Sentences with phrase «rapid cell aging»
An alternative approach is to cause rapid cell aging and induce premature senescence, which we believe could become a new frontier in cancer drug development.»
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Malfunctioning mitochondria can cause problems in every cell in the body, contributing massive stress to our internal environment, increasing inflammation, rapid breakdown of tissues, and eventually degeneration of the human body (AKA rapid aging).
Selective deletion of cochlear hair cells causes rapid age - dependent changes in spiral ganglion and cochlear nucleus neurons.
(6) Following this initial test of abrogating the early, age - related rise in p16Ink4a - expressing cell burden, the investigators probed the effects of leaving BubR1H / H; INK - ATTAC to undergo 5 months of rapid «premature aging» (and thus, to the attendant accumulation of high levels of p16Ink4a - positive cells and onset of «early - aging» phenotypes), and only then inducing ablation of senescent cells with the INK - ATTAC drug - activated system (see Figure 2 (g) below).
As the investigators note, the rapid age - related arterial stiffening and cardiac arrhythmias that appear to be at cause for the majority of deaths in BubR1H / H mice were not attenuated by ablating p16Ink4a - expressing senescent cells — but these tissues had little burden of such cells, so this finding reinforces the conclusion that the multiple aging phenotypes arrested in these mice when senescent cells were ablated is attributable specifically to the removal of their baleful influence on local tissues.
The researchers followed up to identify markers of aging in these cells, using several mouse models — one with impaired glucose tolerance (a contributor to type 2 diabetes progression) and another that shows markers of rapid aging.
Thankfully, there's something you can do to prevent the rapid loss of this vital cell function — helping you age better and stay active.
Treating with a chemical exfoliation two to three times a week promotes more rapid cell turnover resulting in brighter and clearer skin and slows the aging process.
When dogs, cats, and people are younger, they have an abundance of activated stem cells that facilitate healing at a more rapid rate than the aging patient.