Macrophage αMβ2 integrins bind to the GPIbα subunit of the clustered complex, resulting in
rapid clearance of transfused, cooled platelets.
Originally considered as innocuous and
with rapid clearance on administration, in the last ten years concerns on the safety of gadolinium - based contrast agents (Gd - CAs) have been raised.
Perhaps blocking
the rapid clearance of TRL remnants through LDLR and LRP1 has an adaptive role in shunting fatty acids liberated from plasma TGs to the heart and skeletal muscle when food is less plentiful.
The slower absorbance and
rapid clearance may improve glycemic control.