve, resulted in either no improvement or no clinically important improvement in chronic low back pain, according to a
study published
by JAMA.
«From this we do think it is beneficial, but we would need prospective or
randomized studies to determine which groups might not benefit or even be harmed
by this therapy.»
The REACT (
Randomized Evaluation of an Algorithm for Crohn's Treatment)
study, led
by Robarts Clinical Trials at Western University (London, Canada) provides valuable new insights for community gastroenterologists which should benefit patients.
Another problem is that modeling
studies, like this one, are inherently less powerful than other kinds of medical research:
randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control
studies, which compare patients who have a condition with those who do not; or cohort
studies, which determine the risk of contracting a disease
by studying a group of people with similar demographics.
«Reduce crime and gun violence and stabilize neighborhoods: A
randomized controlled
study: As much as a 29 percent reduction in gun violence in poor neighborhoods could translate into hundreds of fewer shootings every year for cities affected
by blighted spaces.»
What sets the
study apart from most previous evaluations is its
randomized, controlled design — a relatively new approach honed
by lead author Abhijit Banerjee, an economist at the Massachusetts Institute of Technology in Cambridge, and his colleagues.
The new
study is a meta - analysis of three
randomized controlled trials conducted
by the Alliance for Clinical Trials in Oncology (formerly Cancer and Leukemia Group B)(CALGB) with support from the NCI, Intergroupe Francophone du Myélome (IFM), and the Gruppo Italiano Malattie Ematologiche dell «Adulto (GIMEMA).
The determination of each efficacy level was also based on the rigor and quantity of published
studies on the drug class: to be in Level A, for example, a class of drugs must have been supported
by at least two «Class I»
studies — well - designed, double - blind,
randomized, placebo - controlled clinical trials.
A
randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma
by about five months Findings from two phase III
studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen
They were
randomized into three treatment groups and received the assigned
study drug
by injection into the eye until the DME resolved or stabilized.
The new six - year
study, «Cognitive enhancement therapy for adult autism spectrum disorder: Results of an 18 - month
randomized clinical trial,» involved 54 adults and was led
by Shaun Eack, Ph.D., M.S.W., Pitt's David E. Epperson Professor of Social Work and Psychiatry, and Nancy Minshew, M.D., Pitt professor of psychiatry and neurology.
The data safety monitoring board of the trial, as mandated
by the
study protocol, continues to monitor outcomes in patients with a Recurrence Score of 11 to 25
randomized to chemo - endocrine therapy or endocrine therapy alone.
Motivated
by their previous finding of the presence of P - glycoprotein overexpression in the nasal lining of patients with CRS with nasal polyps, the
study authors conducted a
randomized, double - blind, placebo - controlled clinical trial
studying the use of low - dose Verapamil in 18 patients with CRS with nasal polyps.
The findings of the
randomized study (S6 - 03) were presented at the 2014 San Antonio Breast Cancer Symposium, held Dec. 6 - 9,
by Dr. Kerin Adelson, assistant professor of medical oncology at Yale Cancer Center and chief quality officer at Smilow Cancer Hospital at Yale - New Haven.
An analysis of diagnostic test results from the Prospective Multicenter Imaging
Study for Evaluation of Chest Pain (PROMISE) trial — in which patients with stable chest pain were
randomized to either anatomic or functional testing as an initial diagnostic strategy — showed that the presence and extent of coronary artery disease detected
by CT angiography better predicted the risk for future cardiac events than did measures of exercise tolerance or restricted blood flow to the heart muscle.
Among recommendations with available information on level of evidence, 90.5 percent of recommendations supported
by multiple
randomized studies were retained, vs 81.0 percent of recommendations supported
by 1
randomized trial or observational data and 73.7 percent of recommendations supported
by opinion.
In a
randomized, phase 2 multi-center clinical
study, led
by Manisha Shah, MD of The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutations.
An analysis of more than 600 class I (procedure / treatment should be performed / administered) American College of Cardiology / American Heart Association guideline recommendations published or revised since 1998 finds that about 80 percent were retained at the time of the next guideline revision, and that recommendations not supported
by multiple
randomized studies were more likely to be downgraded, reversed, or omitted, according to a
study in the May 28 issue of JAMA.
A second
study, which was another joint effort
by UW and UCSF,
randomized more than 600 people across the United States assessed as moderately or mildly depressed to one of three interventions: Akili's Project: EVO; iPST, an app deployment of problem - solving therapy; or a placebo control (an app called Health Tips, which offered healthy suggestions).
The first
study enrolled older adults diagnosed with late - life depression into a treatment trial where they were
randomized to receive either a mobile, tablet - based treatment technology developed
by Akili Interactive Labs called Project: EVO or an in - person therapy technique known as problem - solving therapy (PST).
«This is a preliminary
study that will hopefully be confirmed
by other
studies, including a
randomized diet intervention
study instroke survivors,» she says.
This
study was presented at the Featured Clinical Research Session I: Two - year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation: A
Randomized Clinical Trial from The Cardiothoracic Surgical Trials Network The Moderate Ischemic Mitral Regurgitation trial was supported
by a cooperative agreement (U01 HL088942) funded
by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health Research.
In the
randomized, controlled, six - week
study the scientists measured the impact of zinc on human metabolism
by counting DNA strand breaks.
By studying this population over time in a
randomized clinical trial, the research team was able to eliminate many confounding variables.
The 10 - year Warfarin and Aspirin for Reduced Cardiac Ejection Fraction (WARCEF) trial is the largest
randomized, double - blind comparison of aspirin and warfarin (also known
by its brand name Coumadin) for heart failure, following 2,305 heart failure patients whose heart muscle pumps less oxygen - rich blood into the body, known as reduced ejection fraction, at 168
study sites in 11 countries on three continents.
A 2000
study by Hannah et al. was the largest,
randomized controlled trial to examine the type of deliver on mother and infant outcomes.
Thirty - two students were
randomized to practice with the 3 - D - printed model or the commercial model in a simulation experience developed
by the authors of the
study.
The
study, called the Minimizing Adverse Hemorrhagic Events
by Transradial Access Site and Systemic Implementation of AngioX Program (MATRIX),
randomized more than 7,200 patients undergoing angioplasty at 78 hospitals in four European countries to bivalirudin or standard coagulation therapy.
This
study has been published in the Neuroimage journal and is part of the ActiveBrains project, which is a
randomized clinical trial involving more than 100 overweight / obese children led
by Francisco B. Ortega.
Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined
by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined
by an immunohistochemistry (IHC) assay performed
by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to
study drug administration Inclusion Criteria for Crossover: • Participants must have been
randomized to Arm A of the
study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.
This was shown
by a
randomized study in 23 countries, of more than 1000 melanoma patients, of whom 50 were from the Netherlands Cancer Institute.
Various types of meditation have been shown to improve well - being among different populations such as physicians and the general public.14, 15, 16 Preliminary evidence suggests that meditation - based interventions may slow cellular aging rates
by increasing telomerase activity, but many such
studies lacked an active control group.17, 18 Recent
randomized trials in breast cancer suggest that long - term intensive meditation interventions might have positive effects on telomerase activity.
The
randomized, double - blind, placebo - controlled
study will evaluate the safety and tolerability of multiple doses of NPT088, as well as pharmacokinetics, immunogenicity and pharmacodynamic characteristics, as measured
by Aβ and tau PET imaging.
The results of the
study, «Doping in Two Elite Athletics Competitions Assessed
by Randomized - Response Surveys» have now been published in the journal Sports Medicine.
Study Selection
Randomized placebo - controlled trials of antidepressants approved
by the Food and Drug Administration in the treatment of major or minor depressive disorder were selected.
«In keeping with a similar
randomized clinical trial previously published in the Lancet and conducted
by researchers in Rome in collaboration with us here at King's College London, the STAMPEDE
study shows that even patients that after 5 years experienced relapse of diabetes after initial and complete remission of the disease continue to maintain excellent control of their blood sugar levels with minimal or no need for glucose lowering drugs.