Sentences with phrase «randomized treatment study»

A controlled randomized treatment study: the effects of a cognitive remediation program on adolescents with early onset psychosis

Not exact matches

Besides randomized controlled clinical trials, there are a number of ways researchers can study how a particular cancer treatment is playing out in the real world: there are retrospective studies, observational studies, and even prospective research done using patient registries.

For the same reason, it is not easy to prove treatment efficacy by means of controlled, randomized studies, the «gold standard» for evaluating new therapies.

In the only controlled, randomized scientific study to compare graduated extinction and «positive routines» head - to - head, there were no significant differences in treatment outcomes for kids (Adams and Rickert 1989).

Livingston V and Stringer J: The Treatment of Staphylococcus Aureus Infected Sore Nipples: A Randomized Comparative Study, J Human Lact 1999, 15 (3): 241 - 246.

Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study.

In three randomized trials, treatment of chronic low back pain with radiofrequency denervation, a procedure that can be performed with different techniques including the application of an electric current to the pain - conducting nerve, resulted in either no improvement or no clinically important improvement in chronic low back pain, according to a study published by JAMA.

However, prior to this study there has been a lack of randomized controlled trials with a long - term follow - up that compare the effectiveness of noninvasive treatments.

The REACT (Randomized Evaluation of an Algorithm for Crohn's Treatment) study, led by Robarts Clinical Trials at Western University (London, Canada) provides valuable new insights for community gastroenterologists which should benefit patients.

Since randomized clinical trials — the gold - standard in research — don't accommodate patients» preferences, Zoellner and her research team used a study design called a «doubly randomized preference trial» to investigate whether giving patients a choice affects their treatment outcomes.

Another problem is that modeling studies, like this one, are inherently less powerful than other kinds of medical research: randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control studies, which compare patients who have a condition with those who do not; or cohort studies, which determine the risk of contracting a disease by studying a group of people with similar demographics.

The study was a randomized phase II trial testing whether the addition of local treatment, in the form of consolidative radiation therapy, to the standard treatment of systemic therapy improved progression - free survival for patients with limited metastatic NSCLC.

«This is the first study to show that a systemic therapy provides significant clinical benefit in a randomized fashion to advanced uveal melanoma patients, who have very limited treatment options,» said Richard D. Carvajal, MD, a medical oncologist at Memorial Sloan - Kettering and lead author on the study.

Dr. Bachhuber and coauthors conclude: «To fully understand the effect of medical cannabis on the use of other drugs, prospective longitudinal studies randomizing patients to cannabis versus other treatments are urgently needed.»

Women with a DCIS diagnosis who participate in the study will be randomized to receive one of two treatment approaches: The current standard of care consisting of surgery and radiation therapy, or careful monitoring with mammograms and physical exams every six months.

A total of 63 currently depressed patients, diagnosed with either major depressive disorder or bipolar disorder, participated in the study and were randomized to receive a single 20 - minute treatment of real LFMS or sham LFMS, where the device was on but the electromagnetic fields were inactive.

They were randomized into three treatment groups and received the assigned study drug by injection into the eye until the DME resolved or stabilized.

After initial screening, the researchers randomized the study participants into three groups: a referral group that received a list of treatment services; a brief intervention group that received a motivational consultation and referral; and a third group given a brief intervention and treatment with buprenorphine that was continued in primary care.

Although the study began as a randomized trial that divided subjects into four treatment groups (placebo, deprenyl, α - tocopherol, and deprenyl / α - tocopherol), this was terminated early because positive effects of deprenyl were observed and all subjects then received deprenyl for approximately 18 months.

An analysis of more than 600 class I (procedure / treatment should be performed / administered) American College of Cardiology / American Heart Association guideline recommendations published or revised since 1998 finds that about 80 percent were retained at the time of the next guideline revision, and that recommendations not supported by multiple randomized studies were more likely to be downgraded, reversed, or omitted, according to a study in the May 28 issue of JAMA.

Contrary to the proclamations of many scientists, unreliable medical study results do not disappear with large, randomized controlled trials, in which subjects are randomly assigned to a treatment or placebo group.

The first study enrolled older adults diagnosed with late - life depression into a treatment trial where they were randomized to receive either a mobile, tablet - based treatment technology developed by Akili Interactive Labs called Project: EVO or an in - person therapy technique known as problem - solving therapy (PST).

This study was presented as the Late - Breaking Clinical Trial (Abstract 49403): The Surgical Treatment of Moderate Ischemic Mitral Regurgitation: A Randomized Clinical Trial From The Cardiothoracic Surgical Trials Network.

This study was presented at the Featured Clinical Research Session I: Two - year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation: A Randomized Clinical Trial from The Cardiothoracic Surgical Trials Network The Moderate Ischemic Mitral Regurgitation trial was supported by a cooperative agreement (U01 HL088942) funded by the National Heart Lung and Blood Institute, the National Institutes of Neurological Disorders and Stroke of the National Institutes of Health (NIH), Bethesda, MD, and the Canadian Institutes of Health Research.

In the randomized study, patients were assigned to receive either intravenous metoprolol or a placebo treatment at the moment of diagnosis of a myocardial infarction during ambulance transit to the catheterization laboratory.

Similarly the epilepsy studies, including a single randomized trial, found that medical cannabis reduced the frequency of seizures in participants, some with treatment - resistant seizures.

A systematic review of published studies on the use of medical cannabis in children and adolescents finds a notable lack of studies and a minimal number of the randomized, controlled trials needed to confirm the effectiveness of a treatment.

The original, randomized, open label study, which enrolled 20 outpatient men with cirrhosis and recurrent HE receiving standard - of - care (SOC) treatment, had previously reported that a single FMT enema after antibiotic pretreatment improved cognitive function at Day 20 and reduced HE episodes and hospitalizations over the following 5 months compared with SOC.1 The long - term outcomes of this study, which were presented today at The International Liver Congress ™ 2018 in Paris, France, demonstrated sustained and statistically significant reductions in the number of HE episodes and hospitalizations as well as improvements in cognitive function over 1 year in the men who received FMT compared with the control group.

Study participants (n = 146; 101 males, 45 females) were enrolled in a 16 - week randomized clinical trial comparing naltrexone with placebo treatment.

He also believes that additional research — possibly randomized, prospective studies — should be done to compare the safety and efficacy of PAE with other commonly performed BPH treatments.

In the randomized, blinded study, half of the participants received the treatment while half received a placebo.

In the double - blind, randomized crossover study, every patient had the opportunity to try every one of the three treatments: the combination, morphine alone and nortriptyline alone in each of the three six - week treatment periods.

A large - scale randomized clinical study is needed to confirm the therapeutic value of video - game treatment in clinical situations.

A Phase 3 Open - Label Randomized Study of Quizartinib (AC220) Monotherapy Versus Salvage Chemotherapy in Subjects with FLT3 - ITD Positive Acute Myeloid Leukemia (AML) Refractory To or Relapsed After First - line Treatment With or Without Hematopoietic Stem Cell Transplantation (HSCT) Consolidation

14255: STAT3 Signaling During Chemo - Radiation for Squamous Cell Carcinoma of the Head and Neck 14340: A Phase II, Randomized, Open - Label, Multi-Center, Global Study of MEDI4736 Monotherapy, Tremelimumab Monotherapy, and MEDI4736 in Combination with Tremelimumab in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) 14258: Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)

A Phase III, Open Label, Randomized Study to Assess the Efficacy and Safety of Olaparib (Lynparza) versus Enzalutamide or Abiraterone Acetate in Men with Metastatic Castration - Resistant Prostate Cancer who have Failed Prior Treatment with a New Hormonal Agent and have Homologous Recombination Repair Gene Mutations.

Of special note today: gut microbiota species expressing orthologs of human Ro60 might be involved in triggering and sustaining chronic autoimmunity in lupus; The portal vein blood microbiome in patients with liver cirrhosis; A randomized clinical study suggests dietary promotion of short chain fatty acid producing gut microbes as an effective treatment for type 2 diabetes; and the sexual dimorphism of root, flower and leaf microbiomes in the wild strawberry plant

A Phase 3, Multicenter, Randomized, Open - Label Study of Guadecitabine (SGI - 110) versus Treatment Choice in Adults with Previously Treated Acute Myeloid Leukemia

Study Selection Randomized placebo - controlled trials of antidepressants approved by the Food and Drug Administration in the treatment of major or minor depressive disorder were selected.

Data were obtained from 17 randomized studies of rTMS for AVH; 5 studies fulfilled the criteria for the meta - analysis on the effect of rTMS 1 month after the end of treatment.

In a randomized, double - blind, sham - controlled study, Benninger and colleagues (2011) examined the safety and effectiveness of intermittent theta - burst stimulation (iTBS) in the treatment of motor symptoms in Parkinson disease (PD); iTBS of the motor and DLPFC was investigated in 8 sessions over 2 weeks.

[35] The first randomized, controlled study of DBS for the treatment of TRD targeting the ventral capsule / ventral striatum area did not demonstrate a significant difference in response rates between the active and sham groups at the end of a 16 - week study.

Methods: In a multicenter, randomized, patient - and rater - blind, controlled, parallel - group, phase II study, 42 AD patients were assigned (1: 1) to PE treatment or control (sham) groups.

The U.S. drug maker released a statement on Monday saying that its Keynote - 010 study, a randomized Phase two - third trial, showed that patients who were taking two different doses of Keytruda (FDA - approved two mg / kg dose and treatment dose of 10 mg / kg given every three weeks) had longer survival compared to those who took docetaxel, the drug widely used for non-small cell lung cancer (NSCLC).

The drug, a monoclonal antibody called ipilimumab, is the first treatment of any kind ever shown in a large, randomized phase III clinical study (study MDX010 - 20) to improve overall survival in patients with metastatic melanoma who no longer respond to standard therapy.

The expert review panel recommended one practice guideline based on a 2005 randomized trial that provided data to support a memory retraining protocol.12, 13 The trial enrolled 29 subjects with MS - related learning deficits and randomized them to either the control group (n = 14) or the experimental group (n = 15).13 Both groups participated in 8 «treatment» sessions, which consisted of nontraining memory tasks for the control group and the Story Memory Technique (SMT), which taught the skills of visualization and context to improve learning, for the experimental group.13 In subjects with moderately severe impairment, 88 % in the experimental group showed significant improvement in learning abilities compared with 38 % in the control group (P <.01).13 Subjects with mild impairment showed little improvement.13 On this basis, the technique used in this study was recommended by the review panel as a practice guideline for the rehabilitation of learning and memory in persons with MS. 12

According to the researchers, there have been proposals that vitamin C dosages should be more than 15 g / day for the best treatment of colds, but the highest dosages that have so far been looked at in randomized studies have been much lower.

The 2012 Treatment Options for Type 2 Diabetes in Adolescents and Youths (TODAY) randomized study reduced caloric intake to a miniscule 1200 - 1500 calories per day of a low - fat diet.

A systematic review of 17, randomized controlled trials found 11 studies that linked regular yoga practice to significantly greater reductions in systolic BP compared to pharmacotherapy, breath awareness, health education, no treatment, or usual care.

One randomized double blind comparison study assessed the effectiveness of two different ointments containing witch hazel in the treatment of 22 patients with moderate or severe eczema.